STRINGSTRING
ENSCPOP00000029477 ENSCPOP00000029477 EGFR EGFR MAP2K3 MAP2K3 FGF22 FGF22 FGF21 FGF21 TLN1 TLN1 HGF HGF VAV3 VAV3 EGF EGF PIK3CB PIK3CB NGFR NGFR ADAM15 ADAM15 EFNA3 EFNA3 RAF1 RAF1 FGF5 FGF5 CALM2 CALM2 MAGI1 MAGI1 CALM1 CALM1 ANGPT1 ANGPT1 ADCY1 ADCY1 RAPGEF5 RAPGEF5 MAP2K1 MAP2K1 PRKD2 PRKD2 PRKCB PRKCB FYB1 FYB1 VEGFD VEGFD RGS14 RGS14 APBB1IP APBB1IP H0V3A7_CAVPO H0V3A7_CAVPO H0V3F2_CAVPO H0V3F2_CAVPO GPR55 GPR55 PRKD1 PRKD1 Ralgds Ralgds FGF2 FGF2 PDGFB PDGFB IGF1R IGF1R PTRHD1 PTRHD1 ADCY3 ADCY3 FGF23 FGF23 ACTL7A ACTL7A PDGFRB PDGFRB GRIN2B GRIN2B FGF18 FGF18 FGFR1 FGFR1 PIK3CA PIK3CA ITGA2B ITGA2B CRK CRK ENAH ENAH MAGI3 MAGI3 ITGAL ITGAL ADCY8 ADCY8 FGF3 FGF3 PIK3R1 PIK3R1 FGF16 FGF16 FLT4 FLT4 FGF19 FGF19 H0VE70_CAVPO H0VE70_CAVPO DRD2 DRD2 EFNA5 EFNA5 PFN4 PFN4 PLCE1 PLCE1 H0VFH9_CAVPO H0VFH9_CAVPO TEK TEK KDR KDR VASP VASP Rapgef6 Rapgef6 H0VH94_CAVPO H0VH94_CAVPO RAPGEF4 RAPGEF4 FGF20 FGF20 NRAS NRAS KRAS KRAS PARD6A PARD6A ADCY2 ADCY2 Itgb3 Itgb3 KIT KIT GNAI3 GNAI3 RPS6KL1 RPS6KL1 PDGFRA PDGFRA CDH1 CDH1 H0VKV0_CAVPO H0VKV0_CAVPO PRKD3 PRKD3 ARAP3 ARAP3 DOCK4 DOCK4 PDGFC PDGFC PIK3CD PIK3CD INSR INSR MAPK1 MAPK1 FARP2 FARP2 FLT1 FLT1 MET MET GRIN2A GRIN2A TIAM1 TIAM1 PRKCZ PRKCZ RAC3 RAC3 FGF4 FGF4 ADCY5 ADCY5 CALML3 CALML3 ADCY4 ADCY4 RHOC RHOC MAPK13 MAPK13 FGF17 FGF17 THBS1 THBS1 MAPK12 MAPK12 PRKCA PRKCA PRKCI PRKCI MAGI2 MAGI2 AKT3 AKT3 PARD3 PARD3 MAP2K2 MAP2K2 P2RY1 P2RY1 H0VUM6_CAVPO H0VUM6_CAVPO PFN3 PFN3 H0VVE5_CAVPO H0VVE5_CAVPO CSF1R CSF1R RAC2 RAC2 ITGB2 ITGB2 ACTRT2 ACTRT2 H0VWH7_CAVPO H0VWH7_CAVPO H0VX85_CAVPO H0VX85_CAVPO FGF8 FGF8 PLCG1 PLCG1 H0VXT9_CAVPO H0VXT9_CAVPO H0VYG8_CAVPO H0VYG8_CAVPO H0W027_CAVPO H0W027_CAVPO H0W0B4_CAVPO H0W0B4_CAVPO H0W0D3_CAVPO H0W0D3_CAVPO H0W1P6_CAVPO H0W1P6_CAVPO P2RY11 P2RY11 ACTL7B ACTL7B RAPGEF1 RAPGEF1 ACTRT1 ACTRT1 EFNA2 EFNA2 H0W3Y7_CAVPO H0W3Y7_CAVPO LOC101787807 LOC101787807 TLNRD1 TLNRD1 H0W5D4_CAVPO H0W5D4_CAVPO LOC100725331 LOC100725331 LAT LAT LOC100731872 LOC100731872 H0W7V2_CAVPO H0W7V2_CAVPO ACTL9 ACTL9 ACTL8 ACTL8 H0W9K9_CAVPO H0W9K9_CAVPO CNR1 CNR1 SKAP1 SKAP1 NGF NGF PARD6B PARD6B H0WD09_CAVPO H0WD09_CAVPO ADORA2A ADORA2A PLCB3 PLCB3 LOC100732158 LOC100732158 SIPA1L3 SIPA1L3 ENSCPOP00000022108 ENSCPOP00000022108 ACTB ACTB MAP2K6 MAP2K6 RAC1 RAC1 MAPK14 MAPK14 Csf1 Csf1 FGF10 FGF10 ENSCPOP00000022761 ENSCPOP00000022761 CTNND1 CTNND1 PLCB1 PLCB1 TLN2 TLN2 LOC100713271 LOC100713271 ANGPT2 ANGPT2 ADORA2B ADORA2B VAV2 VAV2 CALML4 CALML4 LPAR1 LPAR1 ENSCPOP00000024109 ENSCPOP00000024109 MAPK11 MAPK11 MAPK3 MAPK3 PRKCG PRKCG RASGRP2 RASGRP2 F2RL3 F2RL3 F2R F2R RAPGEF3 RAPGEF3 GNAO1 GNAO1 RALB RALB PARD6G PARD6G GNAI2 GNAI2 ENSCPOP00000025438 ENSCPOP00000025438 RGS12 RGS12 FGF1 FGF1 RAP1GAP RAP1GAP ADCY9 ADCY9 ITGAM ITGAM TRBV24-1 TRBV24-1 MRAS MRAS AKT1 AKT1 LCP2 LCP2 FGFR3 FGFR3 TRBV19 TRBV19 RASGRP3 RASGRP3 GRIN1 GRIN1 Vegfa Vegfa GNAQ GNAQ FGF7 FGF7 PGF PGF Rap1gap2 Rap1gap2 EVL EVL INS INS FGFR2 FGFR2 BCAR1 BCAR1 KITLG KITLG ID1 ID1 ADCY6 ADCY6 ADCY7 ADCY7 CALM3 CALM3 CRKL CRKL ENSCPOP00000027886 ENSCPOP00000027886 RALA RALA ENSCPOP00000028111 ENSCPOP00000028111 FGF6 FGF6 ENSCPOP00000028279 ENSCPOP00000028279 ENSCPOP00000028355 ENSCPOP00000028355 ENSCPOP00000028400 ENSCPOP00000028400 AFDN AFDN EFNA1 EFNA1 RRAS RRAS ENSCPOP00000028762 ENSCPOP00000028762 ENSCPOP00000029012 ENSCPOP00000029012 PLCB4 PLCB4 PLCB2 PLCB2 PFN2 PFN2 PFN1 PFN1 SIPA1 SIPA1 VEGFB VEGFB ENSCPOP00000029904 ENSCPOP00000029904 GNAI1 GNAI1 LOC100734206 LOC100734206 SIPA1L1 SIPA1L1 ACTG1 ACTG1 EPHA2 EPHA2 EFNA4 EFNA4 LPAR2 LPAR2 VEGFC VEGFC Fgf9 Fgf9 LPAR3 LPAR3 RHOA RHOA LOC100732436 LOC100732436 AKT2 AKT2 CDC42 CDC42 BRAF BRAF Krit1 Krit1 FGFR4 FGFR4 ITGB1 ITGB1 Rapgef2 Rapgef2 CSDE1 CSDE1 IGF1 IGF1 GALK2 GALK2 RASSF5 RASSF5 ENSCPOP00000032025 ENSCPOP00000032025 ENSCPOP00000032059 ENSCPOP00000032059 ENSCPOP00000032481 ENSCPOP00000032481 PDGFA PDGFA SIPA1L2 SIPA1L2 Rap1b Rap1b ENSCPOP00000032616 ENSCPOP00000032616 CTNNB1 CTNNB1 HRAS HRAS PDGFD PDGFD RAP1A RAP1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ENSCPOP00000029477Ig-like domain-containing protein. (137 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (160 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
TLN1Talin 1. (2537 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
NGFRNerve growth factor receptor. (429 aa)
ADAM15ADAM metallopeptidase domain 15. (862 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (230 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
