STRINGSTRING
TNF TNF LOC100723623 LOC100723623 ANXA7 ANXA7 FCGR2 FCGR2 Anxa2 Anxa2 IL2 IL2 ANXA13 ANXA13 IFNG IFNG IL21 IL21 ANXA3 ANXA3 ANXA1 ANXA1 CTLA4 CTLA4 LAMP1 LAMP1 ANXA11 ANXA11 ARG1 ARG1 ANXA6 ANXA6 ANXA5 ANXA5 CD8A CD8A CXCL10 CXCL10 ITGAM ITGAM ANXA4 ANXA4 KLRG1 KLRG1 ANXA9 ANXA9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
FCGR2Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
Anxa2Annexin. (339 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
ANXA13Annexin. (315 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
ANXA3Annexin. (323 aa)
ANXA1Annexin. (346 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
LAMP1Lysosomal associated membrane protein 1. (410 aa)
ANXA11Annexin. (499 aa)
ARG1Arginase. (322 aa)
ANXA6Annexin. (753 aa)
ANXA5Annexin. (318 aa)
CD8ACD8 alpha. (237 aa)
CXCL10C-X-C motif chemokine ligand 10. (97 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
ANXA4Annexin. (321 aa)
KLRG1Killer cell lectin like receptor G1. (191 aa)
ANXA9Annexin. (345 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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