STRINGSTRING
RAD17 RAD17 YJU2 YJU2 SASS6 SASS6 RPA1 RPA1 Lig1 Lig1 RFC1 RFC1 C16orf70 C16orf70 POLE2 POLE2 MCM6 MCM6 GDAP2 GDAP2 FEN1 FEN1 RNASEH2A RNASEH2A MACROD2 MACROD2 PRKRIP1 PRKRIP1 TOR4A TOR4A RPA3 RPA3 Tm4sf19 Tm4sf19 TOR2A TOR2A STN1 STN1 GEN1 GEN1 CHRAC1 CHRAC1 DNA2 DNA2 POLE3 POLE3 Pold4 Pold4 POLE4 POLE4 MCM7 MCM7 POLD1 POLD1 PARP14 PARP14 CPNE7 CPNE7 CABP5 CABP5 TOR1B TOR1B CPNE5 CPNE5 CPNE1 CPNE1 CPNE2 CPNE2 EXOC8 EXOC8 MCM5 MCM5 POLD2 POLD2 Rnaseh1 Rnaseh1 RFC5 RFC5 Parp9 Parp9 Prim1 Prim1 H0VSI3_CAVPO H0VSI3_CAVPO CPNE3 CPNE3 RNASEH2C RNASEH2C POLE POLE TOR3A TOR3A WRNIP1 WRNIP1 RFC2 RFC2 ATAD5 ATAD5 MACROD1 MACROD1 RFC4 RFC4 MCM9 MCM9 FAM162A FAM162A FAM162B FAM162B Pold3 Pold3 MCMDC2 MCMDC2 Ppil3 Ppil3 PRIM2 PRIM2 RNASEH2B RNASEH2B CPNE8 CPNE8 RPA2 RPA2 CPNE9 CPNE9 PCNA PCNA RFC3 RFC3 MEIOB MEIOB MCM3 MCM3 CPNE4 CPNE4 CPNE6 CPNE6 SSBP1 SSBP1 POLA1 POLA1 Pola2 Pola2 MCM2 MCM2 MAML1 MAML1 TOR1A TOR1A MCM4 MCM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD17RAD17 checkpoint clamp loader component. (696 aa)
YJU2YJU2 splicing factor homolog. (305 aa)
SASS6SAS-6 centriolar assembly protein. (590 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
Lig1DNA ligase. (909 aa)
RFC1Replication factor C subunit 1. (1153 aa)
C16orf70Chromosome 16 open reading frame 70. (422 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
GDAP2Ganglioside induced differentiation associated protein 2. (497 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa)
MACROD2Mono-ADP ribosylhydrolase 2. (424 aa)
PRKRIP1PRKR interacting protein 1. (186 aa)
TOR4ATorsin family 4 member A. (413 aa)
RPA3Replication protein A3. (121 aa)
Tm4sf19Uncharacterized protein. (232 aa)
TOR2ATorsin. (321 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (916 aa)
CHRAC1Chromatin accessibility complex subunit 1. (129 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
Pold4Uncharacterized protein. (107 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (116 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
POLD1DNA polymerase. (1134 aa)
PARP14Poly [ADP-ribose] polymerase. (1659 aa)
CPNE7Copine 7. (552 aa)
CABP5Calcium binding protein 5. (173 aa)
TOR1BTorsin. (338 aa)
CPNE5Copine 5. (593 aa)
CPNE1Copine 1. (537 aa)
CPNE2Copine 2. (548 aa)
EXOC8Exocyst complex component 8. (716 aa)
MCM5DNA helicase; Belongs to the MCM family. (731 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
Rnaseh1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (294 aa)
RFC5Replication factor C subunit 5. (340 aa)
Parp9Uncharacterized protein. (703 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
CPNE3Copine 3. (523 aa)
RNASEH2CRibonuclease H2 subunit C. (165 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
TOR3ATorsin family 3 member A. (399 aa)
WRNIP1WRN helicase interacting protein 1. (568 aa)
RFC2Replication factor C subunit 2. (352 aa)
ATAD5ATPase family AAA domain containing 5. (1831 aa)
MACROD1Mono-ADP ribosylhydrolase 1. (311 aa)
RFC4Replication factor C subunit 4. (363 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
FAM162BFamily with sequence similarity 162 member B. (142 aa)
Pold3Uncharacterized protein. (466 aa)
MCMDC2Minichromosome maintenance domain containing 2. (657 aa)
Ppil3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
PRIM2DNA primase subunit 2. (432 aa)
RNASEH2BRibonuclease H2 subunit B. (310 aa)
CPNE8Copine 8. (516 aa)
RPA2Replication protein A2. (270 aa)
CPNE9Copine family member 9. (553 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RFC3Replication factor C subunit 3. (220 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
CPNE4Copine 4. (557 aa)
CPNE6Copine 6. (557 aa)
SSBP1Single stranded DNA binding protein 1. (137 aa)
POLA1DNA polymerase. (1467 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
MAML1Mastermind like transcriptional coactivator 1. (794 aa)
TOR1ATorsin. (332 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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