63 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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	OGG1	8-oxoguanine DNA glycosylase. (303 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
	NEIL1	Nei like DNA glycosylase 1. (401 aa)
	CACHD1	Cache domain containing 1. (1272 aa)
	Mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
	LIG3	DNA ligase. (1012 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
	PARP3	Poly [ADP-ribose] polymerase. (533 aa)
	Glipr1l2	SCP domain-containing protein. (116 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1702 aa)
	H0VSI3_CAVPO	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
	R3HDML	R3H domain containing like; Belongs to the CRISP family. (275 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	H0VVJ6_CAVPO	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (1247 aa)
	PARP2	Poly [ADP-ribose] polymerase. (536 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	MBD3	Methyl-CpG binding domain protein 3. (290 aa)
	H0WAS6_CAVPO	Uncharacterized protein. (214 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1204 aa)
	CABP5	Calcium binding protein 5. (173 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa)
	POLD1	DNA polymerase. (1134 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (116 aa)
	MGMT	O-6-methylguanine-DNA methyltransferase. (208 aa)
	Pold4	Uncharacterized protein. (107 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	CHRAC1	Chromatin accessibility complex subunit 1. (129 aa)
	ENSCPOP00000023083	B-block_TFIIIC domain-containing protein. (283 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (916 aa)
	Hmgb1	annotation not available (215 aa)
	ENSCPOP00000024428	PARP-type domain-containing protein. (104 aa)
	UNG-2	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
	HMGB3	High mobility group box 3. (202 aa)
	ENSCPOP00000025508	SCP domain-containing protein; Belongs to the CRISP family. (227 aa)
	PRKRIP1	PRKR interacting protein 1. (186 aa)
	MPG	N-methylpurine DNA glycosylase. (300 aa)
	XRCC1	X-ray repair cross complementing 1. (629 aa)
	ENSCPOP00000032088	Uncharacterized protein. (191 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (732 aa)
	VWA5A	Von Willebrand factor A domain containing 5A. (798 aa)
	H0V4D6_CAVPO	Uncharacterized protein. (176 aa)
	ADAT2	Adenosine deaminase tRNA specific 2. (209 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
	METTL4	Methyltransferase like 4; Belongs to the MT-A70-like family. (470 aa)
	NEIL2	Nei like DNA glycosylase 2. (336 aa)
	MBD2	Methyl-CpG binding domain protein 2. (333 aa)
	Pold3	Uncharacterized protein. (466 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
	TDG	Thymine DNA glycosylase. (413 aa)
	Ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	HMGB4	High mobility group box 4. (184 aa)
	CRISPLD1	Cysteine rich secretory protein LCCL domain containing 1. (500 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1203 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa)
	NEIL3	Nei like DNA glycosylase 3. (607 aa)
	HMGB2	High mobility group box 2. (211 aa)
	Lig1	DNA ligase. (909 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAT2	APEX1	ENSCPOP00000004831	ENSCPOP00000032125	Adenosine deaminase tRNA specific 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.625
ADAT2	APEX2	ENSCPOP00000004831	ENSCPOP00000006545	Adenosine deaminase tRNA specific 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.625
ADAT2	OGG1	ENSCPOP00000004831	ENSCPOP00000007880	Adenosine deaminase tRNA specific 2.	8-oxoguanine DNA glycosylase.	0.455
ADAT2	TDG	ENSCPOP00000004831	ENSCPOP00000000127	Adenosine deaminase tRNA specific 2.	Thymine DNA glycosylase.	0.468
ADAT2	UNG	ENSCPOP00000004831	ENSCPOP00000021244	Adenosine deaminase tRNA specific 2.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.462
ADAT2	UNG-2	ENSCPOP00000004831	ENSCPOP00000024702	Adenosine deaminase tRNA specific 2.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.462
APEX1	ADAT2	ENSCPOP00000032125	ENSCPOP00000004831	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Adenosine deaminase tRNA specific 2.	0.625
APEX1	APEX2	ENSCPOP00000032125	ENSCPOP00000006545	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.927
APEX1	ENSCPOP00000024428	ENSCPOP00000032125	ENSCPOP00000024428	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	PARP-type domain-containing protein.	0.755
APEX1	FEN1	ENSCPOP00000032125	ENSCPOP00000032223	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.994
APEX1	GEN1	ENSCPOP00000032125	ENSCPOP00000023506	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	GEN1 Holliday junction 5' flap endonuclease.	0.719
APEX1	H0V4D6_CAVPO	ENSCPOP00000032125	ENSCPOP00000004474	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.646
APEX1	H0VSI3_CAVPO	ENSCPOP00000032125	ENSCPOP00000013590	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.846
APEX1	LIG3	ENSCPOP00000032125	ENSCPOP00000011732	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.840
APEX1	Lig1	ENSCPOP00000032125	ENSCPOP00000003796	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.846
APEX1	MBD2	ENSCPOP00000032125	ENSCPOP00000006158	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG binding domain protein 2.	0.418
APEX1	MBD3	ENSCPOP00000032125	ENSCPOP00000018617	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG binding domain protein 3.	0.418
APEX1	MECP2	ENSCPOP00000032125	ENSCPOP00000011316	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.413
APEX1	MGMT	ENSCPOP00000032125	ENSCPOP00000022358	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	O-6-methylguanine-DNA methyltransferase.	0.402
APEX1	MPG	ENSCPOP00000032125	ENSCPOP00000028846	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	N-methylpurine DNA glycosylase.	0.780