MAGI1Membrane associated guanylate kinase, WW and PDZ domain containing 1. (1181 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
ANGPT1Angiopoietin 1. (487 aa)
ADCY1Adenylate cyclase 1. (944 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (811 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (865 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
FYB1FYN binding protein 1. (823 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (348 aa)
RGS14Regulator of G protein signaling 14. (570 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (611 aa)
H0V3A7_CAVPOUncharacterized protein. (1320 aa)
H0V3F2_CAVPOUncharacterized protein. (1365 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (313 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
RalgdsUncharacterized protein. (906 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1007 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
ENAHENAH actin regulator. (768 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1394 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1170 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1343 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
H0VFH9_CAVPOFibrinogen C-terminal domain-containing protein. (480 aa)
TEKTEK receptor tyrosine kinase. (1029 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (376 aa)
Rapgef6Uncharacterized protein. (1587 aa)
H0VH94_CAVPOIg-like domain-containing protein. (123 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
RPS6KL1Ribosomal protein S6 kinase like 1. (634 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1543 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1970 aa)
PDGFCPlatelet derived growth factor C. (295 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1052 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1332 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (593 aa)
RAC3Rac family small GTPase 3. (192 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
RHOCRas homolog family member C. (193 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
THBS1Thrombospondin 1. (1163 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (572 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1237 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
PARD3Par-3 family cell polarity regulator. (1294 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
P2RY1P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation. Belongs to the G-protein coupled receptor 1 family. (373 aa)
H0VUM6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (552 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
H0VVE5_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (528 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
ITGB2Integrin beta. (767 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (376 aa)
H0VWH7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (441 aa)
H0VX85_CAVPOUncharacterized protein. (184 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
H0VXT9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (546 aa)
H0VYG8_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
H0W0B4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (639 aa)
H0W0D3_CAVPOIg-like domain-containing protein. (126 aa)
H0W1P6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
P2RY11Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (408 aa)
ACTL7BActin like 7B; Belongs to the actin family. (412 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1263 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (190 aa)
H0W3Y7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (503 aa)
LOC101787807Profilin; Belongs to the profilin family. (153 aa)
TLNRD1Talin rod domain containing 1. (355 aa)
H0W5D4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
LOC100725331Uncharacterized protein. (1433 aa)
LATLinker for activation of T cells. (236 aa)
LOC100731872Uncharacterized protein; Belongs to the actin family. (1226 aa)
H0W7V2_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (555 aa)
ACTL9Actin like 9; Belongs to the actin family. (388 aa)
ACTL8Actin like 8; Belongs to the actin family. (371 aa)
H0W9K9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
SKAP1Src kinase associated phosphoprotein 1. (365 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
PARD6BPar-6 family cell polarity regulator beta. (357 aa)
H0WD09_CAVPONon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (323 aa)
