STRINGSTRING
ENSCPOP00000032088 ENSCPOP00000032088 MAPK8 MAPK8 PPP2CA PPP2CA ATG4A ATG4A MAPK3 MAPK3 RPS6KB2 RPS6KB2 Hmgb1 Hmgb1 ATG7 ATG7 TP53INP2 TP53INP2 SQSTM1 SQSTM1 STK35 STK35 TP53INP1 TP53INP1 RAB39B RAB39B Kiaa1671 Kiaa1671 DDIT4L DDIT4L ATG12 ATG12 RAB1A RAB1A RRAS2 RRAS2 RAB33B RAB33B DAPK2 DAPK2 H0WDU3_CAVPO H0WDU3_CAVPO NPAS1 NPAS1 ATG16L2 ATG16L2 H0WAS6_CAVPO H0WAS6_CAVPO TSSK6 TSSK6 Atg9a Atg9a AKT1S1 AKT1S1 PTEN PTEN RRAD RRAD REM2 REM2 H0W276_CAVPO H0W276_CAVPO LOC100721187 LOC100721187 IFITM10 IFITM10 Tssk2 Tssk2 BCL2 BCL2 RB1CC1 RB1CC1 Phf23 Phf23 RAB43 RAB43 H0W027_CAVPO H0W027_CAVPO LAMP1 LAMP1 RRAGA RRAGA HIF3A HIF3A ZFYVE28 ZFYVE28 MAP2K2 MAP2K2 AKT3 AKT3 ATG101 ATG101 LMLN LMLN TTC14 TTC14 TANK TANK RPS6KB1 RPS6KB1 VMP1 VMP1 WIPI1 WIPI1 ATG5 ATG5 ZFYVE1 ZFYVE1 DUS2 DUS2 EIF2AK3 EIF2AK3 DEPTOR DEPTOR MAPK1 MAPK1 PIK3CD PIK3CD CRYBB3 CRYBB3 PDIK1L PDIK1L MTOR MTOR RRAGB RRAGB TSSK4 TSSK4 TBK1 TBK1 Igbp1 Igbp1 RASL11B RASL11B KRAS KRAS NRAS NRAS MTMR14 MTMR14 ATG4D ATG4D UVRAG UVRAG ULK2 ULK2 PRKAA2 PRKAA2 GEM GEM C9orf72 C9orf72 SMCR8 SMCR8 RIT2 RIT2 CTSV CTSV CTSB CTSB ATG2A ATG2A SNAP47 SNAP47 Ctsd Ctsd PIK3R1 PIK3R1 IRS4 IRS4 RRAGC RRAGC HMGB4 HMGB4 PIK3R4 PIK3R4 TSSK3 TSSK3 NPAS3 NPAS3 CFLAR CFLAR RAB33A RAB33A ATG4B ATG4B ERN1 ERN1 PIK3CB PIK3CB DAPK1 DAPK1 ATG14 ATG14 KCNK1 KCNK1 WDR41 WDR41 RAF1 RAF1 VAMP8 VAMP8 ATG4C ATG4C RUBCN RUBCN MLST8 MLST8 MTMR3 MTMR3 PPP1R14B PPP1R14B RHEBL1 RHEBL1 MAP2K1 MAP2K1 SNAP29 SNAP29 TSC2 TSC2 MTMR4 MTMR4 TRAF6 TRAF6 SUPT20H SUPT20H TSC1 TSC1 ATG9B ATG9B PIK3C3 PIK3C3 RRAGD RRAGD HMGB2 HMGB2 PDPK1 PDPK1 EIF2AK4 EIF2AK4 PRKCQ PRKCQ EIF2S1 EIF2S1 INS INS ATG10 ATG10 DDIT4 DDIT4 GABARAPL2 GABARAPL2 ATG16L1 ATG16L1 ULK1 ULK1 RRAS RRAS ENSCPOP00000028708 ENSCPOP00000028708 AMBRA1 AMBRA1 ATG13 ATG13 LOC100713599 LOC100713599 RAB39A RAB39A NOL4 NOL4 RAB19 RAB19 BNIP3 BNIP3 LAMP2 LAMP2 LOC100734206 LOC100734206 ENSCPOP00000030352 ENSCPOP00000030352 RHEB RHEB ITPR1 ITPR1 NRBF2 NRBF2 DAPK3 DAPK3 AKT2 AKT2 BECN1 BECN1 CAMKK2 CAMKK2 RPTOR RPTOR REM1 REM1 RAB8A RAB8A CSDE1 CSDE1 MAPK9 MAPK9 NOL4L NOL4L STX17 STX17 SH3GLB1 SH3GLB1 HRAS HRAS RAB7A RAB7A Prkaca Prkaca MAPK10 MAPK10 BCL2L1 BCL2L1 RUBCNL RUBCNL GABARAPL1 GABARAPL1 PIK3CA PIK3CA ATG3 ATG3 ERN2 ERN2 Bad Bad ATG2B ATG2B PRKAA1 PRKAA1 IRS1 IRS1 IGF1R IGF1R HIF1A HIF1A Crygn Crygn PPP2CB PPP2CB RASEF RASEF RIT1 RIT1 WIPI2 WIPI2 PRKACB PRKACB AKT1 AKT1 PRKCD PRKCD MRAS MRAS RAB7B RAB7B STK11 STK11 MAP3K7 MAP3K7 HMGB3 HMGB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000032088Uncharacterized protein. (191 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
Hmgb1annotation not available (215 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (222 aa)
SQSTM1Sequestosome 1. (415 aa)
STK35Serine/threonine kinase 35. (539 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
Kiaa1671Tankyrase_bdg_C domain-containing protein. (386 aa)
DDIT4LDNA damage inducible transcript 4 like. (181 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
RAB1ARAB1A, member RAS oncogene family. (205 aa)
RRAS2RAS related 2. (168 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (483 aa)
H0WDU3_CAVPOUncharacterized protein. (147 aa)
NPAS1Neuronal PAS domain protein 1. (545 aa)
ATG16L2Autophagy related 16 like 2. (623 aa)
H0WAS6_CAVPOUncharacterized protein. (214 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
Atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
AKT1S1AKT1 substrate 1. (282 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (338 aa)
H0W276_CAVPOProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
LOC100721187Uncharacterized protein. (489 aa)
IFITM10Interferon induced transmembrane protein 10. (201 aa)
Tssk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (355 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
RB1CC1RB1 inducible coiled-coil 1. (1431 aa)
Phf23Uncharacterized protein. (56 aa)
RAB43RAB43, member RAS oncogene family. (210 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
LAMP1Lysosomal associated membrane protein 1. (410 aa)
RRAGARas related GTP binding A. (313 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (667 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (882 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
ATG101Autophagy related 101. (218 aa)
LMLNLeishmanolysin-like peptidase. (668 aa)
TTC14Tetratricopeptide repeat domain 14. (771 aa)
TANKTRAF family member associated NFKB activator. (419 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
VMP1Vacuole membrane protein 1. (406 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (777 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1112 aa)
