(18 nodes) (2023) CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. network (Cavia porcellus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	CD63	Tetraspanin. (238 aa)
	CD44	CD44 molecule (Indian blood group). (660 aa)
	Pdcd6ip	BRO1 domain-containing protein. (872 aa)
	EGFR	Receptor protein-tyrosine kinase. (1214 aa)
	Gapdh	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa)
	CDC42	Cell division cycle 42. (191 aa)
	RHOA	Ras homolog family member A. (193 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	TSG101	Tumor susceptibility 101. (391 aa)
	ARF1	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	Cav2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (125 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2079 aa)
	LGALS3	Galectin. (244 aa)
	LAMP1	Lysosomal associated membrane protein 1. (410 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF1	CAV1	ENSCPOP00000028546	ENSCPOP00000027566	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.409
ARF1	CD44	ENSCPOP00000028546	ENSCPOP00000007016	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	CD44 molecule (Indian blood group).	0.401
ARF1	CDC42	ENSCPOP00000028546	ENSCPOP00000031577	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Cell division cycle 42.	0.463
CAV1	ARF1	ENSCPOP00000027566	ENSCPOP00000028546	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	0.409
CAV1	CAV3	ENSCPOP00000027566	ENSCPOP00000030684	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.940
CAV1	CD63	ENSCPOP00000027566	ENSCPOP00000008209	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tetraspanin.	0.484
CAV1	CDC42	ENSCPOP00000027566	ENSCPOP00000031577	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cell division cycle 42.	0.714
CAV1	Cav2	ENSCPOP00000027566	ENSCPOP00000026859	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.998
CAV1	EGFR	ENSCPOP00000027566	ENSCPOP00000000034	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.941
CAV1	LAMP1	ENSCPOP00000027566	ENSCPOP00000015749	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Lysosomal associated membrane protein 1.	0.624
CAV1	RHOA	ENSCPOP00000027566	ENSCPOP00000031238	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ras homolog family member A.	0.765
CAV1	ROCK1	ENSCPOP00000027566	ENSCPOP00000009405	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.478
CAV1	ROCK2	ENSCPOP00000027566	ENSCPOP00000011391	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.465
CAV1	WNT3A	ENSCPOP00000027566	ENSCPOP00000024420	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.599
CAV3	CAV1	ENSCPOP00000030684	ENSCPOP00000027566	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.940
CAV3	CDC42	ENSCPOP00000030684	ENSCPOP00000031577	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cell division cycle 42.	0.533
CAV3	Cav2	ENSCPOP00000030684	ENSCPOP00000026859	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV3	EGFR	ENSCPOP00000030684	ENSCPOP00000000034	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein-tyrosine kinase.	0.895
CAV3	RHOA	ENSCPOP00000030684	ENSCPOP00000031238	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ras homolog family member A.	0.634
CAV3	ROCK1	ENSCPOP00000030684	ENSCPOP00000009405	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.429