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CARTPT CARTPT TPH1 TPH1 MAOB MAOB MAOA MAOA ACAD10 ACAD10 ACAT2 ACAT2 ALDH16A1 ALDH16A1 ACMSD ACMSD IL4I1 IL4I1 Dld Dld DDC DDC TPH2 TPH2 HADHA HADHA ALDH8A1 ALDH8A1 LOC100732696 LOC100732696 GTPBP1 GTPBP1 KATNAL2 KATNAL2 DHTKD1 DHTKD1 TDO2 TDO2 SPAST SPAST Dlst Dlst KYAT3 KYAT3 KYNU KYNU ECHS1 ECHS1 CAT CAT KMO KMO ACAT1 ACAT1 ALDH9A1 ALDH9A1 CYP1A1 CYP1A1 LOC100735244 LOC100735244 AFMID AFMID HADH HADH Aox4 Aox4 FIGN FIGN FIGNL2 FIGNL2 H0W3I3_CAVPO H0W3I3_CAVPO CYP1A2 CYP1A2 Kyat1 Kyat1 AOC1 AOC1 HAAO HAAO GCDH GCDH FIGNL1 FIGNL1 AOX2 AOX2 Aox1 Aox1 ALDH3A2 ALDH3A2 TTLL12 TTLL12 ALDH7A1 ALDH7A1 IDO1 IDO1 EHHADH EHHADH ENSCPOP00000026353 ENSCPOP00000026353 WDTC1 WDTC1 Aldh2 Aldh2 AADAT AADAT CYP1B1 CYP1B1 AANAT AANAT IDO2 IDO2 ENSCPOP00000032995 ENSCPOP00000032995
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CARTPTCART prepropeptide. (129 aa)
TPH1Tryptophan hydroxylase 1. (420 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (520 aa)
MAOAAmine oxidase. (461 aa)
ACAD10Acyl-CoA dehydrogenase family member 10. (1059 aa)
ACAT2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ALDH16A1Aldehyde dehydrogenase family 16 member A1. (804 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
IL4I1Amine oxidase. (546 aa)
DldDihydrolipoyl dehydrogenase. (509 aa)
DDCAromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (480 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (762 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
LOC100732696Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (718 aa)
GTPBP1GTP binding protein 1. (666 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (540 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (920 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (405 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
DlstLipoyl-binding domain-containing protein. (440 aa)
KYAT3Kynurenine aminotransferase 3. (451 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (466 aa)
ECHS1Enoyl-CoA hydratase, short chain 1; Belongs to the enoyl-CoA hydratase/isomerase family. (290 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (527 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (487 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
ALDH9A1Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family. (518 aa)
CYP1A1Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (516 aa)
LOC100735244Amine oxidase. (567 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (306 aa)
HADHHydroxyacyl-CoA dehydrogenase. (313 aa)
Aox4Aldehyde oxidase 4; Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles (By similarity); Belongs to the xanthine dehydrogenase family. (1341 aa)
FIGNFidgetin, microtubule severing factor; Belongs to the AAA ATPase family. (762 aa)
FIGNL2Fidgetin like 2. (636 aa)
H0W3I3_CAVPOUncharacterized protein. (232 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (515 aa)
Kyat1Aminotran_1_2 domain-containing protein. (424 aa)
AOC1Amine oxidase. (753 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
GCDHGlutaryl-CoA dehydrogenase. (414 aa)
FIGNL1Fidgetin like 1; Belongs to the AAA ATPase family. (676 aa)
AOX2Aldehyde oxidase 2; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. (1334 aa)
Aox1Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] (1329 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
TTLL12Tubulin tyrosine ligase like 12. (639 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (405 aa)
EHHADHEnoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (726 aa)
ENSCPOP00000026353Dihydrolipoyl dehydrogenase. (501 aa)
WDTC1WD and tetratricopeptide repeats 1. (678 aa)
Aldh2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (521 aa)
AADATAminoadipate aminotransferase. (425 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa)
AANATAralkylamine N-acetyltransferase. (205 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (359 aa)
ENSCPOP00000032995Lipoyl-binding domain-containing protein. (440 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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