Your Input: | |
| | NPPA | Cardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | AKT3 | AKT serine/threonine kinase 3. (470 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa) |
| | MKNK2 | MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa) |
| | Arnt | Uncharacterized protein. (775 aa) |
| | EGLN3 | Egl-9 family hypoxia inducible factor 3. (239 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1332 aa) |
| | ENO3 | Enolase 3. (434 aa) |
| | TIMP1 | TIMP metallopeptidase inhibitor 1. (207 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (325 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1371 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (465 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa) |
| | ALDOB | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa) |
| | LDHC | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | ENO4 | Enolase 4. (615 aa) |
| | LTF | Lactotransferrin; Belongs to the transferrin family. (712 aa) |
| | HK3 | Hexokinase 3. (864 aa) |
| | TEK | TEK receptor tyrosine kinase. (1029 aa) |
| | H0VFH9_CAVPO | Fibrinogen C-terminal domain-containing protein. (480 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (350 aa) |
| | Pdha1 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa) |
| | HK2 | Hexokinase 2. (917 aa) |
| | PFKM | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (967 aa) |
| | Aldoa | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa) |
| | PDHB | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa) |
| | HK1 | Hexokinase 1. (919 aa) |
| | ENO2 | Enolase 2. (434 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1256 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (828 aa) |
| | EIF4E1B | Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (246 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa) |
| | Rps6 | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) |
| | EGLN2 | Egl-9 family hypoxia inducible factor 2. (410 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ANGPT1 | Angiopoietin 1. (487 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa) |
| | CYBB | Cytochrome b-245 beta chain. (570 aa) |
| | CUL2 | Cullin 2; Belongs to the cullin family. (745 aa) |
| | PFKP | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (792 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | EIF4E2 | Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa) |
| | Gapdh | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (353 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa) |
| | CREBBP | CREB binding protein. (2441 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |
| | Camk2d | Protein kinase domain-containing protein. (532 aa) |
| | LOC100734206 | Uncharacterized protein. (461 aa) |
| | LTBR | Lymphotoxin beta receptor. (417 aa) |
| | Mknk1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa) |
| | PGK1 | Phosphoglycerate kinase. (417 aa) |
| | EIF4E | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa) |
| | Ldhb | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa) |
| | TBCA | Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa) |
| | HKDC1 | Hexokinase domain containing 1. (917 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) |
| | TFRC | Transferrin receptor protein 1. (765 aa) |
| | Vegfa | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa) |
| | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (549 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (169 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | LDHA | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | LOC111753928 | Uncharacterized protein. (139 aa) |
| | ENSCPOP00000023919 | Uncharacterized protein. (118 aa) |
| | RPS6KB2 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa) |
| | LOC100721922 | Uncharacterized protein; Belongs to the transferrin family. (700 aa) |
| | ENO1 | Alpha-enolase. (434 aa) |
| | ANGPT2 | Angiopoietin 2. (494 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (476 aa) |
| | CAMK2G | Calcium/calmodulin dependent protein kinase II gamma. (545 aa) |
| | IL6R | Interleukin 6 receptor. (450 aa) |
| | PDK1 | Protein-serine/threonine kinase. (436 aa) |
| | Fcgbp | Uncharacterized protein. (2613 aa) |
| | PFKL | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa) |
| | HMOX1 | Heme oxygenase 1. (297 aa) |
| | H0W7V4_CAVPO | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa) |
| | Vhl | Uncharacterized protein. (182 aa) |
| | Elob | Ubiquitin-like domain-containing protein. (118 aa) |
| | H0W774_CAVPO | 40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (227 aa) |
| | ARSI | Arylsulfatase family member I. (572 aa) |
| | H0W5C1_CAVPO | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa) |
| | ALDOC | Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa) |
| | BCL2 | BCL2 apoptosis regulator. (183 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (659 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1149 aa) |
| | Egln1 | Fe2OG dioxygenase domain-containing protein. (127 aa) |
| | H0W027_CAVPO | Uncharacterized protein. (722 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (549 aa) |
