STRINGSTRING
TACR1 TACR1 AVPR1A AVPR1A ENSCPOP00000031130 ENSCPOP00000031130 ADRA1A ADRA1A MYLK2 MYLK2 ENSCPOP00000031332 ENSCPOP00000031332 LOC100732436 LOC100732436 AVPR1B AVPR1B ENSCPOP00000031748 ENSCPOP00000031748 PPP3R1 PPP3R1 LRRN4CL LRRN4CL ENSCPOP00000032059 ENSCPOP00000032059 CASQ2 CASQ2 CACNA1D CACNA1D CASQ1 CASQ1 PDGFA PDGFA ENSCPOP00000032517 ENSCPOP00000032517 ENSCPOP00000032616 ENSCPOP00000032616 HTR2A HTR2A HRH2 HRH2 TBXA2R TBXA2R Prkaca Prkaca PDGFD PDGFD ADCY7 ADCY7 CALM3 CALM3 RYR3 RYR3 ENSCPOP00000028279 ENSCPOP00000028279 ENSCPOP00000028400 ENSCPOP00000028400 Ltb4r2 Ltb4r2 ENSCPOP00000028569 ENSCPOP00000028569 Vdac1 Vdac1 PTAFR PTAFR OXTR OXTR ENSCPOP00000028990 ENSCPOP00000028990 ENSCPOP00000029012 ENSCPOP00000029012 SLC8A3 SLC8A3 PLCB4 PLCB4 PTGFR PTGFR Chrna7 Chrna7 ENSCPOP00000029145 ENSCPOP00000029145 ENSCPOP00000029147 ENSCPOP00000029147 P2RX1 P2RX1 PDE1C PDE1C PLCB2 PLCB2 ENSCPOP00000029468 ENSCPOP00000029468 ENSCPOP00000029477 ENSCPOP00000029477 ATP2C1 ATP2C1 OSBPL9 OSBPL9 ENSCPOP00000029769 ENSCPOP00000029769 ORAI2 ORAI2 HTR2C HTR2C PTK2B PTK2B ITPR1 ITPR1 Camk2d Camk2d ATP2B3 ATP2B3 ENSCPOP00000030754 ENSCPOP00000030754 ENSCPOP00000030758 ENSCPOP00000030758 PDE1A PDE1A NOS2 NOS2 EGFR EGFR MYLK4 MYLK4 PHKG1 PHKG1 HTR2B HTR2B GRPR GRPR H0UU35_CAVPO H0UU35_CAVPO PLCD1 PLCD1 EGF EGF TRDC TRDC PPP3CC PPP3CC GRIN2C GRIN2C QRFPR QRFPR CALM2 CALM2 HTR6 HTR6 SLC25A31 SLC25A31 ATP2A1 ATP2A1 CYSLTR1 CYSLTR1 Mcub Mcub PLCG2 PLCG2 SLC8A1 SLC8A1 CALM1 CALM1 TPCN2 TPCN2 ADCY1 ADCY1 ITPKA ITPKA GNAL GNAL CHRM5 CHRM5 TNNC1 TNNC1 STIM2 STIM2 PRKCB PRKCB HRC HRC H0V1A0_CAVPO H0V1A0_CAVPO GRM1 GRM1 MYLK3 MYLK3 P2rx4 P2rx4 CAMK1G CAMK1G NOS3 NOS3 CACNA1B CACNA1B EDNRA EDNRA MYLK MYLK Gna15 Gna15 SLC25A4 SLC25A4 GNA14 GNA14 PDGFB PDGFB TPCN1 TPCN1 PTRHD1 PTRHD1 ADCY3 ADCY3 ERBB2 ERBB2 STK33 STK33 PDGFRB PDGFRB TACR2 TACR2 H0V789_CAVPO H0V789_CAVPO PHKB PHKB CAMK2A CAMK2A PLCZ1 PLCZ1 MCOLN2 MCOLN2 CCKAR CCKAR CAMK4 CAMK4 PLCD3 PLCD3 ADCY8 ADCY8 ASPH ASPH ATP2A3 ATP2A3 AGTR1 AGTR1 ZRANB2 ZRANB2 HTR5A HTR5A PPP3CB PPP3CB CAMK1 CAMK1 GRM5 GRM5 ITPKC ITPKC SLC25A5 SLC25A5 H0VE70_CAVPO H0VE70_CAVPO PLCE1 PLCE1 MCOLN1 MCOLN1 PPP3CA PPP3CA SLC8A2 SLC8A2 VDAC3 VDAC3 H0VH94_CAVPO H0VH94_CAVPO ADCY2 ADCY2 ERBB4 ERBB4 TRHR TRHR PDGFRA PDGFRA CACNA1I CACNA1I H0VKV0_CAVPO H0VKV0_CAVPO SPHK1 SPHK1 CACNA1H CACNA1H HTR4 HTR4 ITPR2 ITPR2 PDGFC PDGFC P2RX6 P2RX6 ITPKB ITPKB GRIN2A GRIN2A P2RX2 P2RX2 PPIF PPIF PSKH1 PSKH1 CALML3 CALML3 ADCY4 ADCY4 H0VR18_CAVPO H0VR18_CAVPO CHRM2 CHRM2 ERBB3 ERBB3 CACNA1E CACNA1E PRKCA PRKCA PDE1B PDE1B PLCD4 PLCD4 EDNRB EDNRB P2rx5 P2rx5 MCU MCU RYR1 RYR1 Lhcgr Lhcgr TNNC2 TNNC2 BSCL2 BSCL2 TACR3 TACR3 CYSLTR2 CYSLTR2 P2RX3 P2RX3 PLCG1 PLCG1 H0VXJ2_CAVPO H0VXJ2_CAVPO OTOP1 OTOP1 CCKBR CCKBR H0VZI8_CAVPO H0VZI8_CAVPO H0W0D3_CAVPO H0W0D3_CAVPO H0WDE0_CAVPO H0WDE0_CAVPO EFCAB3 EFCAB3 CACNA1S CACNA1S ADORA2A ADORA2A PLCB3 PLCB3 GNA11 GNA11 LOC100732158 LOC100732158 ENSCPOP00000022167 ENSCPOP00000022167 ENSCPOP00000022622 ENSCPOP00000022622 ENSCPOP00000022635 ENSCPOP00000022635 ORAI3 ORAI3 PHKA2 PHKA2 ATP2B1 ATP2B1 ADRA1D ADRA1D CAMK2G CAMK2G CACNA1C CACNA1C CAMKV CAMKV RCSD1 RCSD1 MCOLN3 MCOLN3 PLCB1 PLCB1 ATP2B4 ATP2B4 ENSCPOP00000023578 ENSCPOP00000023578 ENSCPOP00000023636 ENSCPOP00000023636 ADORA2B ADORA2B HTR7 HTR7 ENSCPOP00000023749 ENSCPOP00000023749 CALML4 CALML4 ENSCPOP00000023778 ENSCPOP00000023778 ENSCPOP00000023913 ENSCPOP00000023913 ENSCPOP00000024109 ENSCPOP00000024109 H0VVB6_CAVPO H0VVB6_CAVPO ATP2A2 ATP2A2 PRKCG PRKCG CAMK1D CAMK1D ENSCPOP00000024624 ENSCPOP00000024624 F2R F2R PHKA1 PHKA1 LOC100714922 LOC100714922 PTGER1 PTGER1 DRD1 DRD1 NOS1 NOS1 ENSCPOP00000025410 ENSCPOP00000025410 SPHK2 SPHK2 ENSCPOP00000025793 ENSCPOP00000025793 ADCY9 ADCY9 STIM1 STIM1 VDAC2 