STRINGSTRING
TLR4 TLR4 EGFR EGFR IL1B IL1B TNF TNF VTN VTN COL1A1 COL1A1 PADI4 PADI4 MMP9 MMP9 TGFB2 TGFB2 CD44 CD44 ACAN ACAN HPX HPX SST SST IL21 IL21 TLR2 TLR2 SRC SRC RDX RDX MMP3 MMP3 SELL SELL TGFB3 TGFB3 CD86 CD86 PLOD2 PLOD2 SMAD3 SMAD3 MSN MSN EZR EZR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
VTNSMB domain-containing protein. (482 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
PADI4Peptidyl arginine deiminase 4. (670 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
CD44CD44 molecule (Indian blood group). (660 aa)
ACANAggrecan. (2119 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (435 aa)
SSTSomatostatin. (116 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
SRCTyrosine-protein kinase. (542 aa)
RDXRadixin. (604 aa)
MMP3Matrix metallopeptidase 3. (479 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (365 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CD86CD86 molecule. (320 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (691 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MSNMoesin. (577 aa)
EZREzrin. (586 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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