STRINGSTRING
PCK1 PCK1 PFKFB1 PFKFB1 GYS1 GYS1 GAREM2 GAREM2 CAB39 CAB39 IGF1 IGF1 LOC100718700 LOC100718700 EIF4EBP1 EIF4EBP1 RAB8A RAB8A RPTOR RPTOR CAMKK2 CAMKK2 AKT2 AKT2 RAB10 RAB10 ADRA1A ADRA1A RAB2B RAB2B PPP2R2C PPP2R2C CREB3L4 CREB3L4 RHEB RHEB RAB2A RAB2A LOC100734206 LOC100734206 ENSCPOP00000030085 ENSCPOP00000030085 LOC100727637 LOC100727637 RAB14 RAB14 G6PC2 G6PC2 PRKAB2 PRKAB2 LEP LEP ENSCPOP00000028708 ENSCPOP00000028708 ULK1 ULK1 INS INS ADIPOQ ADIPOQ CCND1 CCND1 PFKFB3 PFKFB3 CPT1A CPT1A AKT1 AKT1 STK11 STK11 CD36 CD36 TBC1D1 TBC1D1 MAP3K7 MAP3K7 PPP2R5E PPP2R5E PPP2R1B PPP2R1B PPP2CA PPP2CA SLC2A4 SLC2A4 RPS6KB2 RPS6KB2 PPP2R5A PPP2R5A PPP2R2D PPP2R2D PFKFB2 PFKFB2 LIPE LIPE PPARGC1A PPARGC1A RAB11B RAB11B STRADA STRADA CCNA1 CCNA1 CREB1 CREB1 PFKL PFKL AKT1S1 AKT1S1 Foxo3 Foxo3 PRKAG3 PRKAG3 H0W160_CAVPO H0W160_CAVPO H0W027_CAVPO H0W027_CAVPO PPP2R5B PPP2R5B PPP2R2A PPP2R2A EEF2 EEF2 PRKAG2 PRKAG2 Prkab1 Prkab1 AKT3 AKT3 CPT1C CPT1C LEPR LEPR RPS6KB1 RPS6KB1 GYS2 GYS2 CREB5 CREB5 G6PC G6PC STRADB STRADB INSR INSR PIK3CD PIK3CD CRTC2 CRTC2 CFTR CFTR EEF2K EEF2K ELAVL1 ELAVL1 LOC100719661 LOC100719661 MTOR MTOR PPP2R5D PPP2R5D PCK2 PCK2 CCNA2 CCNA2 CREB3L3 CREB3L3 CREB3L1 CREB3L1 PRKAA2 PRKAA2 CREB3L2 CREB3L2 H0VCZ7_CAVPO H0VCZ7_CAVPO LOC100734047 LOC100734047 PFKM PFKM PIK3R1 PIK3R1 IRS4 IRS4 CPT1B CPT1B FBP2 FBP2 HNF4A HNF4A PIK3CA PIK3CA ACACA ACACA NOSTRIN NOSTRIN PRKAA1 PRKAA1 IRS1 IRS1 IGF1R IGF1R ADIPOR2 ADIPOR2 PPP2CB PPP2CB PPP2R3C PPP2R3C ACACB ACACB TSC1 TSC1 HMGCR HMGCR PFKFB4 PFKFB4 CAB39L CAB39L PDPK1 PDPK1 PPP2R2B PPP2R2B SCD5 SCD5 TSC2 TSC2 RHEBL1 RHEBL1 PRKAG1 PRKAG1 G6PC3 G6PC3 PPP2R3A PPP2R3A SREBF1 SREBF1 FASN FASN PPARG PPARG PFKP PFKP MLYCD MLYCD PIK3CB PIK3CB SIRT1 SIRT1 ADIPOR1 ADIPOR1 CREB3 CREB3 PPP2R5C PPP2R5C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (736 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (746 aa)
CAB39Calcium binding protein 39. (341 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
LOC100718700Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (358 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (565 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RAB10RAB10, member RAS oncogene family. (211 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
RAB2BRAB2B, member RAS oncogene family. (216 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (461 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
RHEBUncharacterized protein. (184 aa)
RAB2ARAB2A, member RAS oncogene family. (172 aa)
LOC100734206Uncharacterized protein. (461 aa)
ENSCPOP00000030085AMPKBI domain-containing protein. (256 aa)
LOC100727637Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (358 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
ENSCPOP00000028708Uncharacterized protein. (153 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (549 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
TBC1D1TBC1 domain family member 1. (1254 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (556 aa)
LIPELipase E, hormone sensitive type. (802 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
STRADASTE20 related adaptor alpha. (431 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
AKT1S1AKT1 substrate 1. (282 aa)
Foxo3Forkhead box O3. (660 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (465 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
EEF2Eukaryotic translation elongation factor 2. (815 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
Prkab1AMPKBI domain-containing protein. (270 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (807 aa)
LEPRLeptin receptor. (1174 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (633 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
STRADBSTE20 related adaptor beta. (416 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CRTC2CREB regulated transcription coactivator 2. (692 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1448 aa)
EEF2KEukaryotic elongation factor 2 kinase. (724 aa)
ELAVL1ELAV like RNA binding protein 1. (295 aa)
LOC100719661Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (395 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (594 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (652 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
LOC100734047Uncharacterized protein. (567 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRS4Insulin receptor substrate 4. (1217 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ACACAAcetyl-CoA carboxylase alpha. (2393 aa)
NOSTRINNitric oxide synthase trafficking. (471 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
TSC1TSC complex subunit 1. (1166 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (315 aa)
TSC2TSC complex subunit 2. (1745 aa)
RHEBL1RHEB like 1. (183 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1122 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1155 aa)
FASNFatty acid synthase. (2530 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (792 aa)
MLYCDMalonyl-CoA decarboxylase. (488 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
SIRT1Sirtuin 1. (717 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (589 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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