40 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	Lig1	DNA ligase. (909 aa)
	MLH1	MutL homolog 1. (758 aa)
	SSBP1	Single stranded DNA binding protein 1. (137 aa)
	MEIOB	Meiosis specific with OB-fold. (471 aa)
	REXO4	REX4 homolog, 3'-5' exonuclease. (437 aa)
	MSH4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (884 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa)
	Msh5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (828 aa)
	RAD17	RAD17 checkpoint clamp loader component. (696 aa)
	YJU2	YJU2 splicing factor homolog. (305 aa)
	SASS6	SAS-6 centriolar assembly protein. (590 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (890 aa)
	EXO1	Exonuclease 1. (839 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	ISG20	Interferon stimulated exonuclease gene 20. (190 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (930 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
	RPA3	Replication protein A3. (121 aa)
	PRKRIP1	PRKR interacting protein 1. (186 aa)
	ISG20L2	Interferon stimulated exonuclease gene 20 like 2. (361 aa)
	Pold4	Uncharacterized protein. (107 aa)
	POLD1	DNA polymerase. (1134 aa)
	CABP5	Calcium binding protein 5. (173 aa)
	MLH3	MutL homolog 3. (1455 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	AEN	Apoptosis enhancing nuclease. (320 aa)
	H0VSI3_CAVPO	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	ATAD5	ATPase family AAA domain containing 5. (1831 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	MSH3	MutS homolog 3. (1047 aa)
	FBH1	F-box DNA helicase 1. (1012 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RPA2	Replication protein A2. (270 aa)
	RFC3	Replication factor C subunit 3. (220 aa)
	Ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	Pold3	Uncharacterized protein. (466 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	FBH1	ENSCPOP00000015351	ENSCPOP00000009500	Apoptosis enhancing nuclease.	F-box DNA helicase 1.	0.692
AEN	PCNA	ENSCPOP00000015351	ENSCPOP00000008297	Apoptosis enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.873
AEN	RAD17	ENSCPOP00000015351	ENSCPOP00000000749	Apoptosis enhancing nuclease.	RAD17 checkpoint clamp loader component.	0.502
AEN	RFC2	ENSCPOP00000015351	ENSCPOP00000011113	Apoptosis enhancing nuclease.	Replication factor C subunit 2.	0.502
AEN	RFC3	ENSCPOP00000015351	ENSCPOP00000007845	Apoptosis enhancing nuclease.	Replication factor C subunit 3.	0.508
AEN	RFC4	ENSCPOP00000015351	ENSCPOP00000010061	Apoptosis enhancing nuclease.	Replication factor C subunit 4.	0.502
AEN	RFC5	ENSCPOP00000015351	ENSCPOP00000016590	Apoptosis enhancing nuclease.	Replication factor C subunit 5.	0.502
AEN	SSBP1	ENSCPOP00000015351	ENSCPOP00000003031	Apoptosis enhancing nuclease.	Single stranded DNA binding protein 1.	0.469
ATAD5	EXO1	ENSCPOP00000010706	ENSCPOP00000000318	ATPase family AAA domain containing 5.	Exonuclease 1.	0.967
ATAD5	FBH1	ENSCPOP00000010706	ENSCPOP00000009500	ATPase family AAA domain containing 5.	F-box DNA helicase 1.	0.741
ATAD5	H0VSI3_CAVPO	ENSCPOP00000010706	ENSCPOP00000013590	ATPase family AAA domain containing 5.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.819
ATAD5	Lig1	ENSCPOP00000010706	ENSCPOP00000003796	ATPase family AAA domain containing 5.	DNA ligase.	0.819
ATAD5	MEIOB	ENSCPOP00000010706	ENSCPOP00000001396	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.863
ATAD5	MLH1	ENSCPOP00000010706	ENSCPOP00000003547	ATPase family AAA domain containing 5.	MutL homolog 1.	0.432
ATAD5	MSH2	ENSCPOP00000010706	ENSCPOP00000012880	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.518
ATAD5	MSH3	ENSCPOP00000010706	ENSCPOP00000010001	ATPase family AAA domain containing 5.	MutS homolog 3.	0.454
ATAD5	MSH6	ENSCPOP00000010706	ENSCPOP00000000836	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.570
ATAD5	PCNA	ENSCPOP00000010706	ENSCPOP00000008297	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.990
ATAD5	POLD1	ENSCPOP00000010706	ENSCPOP00000021510	ATPase family AAA domain containing 5.	DNA polymerase.	0.862
ATAD5	POLD2	ENSCPOP00000010706	ENSCPOP00000018386	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.728