STRINGSTRING
SHOC2 SHOC2 PLD1 PLD1 KRAS KRAS NRAS NRAS FGF20 FGF20 H0VH94_CAVPO H0VH94_CAVPO IKBKB IKBKB PLA2G2E PLA2G2E GNG13 GNG13 KDR KDR TEK TEK H0VFH9_CAVPO H0VFH9_CAVPO TGFA TGFA PLCE1 PLCE1 EFNA5 EFNA5 ELK1 ELK1 PLA2G2D PLA2G2D GNGT1 GNGT1 FGF19 FGF19 ARF6 ARF6 FLT4 FLT4 RASA1 RASA1 FGF16 FGF16 PIK3R1 PIK3R1 RASA3 RASA3 NFKB1 NFKB1 FGF3 FGF3 H0V9U3_CAVPO H0V9U3_CAVPO FLT3 FLT3 PLA1A PLA1A PIK3CA PIK3CA FGFR1 FGFR1 Shc4 Shc4 CEP152 CEP152 PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLD2 PLD2 RASGRF2 RASGRF2 NF1 NF1 FGF18 FGF18 GRIN2B GRIN2B PDGFRB PDGFRB ABL1 ABL1 FGF23 FGF23 Bad Bad GNB1 GNB1 IGF1R IGF1R PDGFB PDGFB FGF2 FGF2 RAB5A RAB5A Ralgds Ralgds ZAP70 ZAP70 PLA2G12A PLA2G12A VEGFD VEGFD EXOC2 EXOC2 PRKCB PRKCB NTRK1 NTRK1 MAP2K1 MAP2K1 RAPGEF5 RAPGEF5 RASAL3 RASAL3 SYNGAP1 SYNGAP1 PPP1R14B PPP1R14B RASSF1 RASSF1 ANGPT1 ANGPT1 SOS1 SOS1 CALM1 CALM1 PLCG2 PLCG2 PLAAT2 PLAAT2 RALBP1 RALBP1 CALM2 CALM2 FGF5 FGF5 RAF1 RAF1 EFNA3 EFNA3 ADAM15 ADAM15 NGFR NGFR KSR1 KSR1 PIK3CB PIK3CB KSR2 KSR2 EGF EGF HGF HGF FGF21 FGF21 PLA2G2A PLA2G2A PAK1 PAK1 FGF22 FGF22 EGFR EGFR RELA RELA GNB2 GNB2 H0W027_CAVPO H0W027_CAVPO NTF3 NTF3 H0W0D3_CAVPO H0W0D3_CAVPO LOC100723025 LOC100723025 GNB3 GNB3 RASAL1 RASAL1 EFNA2 EFNA2 PAK6 PAK6 SHC3 SHC3 LAT LAT SHC1 SHC1 PAK4 PAK4 RIN1 RIN1 IKBKG IKBKG FLT3LG FLT3LG H0WBW4_CAVPO H0WBW4_CAVPO NGF NGF NTRK2 NTRK2 PLAAT3 PLAAT3 RRAS2 RRAS2 PLA2G6 PLA2G6 PLA2G2C PLA2G2C RAB5B RAB5B SOS2 SOS2 RAC1 RAC1 GNG3 GNG3 BRAP BRAP Csf1 Csf1 FGF10 FGF10 PAK2 PAK2 PLA2G4A PLA2G4A GNG7 GNG7 LOC100713271 LOC100713271 ANGPT2 ANGPT2 HTR7 HTR7 CALML4 CALML4 PAK3 PAK3 ENSCPOP00000024109 ENSCPOP00000024109 ENSCPOP00000024144 ENSCPOP00000024144 MAPK3 MAPK3 PRKCG PRKCG RASGRP4 RASGRP4 RASGRP2 RASGRP2 MAPK8 MAPK8 GNG2 GNG2 RALB RALB MAPK9 MAPK9 GNG11 GNG11 GNB4 GNB4 FGF1 FGF1 TRBV24-1 TRBV24-1 MRAS MRAS AKT1 AKT1 GNG12 GNG12 FGFR3 FGFR3 TRBV19 TRBV19 RASGRP3 RASGRP3 FOXO4 FOXO4 GRIN1 GRIN1 Gng5 Gng5 PRKACB PRKACB Vegfa Vegfa FGF7 FGF7 PGF PGF RGL1 RGL1 INS INS FGFR2 FGFR2 KITLG KITLG GNG8 GNG8 CALM3 CALM3 IGF2 IGF2 RALA RALA FGF6 FGF6 ENSCPOP00000028279 ENSCPOP00000028279 ENSCPOP00000028400 ENSCPOP00000028400 AFDN AFDN EFNA1 EFNA1 RRAS RRAS ENSCPOP00000028762 ENSCPOP00000028762 RASAL2 RASAL2 ENSCPOP00000028852 ENSCPOP00000028852 ENSCPOP00000029012 ENSCPOP00000029012 ETS1 ETS1 RASGRP1 RASGRP1 GNG4 GNG4 ENSCPOP00000029477 ENSCPOP00000029477 PLA2G2F PLA2G2F VEGFB VEGFB ENSCPOP00000029947 ENSCPOP00000029947 LOC100734206 LOC100734206 ENSCPOP00000030509 ENSCPOP00000030509 BDNF BDNF EPHA2 EPHA2 EFNA4 EFNA4 VEGFC VEGFC Fgf9 Fgf9 RHOA RHOA GNGT2 GNGT2 Faslg Faslg ENSCPOP00000031524 ENSCPOP00000031524 AKT2 AKT2 CDC42 CDC42 Rasa4b Rasa4b RASGRF1 RASGRF1 GRB2 GRB2 FGFR4 FGFR4 STK4 STK4 CSDE1 CSDE1 IGF1 IGF1 GALK2 GALK2 RASSF5 RASSF5 CHUK CHUK ENSCPOP00000032059 ENSCPOP00000032059 PLA2G5 PLA2G5 PDGFA PDGFA Rap1b Rap1b ENSCPOP00000032616 ENSCPOP00000032616 PLA2G1B PLA2G1B HRAS HRAS Prkaca Prkaca PDGFD PDGFD MAPK10 MAPK10 RAP1A RAP1A BCL2L1 BCL2L1 PLCG1 PLCG1 FGF8 FGF8 H0VX85_CAVPO H0VX85_CAVPO PLA2G10 PLA2G10 NTF4 NTF4 RAC2 RAC2 CSF1R CSF1R MAP2K2 MAP2K2 PLA2G12B PLA2G12B AKT3 AKT3 LOC106024982 LOC106024982 RAB17 RAB17 ETS2 ETS2 PRKCA PRKCA FGF17 FGF17 RHOC RHOC CALML3 CALML3 RASA2 RASA2 FGF4 FGF4 RAC3 RAC3 TIAM1 TIAM1 GRIN2A GRIN2A GNB5 GNB5 PTPN11 PTPN11 MET MET PLA2G4E PLA2G4E FLT1 FLT1 ABL2 ABL2 MAPK1 MAPK1 INSR INSR PIK3CD PIK3CD RGL2 RGL2 PDGFC PDGFC PLA2G3 PLA2G3 GAB2 GAB2 GAB1 GAB1 H0VKV0_CAVPO H0VKV0_CAVPO PDGFRA PDGFRA RPS6KL1 RPS6KL1 REL REL KIT KIT Rab5c Rab5c TBK1 TBK1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SHOC2SHOC2 leucine rich repeat scaffold protein. (570 aa)
PLD1Phospholipase. (1064 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
H0VH94_CAVPOIg-like domain-containing protein. (123 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
PLA2G2EPhospholipase A(2). (152 aa)
GNG13G protein subunit gamma 13. (67 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
