STRINGSTRING
GABRB3 GABRB3 GABRB2 GABRB2 CACNG4 CACNG4 NPY NPY CACNA1A CACNA1A RGS2 RGS2 Tbc1d24 Tbc1d24 BRD2 BRD2 ALDH7A1 ALDH7A1 ADAM22 ADAM22 ADAM23 ADAM23 IGFBP5 IGFBP5 TGFB3 TGFB3 EGR3 EGR3 KCNJ16 KCNJ16 BDNF BDNF TEF TEF PNPO PNPO PDXK PDXK EEF1D EEF1D GRIK1 GRIK1 GRIN2C GRIN2C WWOX WWOX SCN1A SCN1A TSC2 TSC2 FMR1 FMR1 ACSM5 ACSM5 GABRA5 GABRA5 ZEB2 ZEB2 HMGCR HMGCR GRIN2A GRIN2A GRIN2B GRIN2B GABRA1 GABRA1 CDKL5 CDKL5 TGFB2 TGFB2 GSTM1 GSTM1 KCNQ3 KCNQ3 CACNA2D3 CACNA2D3 CHRNA4 CHRNA4 MSH3 MSH3 MTOR MTOR MAG MAG ATP10A ATP10A PLPBP PLPBP TTR TTR SYN1 SYN1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
Tbc1d24Uncharacterized protein. (561 aa)
BRD2Bromodomain containing 2. (804 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
ADAM22ADAM metallopeptidase domain 22. (928 aa)
ADAM23ADAM metallopeptidase domain 23. (775 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EGR3Early growth response 3. (388 aa)
KCNJ16Inwardly-rectifying potassium channel Kir5.1. (419 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
TEFTEF transcription factor, PAR bZIP family member. (275 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (260 aa)
PDXKPyridoxal kinase. (312 aa)
EEF1DEukaryotic translation elongation factor 1 delta; Belongs to the EF-1-beta/EF-1-delta family. (649 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
TSC2TSC complex subunit 2. (1745 aa)
FMR1Fragile X mental retardation 1. (612 aa)
ACSM5Acyl-CoA synthetase medium chain family member 5. (579 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1253 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
GABRA1Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
CDKL5Cyclin dependent kinase like 5. (947 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
GSTM1Glutathione S-transferase B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (222 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (860 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (991 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
MSH3MutS homolog 3. (1047 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
MAGMyelin associated glycoprotein. (592 aa)
ATP10APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1483 aa)
PLPBPPyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (275 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (131 aa)
SYN1Synapsin I. (690 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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