ADORA2AAdenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). (409 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
LOC100732158Uncharacterized protein. (246 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1774 aa)
ENSCPOP00000022108Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Csf1Uncharacterized protein. (257 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSCPOP00000022761Uncharacterized protein; Belongs to the protein kinase superfamily. (451 aa)
CTNND1Catenin delta 1. (966 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
TLN2Talin 2. (2542 aa)
LOC100713271Uncharacterized protein. (165 aa)
ANGPT2Angiopoietin 2. (494 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (221 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
CALML4Calmodulin like 4. (153 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSCPOP00000024109DUF1968 domain-containing protein. (138 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (381 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
GNAO1G protein subunit alpha o1. (318 aa)
RALBRAS like proto-oncogene B. (206 aa)
PARD6GPar-6 family cell polarity regulator gamma. (382 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
ENSCPOP00000025438Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
RGS12Regulator of G protein signaling 12. (1431 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
RAP1GAPRAP1 GTPase activating protein. (744 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
TRBV24-1T cell receptor beta variable 24-1. (133 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LCP2Lymphocyte cytosolic protein 2. (570 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
RASGRP3RAS guanyl releasing protein 3. (691 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
GNAQG protein subunit alpha q. (313 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (168 aa)
Rap1gap2RAP1 GTPase activating protein 2. (744 aa)
EVLEnah/Vasp-like; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (420 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (879 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (151 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
CALM3Calmodulin 3. (149 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ENSCPOP00000027886Uncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
RALARAS like proto-oncogene A. (206 aa)
ENSCPOP00000028111Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSCPOP00000028279Ig-like domain-containing protein. (134 aa)
ENSCPOP00000028355Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
ENSCPOP00000028400Ig-like domain-containing protein. (116 aa)
AFDNAfadin, adherens junction formation factor. (1794 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (166 aa)
RRASRAS related. (218 aa)
ENSCPOP00000028762Uncharacterized protein. (107 aa)
ENSCPOP00000029012Uncharacterized protein. (138 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PFN2Profilin; Belongs to the profilin family. (140 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
SIPA1Signal-induced proliferation-associated 1. (1040 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (206 aa)
ENSCPOP00000029904Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (633 aa)
GNAI1Uncharacterized protein. (330 aa)
LOC100734206Uncharacterized protein. (461 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1803 aa)
ACTG1Actin gamma 1. (375 aa)
EPHA2EPH receptor A2. (976 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
Fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (91 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa)
RHOARas homolog family member A. (193 aa)
LOC100732436Uncharacterized protein. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
Krit1Uncharacterized protein. (736 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
Rapgef2Uncharacterized protein. (1640 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
GALK2Galactokinase 2. (458 aa)
RASSF5Ras association domain family member 5. (415 aa)
ENSCPOP00000032025Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
ENSCPOP00000032481Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
SIPA1L2Signal induced proliferation associated 1 like 2. (1720 aa)
Rap1bUncharacterized protein. (184 aa)
ENSCPOP00000032616Ig-like domain-containing protein. (125 aa)
CTNNB1Catenin beta 1. (781 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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