STRINGSTRING
RRAD RRAD CALCOCO2 CALCOCO2 Foxo3 Foxo3 H0W276_CAVPO H0W276_CAVPO CITED4 CITED4 Phf23 Phf23 RELA RELA HIF3A HIF3A ATF4 ATF4 PINK1 PINK1 FUNDC2 FUNDC2 MITF MITF ATG5 ATG5 EIF2AK3 EIF2AK3 USP30 USP30 TFEC TFEC USP11 USP11 PDIK1L PDIK1L TBK1 TBK1 CSNK2B CSNK2B RASL11B RASL11B KRAS KRAS NRAS NRAS USP4 USP4 USP19 USP19 GEM GEM RIT2 RIT2 CSNK2A2 CSNK2A2 TOMM7 TOMM7 OPTN OPTN NPAS3 NPAS3 GABARAPL1 GABARAPL1 AGFG2 AGFG2 PRKN PRKN Rps27a Rps27a Csnk2a1 Csnk2a1 Usp32 Usp32 HIF1A HIF1A TBC1D17 TBC1D17 RIT1 RIT1 TBC1D15 TBC1D15 ATG9B ATG9B CITED2 CITED2 LOC100723477 LOC100723477 USP8 USP8 TAX1BP1 TAX1BP1 FIS1 FIS1 SP1 SP1 Atg9a Atg9a H0WAD6_CAVPO H0WAD6_CAVPO NBR1 NBR1 NPAS1 NPAS1 JUN JUN H0WDT2_CAVPO H0WDT2_CAVPO RRAS2 RRAS2 SPEN SPEN USP31 USP31 FUNDC1 FUNDC1 STK35 STK35 USP43 USP43 BNIP3L BNIP3L SQSTM1 SQSTM1 MAPK8 MAPK8 MAPK9 MAPK9 MFN1 MFN1 RAB7B RAB7B ENSCPOP00000025880 ENSCPOP00000025880 MRAS MRAS TFEB TFEB E2F1 E2F1 CFAP70 CFAP70 GABARAPL2 GABARAPL2 Ly6g5b Ly6g5b ULK1 ULK1 RRAS RRAS AMBRA1 AMBRA1 PGAM5 PGAM5 BNIP3 BNIP3 TP53 TP53 UBB UBB ENSCPOP00000030352 ENSCPOP00000030352 AGFG1 AGFG1 TFE3 TFE3 RHOT1 RHOT1 BECN1 BECN1 ENSCPOP00000031632 ENSCPOP00000031632 REM1 REM1 CSDE1 CSDE1 Ubc Ubc HRAS HRAS RAB7A RAB7A MFN2 MFN2 MAPK10 MAPK10 BCL2L1 BCL2L1 USP15 USP15 UBA52 UBA52 BCL2L13 BCL2L13 REM2 REM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (443 aa)
Foxo3Forkhead box O3. (660 aa)
H0W276_CAVPOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
CITED4Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4. (183 aa)
Phf23Uncharacterized protein. (56 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (667 aa)
ATF4Activating transcription factor 4. (354 aa)
PINK1PTEN induced kinase 1. (574 aa)
FUNDC2FUN14 domain containing 2. (151 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1112 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
TFECTranscription factor EC. (345 aa)
USP11Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (917 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (418 aa)
TBK1TANK binding kinase 1. (729 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (244 aa)
RASL11BRAS like family 11 member B. (234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (965 aa)
USP19Ubiquitin specific peptidase 19. (1355 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
RIT2Ras like without CAAX 2. (216 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (349 aa)
TOMM7Translocase of outer mitochondrial membrane 7. (55 aa)
OPTNOptineurin. (576 aa)
NPAS3Neuronal PAS domain protein 3. (769 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa)
AGFG2ArfGAP with FG repeats 2. (478 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (443 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
Usp32Uncharacterized protein; Belongs to the peptidase C19 family. (1537 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
TBC1D17TBC1 domain family member 17. (646 aa)
RIT1Ras like without CAAX 1. (219 aa)
TBC1D15TBC1 domain family member 15. (673 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (855 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
LOC100723477Uncharacterized protein. (456 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa)
TAX1BP1Tax1 binding protein 1. (806 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SP1Sp1 transcription factor. (786 aa)
Atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
NBR1NBR1 autophagy cargo receptor. (993 aa)
NPAS1Neuronal PAS domain protein 1. (545 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
RRAS2RAS related 2. (168 aa)
SPENSpen family transcriptional repressor. (3456 aa)
USP31Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1141 aa)
FUNDC1FUN14 domain containing 1. (155 aa)
STK35Serine/threonine kinase 35. (539 aa)
USP43Ubiquitin specific peptidase 43; Belongs to the peptidase C19 family. (1016 aa)
BNIP3LBCL2 interacting protein 3 like. (214 aa)
SQSTM1Sequestosome 1. (415 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MFN1Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (737 aa)
RAB7BRAB7B, member RAS oncogene family. (196 aa)
ENSCPOP00000025880Miro domain-containing protein. (121 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
TFEBTranscription factor EB. (468 aa)
E2F1E2F transcription factor 1. (389 aa)
CFAP70Cilia and flagella associated protein 70. (1129 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
Ly6g5bUncharacterized protein. (195 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
RRASRAS related. (218 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (288 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
ENSCPOP00000030352Uncharacterized protein. (97 aa)
AGFG1ArfGAP with FG repeats 1. (586 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (572 aa)
RHOT1Ras homolog family member T1. (752 aa)
BECN1Beclin 1. (448 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
UbcUncharacterized protein. (159 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
BCL2L1BCL2 like 1. (233 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (942 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
BCL2L13BCL2 like 13. (461 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (338 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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