STRINGSTRING
ADCY9 ADCY9 AKT1 AKT1 CLPB CLPB HSPA2 HSPA2 FOXA2 FOXA2 PRKACB PRKACB INS INS ADCY6 ADCY6 ADCY7 ADCY7 PRKAB2 PRKAB2 CRYAB CRYAB ENSCPOP00000030021 ENSCPOP00000030021 ENSCPOP00000030085 ENSCPOP00000030085 HSPA1L HSPA1L NRAS NRAS KRAS KRAS ADCY2 ADCY2 MTOR MTOR CAT CAT LOC100734206 LOC100734206 HSPA6 HSPA6 AKT2 AKT2 RPTOR RPTOR PIK3CD PIK3CD EIF4EBP2 EIF4EBP2 Prkaca Prkaca HRAS HRAS IGF1 IGF1 CSDE1 CSDE1 INSR INSR ADCY5 ADCY5 ATG5 ATG5 SOD1 SOD1 HDAC2 HDAC2 ADCY4 ADCY4 RPS6KB2 RPS6KB2 RPS6KB1 RPS6KB1 AKT3 AKT3 Prkab1 Prkab1 PRKAG2 PRKAG2 H0W027_CAVPO H0W027_CAVPO PRKAG3 PRKAG3 Foxo3 Foxo3 AKT1S1 AKT1S1 LOC100717205 LOC100717205 TIMM8B TIMM8B SOD3 SOD3 SOD2 SOD2 Timm8a Timm8a LOC100713242 LOC100713242 SIRT1 SIRT1 PIK3CB PIK3CB KCNK1 KCNK1 ADCY1 ADCY1 PRKAG1 PRKAG1 HSPA8 HSPA8 IGF1R IGF1R IRS1 IRS1 PRKAA1 PRKAA1 PTRHD1 PTRHD1 ADCY3 ADCY3 PIK3CA PIK3CA ADCY8 ADCY8 IRS4 IRS4 HDAC1 HDAC1 PIK3R1 PIK3R1 H0VCZ7_CAVPO H0VCZ7_CAVPO PRKAA2 PRKAA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (705 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (620 aa)
FOXA2Forkhead box A2. (459 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CRYABAlphaB-crystallin; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
ENSCPOP00000030021Uncharacterized protein; Belongs to the heat shock protein 70 family. (537 aa)
ENSCPOP00000030085AMPKBI domain-containing protein. (256 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (642 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (527 aa)
LOC100734206Uncharacterized protein. (461 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (121 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
Prkab1AMPKBI domain-containing protein. (270 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (465 aa)
Foxo3Forkhead box O3. (660 aa)
AKT1S1AKT1 substrate 1. (282 aa)
LOC100717205Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (83 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (246 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
Timm8azf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
LOC100713242zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
SIRT1Sirtuin 1. (717 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
KCNK1Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa)
ADCY1Adenylate cyclase 1. (944 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
IRS4Insulin receptor substrate 4. (1217 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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