STRINGSTRING
ENSCPOP00000033122 ENSCPOP00000033122 MUS81 MUS81 ATRX ATRX SUGP1 SUGP1 RBBP8 RBBP8 RBPMS2 RBPMS2 Pold3 Pold3 Babam1 Babam1 PALB2 PALB2 RAD54L RAD54L Abraxas2 Abraxas2 BRCA2 BRCA2 SLF1 SLF1 RAD51C RAD51C SLC4A1AP SLC4A1AP N4BP2L1 N4BP2L1 SSBP1 SSBP1 Rad50 Rad50 TOP3B TOP3B BLM BLM MEIOB MEIOB ABRAXAS1 ABRAXAS1 DDX52 DDX52 SYCP3 SYCP3 RAD52 RAD52 YJU2 YJU2 SASS6 SASS6 RPA1 RPA1 Ppil3 Ppil3 PITHD1 PITHD1 RPA2 RPA2 HELQ HELQ UIMC1 UIMC1 RAD51B RAD51B ATM ATM SAP130 SAP130 BARD1 BARD1 Rad54b Rad54b BRIP1 BRIP1 MPHOSPH9 MPHOSPH9 XRCC2 XRCC2 Brca1 Brca1 HELB HELB NBN NBN RAD51 RAD51 DMC1 DMC1 TOP3A TOP3A MCPH1 MCPH1 RECQL4 RECQL4 N4BP2 N4BP2 XRCC3 XRCC3 PTGDR2 PTGDR2 CNP CNP POLD2 POLD2 H0WAH6_CAVPO H0WAH6_CAVPO EME1 EME1 SUGP2 SUGP2 POLD1 POLD1 RECQL5 RECQL5 Pold4 Pold4 C12orf66 C12orf66 BRCC3 BRCC3 FICD FICD STN1 STN1 Sem1 Sem1 RPA3 RPA3 BABAM2 BABAM2 TOPBP1 TOPBP1 PRKRIP1 PRKRIP1 PWWP2A PWWP2A ENSCPOP00000030454 ENSCPOP00000030454 LURAP1 LURAP1 UNC93A UNC93A RAD51D RAD51D UNC93B1 UNC93B1 MCFD2 MCFD2 MRE11 MRE11 PIF1 PIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000033122MPN domain-containing protein. (250 aa)
MUS81MUS81 structure-specific endonuclease subunit. (562 aa)
ATRXATRX chromatin remodeler. (2481 aa)
SUGP1SURP and G-patch domain containing 1. (651 aa)
RBBP8RB binding protein 8, endonuclease. (900 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (178 aa)
Pold3Uncharacterized protein. (466 aa)
Babam1Uncharacterized protein. (337 aa)
PALB2Partner and localizer of BRCA2. (1172 aa)
RAD54LRAD54 like. (748 aa)
Abraxas2MPN domain-containing protein. (422 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1061 aa)
RAD51CRAD51 paralog C. (373 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (738 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (236 aa)
SSBP1Single stranded DNA binding protein 1. (137 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
BLMBLM RecQ like helicase. (1405 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (371 aa)
DDX52DExD-box helicase 52. (594 aa)
SYCP3Synaptonemal complex protein 3. (169 aa)
RAD52RAD52 homolog, DNA repair protein. (280 aa)
YJU2YJU2 splicing factor homolog. (305 aa)
SASS6SAS-6 centriolar assembly protein. (590 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
Ppil3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
PITHD1PITH domain containing 1. (211 aa)
RPA2Replication protein A2. (270 aa)
HELQHelicase, POLQ like. (1054 aa)
UIMC1Ubiquitin interaction motif containing 1. (716 aa)
RAD51BRAD51 paralog B. (258 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
SAP130Sin3A associated protein 130. (931 aa)
BARD1BRCA1 associated RING domain 1. (662 aa)
Rad54bUncharacterized protein. (901 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (971 aa)
MPHOSPH9M-phase phosphoprotein 9. (970 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
Brca1Uncharacterized protein. (79 aa)
HELBDNA helicase B. (1063 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa)
MCPH1Uncharacterized protein. (786 aa)
RECQL4RecQ like helicase 4. (1226 aa)
N4BP2NEDD4 binding protein 2. (1675 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa)
PTGDR2Chemoattractant receptor-homologous molecule expressed on Th2 cells; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (420 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
H0WAH6_CAVPOMPN domain-containing protein. (379 aa)
EME1Essential meiotic structure-specific endonuclease 1. (578 aa)
SUGP2SURP and G-patch domain containing 2. (1082 aa)
POLD1DNA polymerase. (1134 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa)
Pold4Uncharacterized protein. (107 aa)
C12orf66Chromosome 12 open reading frame 66. (445 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
FICDFIC domain containing. (458 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
Sem1Uncharacterized protein. (70 aa)
RPA3Replication protein A3. (121 aa)
BABAM2BRISC and BRCA1 A complex member 2. (358 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1392 aa)
PRKRIP1PRKR interacting protein 1. (186 aa)
PWWP2APWWP domain containing 2A. (722 aa)
ENSCPOP00000030454Uncharacterized protein. (139 aa)
LURAP1Leucine rich adaptor protein 1. (237 aa)
UNC93AUnc-93 homolog A. (428 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (614 aa)
MCFD2Multiple coagulation factor deficiency 2. (146 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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