TEKTEK receptor tyrosine kinase. (1029 aa)
H0VFH9_CAVPOFibrinogen C-terminal domain-containing protein. (480 aa)
TGFATransforming growth factor alpha. (159 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
ELK1ETS transcription factor ELK1. (422 aa)
PLA2G2DPhospholipase A(2). (159 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1343 aa)
RASA1RAS p21 protein activator 1. (1024 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RASA3RAS p21 protein activator 3. (833 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
H0V9U3_CAVPOPhospholipase A(2). (146 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
PLA1APhospholipase A1 member A. (457 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
Shc4Uncharacterized protein. (372 aa)
CEP152Centrosomal protein 152. (1666 aa)
PLA2G4FPhospholipase A2. (842 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLD2Phospholipase. (936 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1199 aa)
NF1Neurofibromin 1. (2750 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
ABL1Tyrosine-protein kinase. (1145 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
BadUncharacterized protein. (166 aa)
GNB1Beta-transducin. (340 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
RAB5ARAB5A, member RAS oncogene family. (214 aa)
RalgdsUncharacterized protein. (906 aa)
ZAP70Tyrosine-protein kinase. (551 aa)
PLA2G12APhospholipase A2 group XIIA. (195 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (348 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (811 aa)
RASAL3RAS protein activator like 3. (1024 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1284 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (108 aa)
RASSF1Ras association domain family member 1. (340 aa)
ANGPT1Angiopoietin 1. (487 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
PLAAT2Phospholipase A and acyltransferase 2. (167 aa)
RALBP1RalA binding protein 1. (634 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (230 aa)
ADAM15ADAM metallopeptidase domain 15. (862 aa)
NGFRNerve growth factor receptor. (429 aa)
KSR1Kinase suppressor of ras 1. (879 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
KSR2Kinase suppressor of ras 2. (938 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PLA2G2APhospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferat [...] (145 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (160 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
GNB2G protein subunit beta 2. (378 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
H0W0D3_CAVPOIg-like domain-containing protein. (126 aa)
LOC100723025Uncharacterized protein. (431 aa)
GNB3G protein subunit beta 3. (340 aa)
RASAL1RAS protein activator like 1. (801 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (190 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SHC3SHC adaptor protein 3. (418 aa)
LATLinker for activation of T cells. (236 aa)
SHC1SHC adaptor protein 1. (583 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
RIN1Ras and Rab interactor 1. (761 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (179 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
RRAS2RAS related 2. (168 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
PLA2G2CPhospholipase A(2). (161 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
BRAPBRCA1 associated protein. (592 aa)
Csf1Uncharacterized protein. (257 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
LOC100713271Uncharacterized protein. (165 aa)
ANGPT2Angiopoietin 2. (494 aa)
HTR75-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (337 aa)
CALML4Calmodulin like 4. (153 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
ENSCPOP00000024109DUF1968 domain-containing protein. (138 aa)
ENSCPOP00000024144Protein kinase domain-containing protein. (110 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