VDAC2 TRBV24-1 TRBV24-1 ENSCPOP00000026228 ENSCPOP00000026228 PLN PLN TRBV19 TRBV19 PTGER3 PTGER3 GRIN1 GRIN1 PRKACB PRKACB GNAQ GNAQ TRDN TRDN ENSCPOP00000027199 ENSCPOP00000027199 CXCR4 CXCR4 GRIN2D GRIN2D RYR2 RYR2 LOC100729898 LOC100729898 CACNA1G CACNA1G LOC100718831 LOC100718831 BDKRB2 BDKRB2 ADRA1B ADRA1B Gpr150 Gpr150 DRD5 DRD5 H0WAR2_CAVPO H0WAR2_CAVPO H0WAH0_CAVPO H0WAH0_CAVPO CACNA1A CACNA1A ITPR3 ITPR3 H0W813_CAVPO H0W813_CAVPO PHKG2 PHKG2 CHRM1 CHRM1 ARSI ARSI H0W6K2_CAVPO H0W6K2_CAVPO ORAI1 ORAI1 P2rx7 P2rx7 ADRB2 ADRB2 CACNA1F CACNA1F ATP2B2 ATP2B2 ADRB1 ADRB1 TRGC1 TRGC1 ATP2C2 ATP2C2 HRH1 HRH1 Chrm3 Chrm3 CAMK2B CAMK2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TACR1Substance-P receptor; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. (407 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa)
ENSCPOP00000031130Ig-like domain-containing protein. (136 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
MYLK2Myosin light chain kinase 2. (593 aa)
ENSCPOP00000031332Ig-like domain-containing protein. (138 aa)
LOC100732436Uncharacterized protein. (327 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa)
ENSCPOP00000031748Ig-like domain-containing protein. (136 aa)
PPP3R1Uncharacterized protein. (169 aa)
LRRN4CLLRRN4 C-terminal like. (226 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
ENSCPOP00000032517Ig-like domain-containing protein. (129 aa)
ENSCPOP00000032616Ig-like domain-containing protein. (125 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
HRH2Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (422 aa)
TBXA2RThromboxane A2 receptor. (347 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
CALM3Calmodulin 3. (149 aa)
RYR3Ryanodine receptor 3. (4843 aa)
ENSCPOP00000028279Ig-like domain-containing protein. (134 aa)
ENSCPOP00000028400Ig-like domain-containing protein. (116 aa)
Ltb4r2G_PROTEIN_RECEP_F1_2 domain-containing protein. (360 aa)
ENSCPOP00000028569ANF_receptor domain-containing protein. (260 aa)
Vdac1Uncharacterized protein. (283 aa)
PTAFRPlatelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. (342 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (390 aa)
ENSCPOP00000028990Ig-like domain-containing protein. (138 aa)
ENSCPOP00000029012Uncharacterized protein. (138 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (365 aa)
Chrna7Uncharacterized protein. (483 aa)
ENSCPOP00000029145Ig-like domain-containing protein. (136 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PDE1CPhosphodiesterase. (685 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSCPOP00000029468Ig-like domain-containing protein. (122 aa)
ENSCPOP00000029477Ig-like domain-containing protein. (137 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (977 aa)
OSBPL9Oxysterol-binding protein; Belongs to the OSBP family. (746 aa)
ENSCPOP00000029769Ig-like domain-containing protein. (139 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (307 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1226 aa)
ENSCPOP00000030754Ig-like domain-containing protein. (139 aa)
ENSCPOP00000030758Ig-like domain-containing protein. (122 aa)
PDE1APhosphodiesterase. (531 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1149 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (386 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (388 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
H0UU35_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein. (359 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
TRDCT cell receptor delta constant. (140 aa)
PPP3CCSerine/threonine-protein phosphatase. (481 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