DEPTORDEP domain containing MTOR interacting protein. (403 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CRYBB3BetaB3-crystallin; Belongs to the beta/gamma-crystallin family. (211 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (418 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
RRAGBRas related GTP binding B. (362 aa)
TSSK4Testis specific serine kinase 4. (296 aa)
TBK1TANK binding kinase 1. (729 aa)
Igbp1Uncharacterized protein. (339 aa)
RASL11BRAS like family 11 member B. (234 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
MTMR14Myotubularin related protein 14. (649 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
UVRAGUV radiation resistance associated. (698 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1033 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
RIT2Ras like without CAAX 2. (216 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (340 aa)
ATG2AAutophagy related 2A. (1904 aa)
SNAP47Synaptosome associated protein 47. (418 aa)
CtsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (407 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRS4Insulin receptor substrate 4. (1217 aa)
RRAGCRas related GTP binding C. (399 aa)
HMGB4High mobility group box 4. (184 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1354 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
NPAS3Neuronal PAS domain protein 3. (769 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
RAB33ARAB33A, member RAS oncogene family. (237 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (395 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
ATG14Autophagy related 14. (492 aa)
KCNK1Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa)
WDR41WD repeat domain 41. (462 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (460 aa)
RUBCNRubicon autophagy regulator. (954 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
MTMR3Myotubularin related protein 3. (1221 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (108 aa)
RHEBL1RHEB like 1. (183 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SNAP29Synaptosome associated protein 29. (255 aa)
TSC2TSC complex subunit 2. (1745 aa)
MTMR4Myotubularin related protein 4. (1189 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
SUPT20HSPT20 homolog, SAGA complex component. (781 aa)
TSC1TSC complex subunit 1. (1166 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (855 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
RRAGDRas related GTP binding D. (348 aa)
HMGB2High mobility group box 2. (211 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ATG10Autophagy related 10. (213 aa)
DDIT4DNA damage inducible transcript 4. (228 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
RRASRAS related. (218 aa)
ENSCPOP00000028708Uncharacterized protein. (153 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
LOC100713599Uncharacterized protein. (146 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
NOL4Nucleolar protein 4. (638 aa)
RAB19RAB19, member RAS oncogene family. (217 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
LAMP2Lysosomal associated membrane protein 2. (408 aa)
LOC100734206Uncharacterized protein. (461 aa)
ENSCPOP00000030352Uncharacterized protein. (97 aa)
RHEBUncharacterized protein. (184 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
NRBF2Nuclear receptor binding factor 2. (286 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BECN1Beclin 1. (448 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (565 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOL4LNucleolar protein 4 like. (573 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (301 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
BCL2L1BCL2 like 1. (233 aa)
RUBCNLRubicon like autophagy enhancer. (671 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ATG3Autophagy-related protein 3. (317 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (902 aa)
BadUncharacterized protein. (166 aa)
ATG2BAutophagy related 2B. (2081 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
CrygnGammaN-crystallin; Belongs to the beta/gamma-crystallin family. (183 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
RASEFRAS and EF-hand domain containing. (589 aa)
RIT1Ras like without CAAX 1. (219 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (443 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
RAB7BRAB7B, member RAS oncogene family. (196 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
HMGB3High mobility group box 3. (202 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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