RASGRP4RAS guanyl releasing protein 4. (554 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
RALBRAS like proto-oncogene B. (206 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
TRBV24-1T cell receptor beta variable 24-1. (133 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
RASGRP3RAS guanyl releasing protein 3. (691 aa)
FOXO4Forkhead box O4. (505 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (168 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (802 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CALM3Calmodulin 3. (149 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
RALARAS like proto-oncogene A. (206 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSCPOP00000028279Ig-like domain-containing protein. (134 aa)
ENSCPOP00000028400Ig-like domain-containing protein. (116 aa)
AFDNAfadin, adherens junction formation factor. (1794 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (166 aa)
RRASRAS related. (218 aa)
ENSCPOP00000028762Uncharacterized protein. (107 aa)
RASAL2RAS protein activator like 2. (1280 aa)
ENSCPOP00000028852Phospholipase A(2). (146 aa)
ENSCPOP00000029012Uncharacterized protein. (138 aa)
ETS1ETS proto-oncogene 1, transcription factor. (441 aa)
RASGRP1RAS guanyl releasing protein 1. (796 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSCPOP00000029477Ig-like domain-containing protein. (137 aa)
PLA2G2FPhospholipase A(2). (214 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (206 aa)
ENSCPOP00000029947Phospholipase A(2). (146 aa)
LOC100734206Uncharacterized protein. (461 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
EPHA2EPH receptor A2. (976 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
RHOARas homolog family member A. (193 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
Rasa4bUncharacterized protein. (802 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1261 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
STK4Serine/threonine kinase 4. (487 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
GALK2Galactokinase 2. (458 aa)
RASSF5Ras association domain family member 5. (415 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
PLA2G5Phospholipase A(2). (138 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
Rap1bUncharacterized protein. (184 aa)
ENSCPOP00000032616Ig-like domain-containing protein. (125 aa)
PLA2G1BPhospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (146 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
BCL2L1BCL2 like 1. (233 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
H0VX85_CAVPOUncharacterized protein. (184 aa)
PLA2G10Phospholipase A(2). (152 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (215 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
LOC106024982Phospholipase A2. (795 aa)
RAB17RAB17, member RAS oncogene family. (208 aa)
ETS2ETS proto-oncogene 2, transcription factor. (447 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
RHOCRas homolog family member C. (193 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RASA2RAS p21 protein activator 2. (850 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
RAC3Rac family small GTPase 3. (192 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
GNB5G protein subunit beta 5. (406 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
PLA2G4EPhospholipase A2. (805 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1332 aa)
ABL2Tyrosine-protein kinase. (1157 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (774 aa)
PDGFCPlatelet derived growth factor C. (295 aa)
PLA2G3Phospholipase A2 group III. (645 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
RPS6KL1Ribosomal protein S6 kinase like 1. (634 aa)
RELREL proto-oncogene, NF-kB subunit. (601 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
Rab5cUncharacterized protein. (216 aa)
TBK1TANK binding kinase 1. (729 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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