QRFPRPyroglutamylated RFamide peptide receptor; Belongs to the G-protein coupled receptor 1 family. (431 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (437 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (322 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
CYSLTR1Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). (340 aa)
McubMCU domain-containing protein. (195 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
TPCN2Two pore channel 2. (752 aa)
ADCY1Adenylate cyclase 1. (944 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
GNALG protein subunit alpha L. (372 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (530 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
STIM2Stromal interaction molecule 2. (742 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
HRCHistidine rich calcium binding protein. (674 aa)
H0V1A0_CAVPOYccV-like domain-containing protein. (541 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
MYLK3Myosin light chain kinase 3. (811 aa)
P2rx4Uncharacterized protein. (343 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (478 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
MYLKMyosin light chain kinase. (1959 aa)
Gna15Uncharacterized protein. (205 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
GNA14G protein subunit alpha 14. (356 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
TPCN1Two pore channel 1. (817 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
STK33Serine/threonine kinase 33; Belongs to the protein kinase superfamily. (461 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
TACR2Substance-K receptor; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (402 aa)
H0V789_CAVPOIg-like domain-containing protein. (126 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1075 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PLCZ1Phosphoinositide phospholipase C. (601 aa)
MCOLN2Mucolipin 2. (540 aa)
CCKARCholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (430 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
ASPHAspartate beta-hydroxylase. (644 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (359 aa)
ZRANB2Zinc finger Ran-binding domain-containing protein 2; May interfere with constitutive 5'-splice site selection. Belongs to the ZRANB2 family. (328 aa)
HTR5A5-hydroxytryptamine receptor 5A. (356 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
GRM5Glutamate metabotropic receptor 5. (873 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (679 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
MCOLN1Mucolipin 1. (582 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
VDAC3Voltage dependent anion channel 3. (283 aa)
H0VH94_CAVPOIg-like domain-containing protein. (123 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
TRHRThyrotropin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
SPHK1Sphingosine kinase 1. (386 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
HTR45-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity); Belongs to the G-protein coupled receptor 1 family. (388 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
PDGFCPlatelet derived growth factor C. (295 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (890 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
PSKH1Protein serine kinase H1; Belongs to the protein kinase superfamily. (424 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
H0VR18_CAVPOIg-like domain-containing protein. (136 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
PDE1BPhosphodiesterase. (535 aa)
PLCD4Phosphoinositide phospholipase C. (762 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
P2rx5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (456 aa)
MCUMitochondrial calcium uniporter. (344 aa)
RYR1Ryanodine receptor 1. (4554 aa)
LhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (691 aa)
TNNC2Troponin C2, fast skeletal type. (160 aa)
