STRINGSTRING
EGFR EGFR Notch4 Notch4 NCOR1 NCOR1 PIK3CB PIK3CB PTK2 PTK2 RAF1 RAF1 SOS1 SOS1 ADCY1 ADCY1 PPP1R14B PPP1R14B MAP2K1 MAP2K1 IGF1R IGF1R PTRHD1 PTRHD1 ADCY3 ADCY3 Bad Bad ERBB2 ERBB2 ABCB11 ABCB11 CEP152 CEP152 Shc4 Shc4 PIK3CA PIK3CA ADCY8 ADCY8 MMP9 MMP9 PIK3R1 PIK3R1 NCOA3 NCOA3 CCDC170 CCDC170 ESR1 ESR1 JAG2 JAG2 RB1 RB1 E2F2 E2F2 H0VE70_CAVPO H0VE70_CAVPO HBEGF HBEGF NRAS NRAS KRAS KRAS ADCY2 ADCY2 DLL4 DLL4 MTOR MTOR PIK3CD PIK3CD NOTCH1 NOTCH1 MAPK1 MAPK1 ARAF ARAF DLL3 DLL3 ADCY5 ADCY5 ADCY4 ADCY4 MAPK13 MAPK13 RPS6KB1 RPS6KB1 MAPK12 MAPK12 AKT3 AKT3 NOTCH2 NOTCH2 MAP2K2 MAP2K2 NOTCH3 NOTCH3 Bik Bik H0W027_CAVPO H0W027_CAVPO CDKN2A CDKN2A BCL2 BCL2 DLL1 DLL1 LOC100723025 LOC100723025 ESR2 ESR2 SHC3 SHC3 SP1 SP1 SHC1 SHC1 MMP2 MMP2 JUN JUN H0WDS6_CAVPO H0WDS6_CAVPO MDM2 MDM2 CDK4 CDK4 LOC100732158 LOC100732158 FOS FOS SOS2 SOS2 MAPK14 MAPK14 GPER1 GPER1 CARM1 CARM1 RPS6KB2 RPS6KB2 MAPK11 MAPK11 MAPK3 MAPK3 MAPK8 MAPK8 MAPK9 MAPK9 CDKN1A CDKN1A AKT1 AKT1 E2F1 E2F1 PRKACB PRKACB CCND1 CCND1 CDKN2C CDKN2C ADCY9 ADCY9 E2F3 E2F3 ADCY6 ADCY6 ADCY7 ADCY7 TP53 TP53 LOC100734206 LOC100734206 MED1 MED1 LOC100732436 LOC100732436 AKT2 AKT2 GRB2 GRB2 BRAF BRAF BAX BAX CSDE1 CSDE1 IGF1 IGF1 JAG1 JAG1 CDKN1B CDKN1B HRAS HRAS Prkaca Prkaca MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFRReceptor protein-tyrosine kinase. (1214 aa)
Notch4Uncharacterized protein. (1988 aa)
NCOR1Nuclear receptor corepressor 1. (2389 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
ADCY1Adenylate cyclase 1. (944 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (108 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
BadUncharacterized protein. (166 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
ABCB11Uncharacterized protein. (1320 aa)
CEP152Centrosomal protein 152. (1666 aa)
Shc4Uncharacterized protein. (372 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
CCDC170Coiled-coil domain containing 170. (688 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1095 aa)
RB1RB transcriptional corepressor 1. (840 aa)
E2F2E2F transcription factor 2. (431 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
NOTCH1Notch receptor 1. (2472 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (608 aa)
DLL3Delta like canonical Notch ligand 3. (708 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
NOTCH2Notch receptor 2. (2455 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
NOTCH3Notch receptor 3. (2141 aa)
BikUncharacterized protein. (158 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (134 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
LOC100723025Uncharacterized protein. (431 aa)
ESR2Estrogen receptor 2. (568 aa)
SHC3SHC adaptor protein 3. (418 aa)
SP1Sp1 transcription factor. (786 aa)
SHC1SHC adaptor protein 1. (583 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WDS6_CAVPOUncharacterized protein. (533 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
LOC100732158Uncharacterized protein. (246 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (641 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (389 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
E2F3E2F transcription factor 3. (457 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
LOC100734206Uncharacterized protein. (461 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
LOC100732436Uncharacterized protein. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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