BSCL2BSCL2 lipid droplet biogenesis associated, seipin. (366 aa)
TACR3Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (404 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (317 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
OTOP1Otopetrin 1. (578 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
H0VZI8_CAVPOIg-like domain-containing protein. (123 aa)
H0W0D3_CAVPOIg-like domain-containing protein. (126 aa)
H0WDE0_CAVPOIg-like domain-containing protein. (118 aa)
EFCAB3EF-hand calcium binding domain 3. (436 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
ADORA2AAdenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). (409 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
LOC100732158Uncharacterized protein. (246 aa)
ENSCPOP00000022167Ig-like domain-containing protein. (174 aa)
ENSCPOP00000022622Ig-like domain-containing protein. (129 aa)
ENSCPOP00000022635Uncharacterized protein. (311 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (297 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1235 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
ADRA1DAdrenoceptor alpha 1D. (478 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
CAMKVCaM kinase like vesicle associated. (506 aa)
RCSD1RCSD domain containing 1. (408 aa)
MCOLN3Mucolipin 3. (553 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
ENSCPOP00000023578Ig-like domain-containing protein. (129 aa)
ENSCPOP00000023636Ig-like domain-containing protein. (129 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (221 aa)
HTR75-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (337 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
CALML4Calmodulin like 4. (153 aa)
ENSCPOP00000023778Ig-like domain-containing protein. (179 aa)
ENSCPOP00000023913Ig-like domain-containing protein. (122 aa)
ENSCPOP00000024109DUF1968 domain-containing protein. (138 aa)
H0VVB6_CAVPOIg-like domain-containing protein. (137 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (381 aa)
ENSCPOP00000024624Uncharacterized protein. (493 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
PTGER1Prostaglandin E receptor 1. (405 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
NOS1Nitric oxide synthase 1. (1465 aa)
ENSCPOP00000025410Ig-like domain-containing protein. (118 aa)
SPHK2Sphingosine kinase 2. (655 aa)
ENSCPOP00000025793Ig-like domain-containing protein. (146 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
STIM1Stromal interaction molecule 1. (713 aa)
VDAC2Voltage dependent anion channel 2. (294 aa)
TRBV24-1T cell receptor beta variable 24-1. (133 aa)
ENSCPOP00000026228Ig-like domain-containing protein. (134 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
TRDNTriadin. (682 aa)
ENSCPOP00000027199Ig-like domain-containing protein. (128 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
RYR2Ryanodine receptor 2. (4910 aa)
LOC100729898G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
LOC100718831YccV-like domain-containing protein. (514 aa)
BDKRB2B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (399 aa)
ADRA1BAdrenoceptor alpha 1B. (520 aa)
Gpr150Uncharacterized protein. (388 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
H0WAR2_CAVPOIg-like domain-containing protein. (139 aa)
H0WAH0_CAVPOIg-like domain-containing protein. (121 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
H0W813_CAVPOUncharacterized protein. (753 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
ARSIArylsulfatase family member I. (572 aa)
H0W6K2_CAVPOIg-like domain-containing protein. (135 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
TRGC1Ig-like domain-containing protein. (166 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (945 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (24%) [HD]