(50 nodes) Ferroptosis network (Cavia porcellus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ACSL4	Acyl-CoA synthetase long chain family member 4. (707 aa)
	PELP1	Proline, glutamate and leucine rich protein 1. (1138 aa)
	PCBP2	Poly(rC) binding protein 2. (362 aa)
	CYBB	Cytochrome b-245 beta chain. (570 aa)
	Acsl1	Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family. (698 aa)
	PCBP3	Poly(rC) binding protein 3. (370 aa)
	SLC39A8	Solute carrier family 39 member 8. (397 aa)
	GSS	Glutathione synthetase. (474 aa)
	ACSL5	AMP-binding domain-containing protein. (682 aa)
	LOC100717203	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (639 aa)
	VDAC3	Voltage dependent anion channel 3. (283 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (712 aa)
	TFR2	Transferrin receptor 2. (788 aa)
	NCOA4	Nuclear receptor coactivator 4. (621 aa)
	H0VM53_CAVPO	AMP-binding domain-containing protein. (696 aa)
	SLC7A11	Solute carrier family 7 member 11. (507 aa)
	SLC3A2	Solute carrier family 3 member 2. (555 aa)
	PCBP1	Poly(rC) binding protein 1. (356 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	PCBP4	Poly(rC) binding protein 4. (403 aa)
	FTMT	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (229 aa)
	H0VYL3_CAVPO	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (158 aa)
	MELTF	Melanotransferrin; Belongs to the transferrin family. (755 aa)
	H0W943_CAVPO	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (173 aa)
	HMOX1	Heme oxygenase 1. (297 aa)
	SAT2	Spermidine/spermine N1-acetyltransferase family member 2. (170 aa)
	MAP1LC3A	Microtubule associated protein 1 light chain 3 alpha. (121 aa)
	XKRX	XK-related protein. (449 aa)
	CP	Ceruloplasmin; Belongs to the multicopper oxidase family. (1097 aa)
	ENSCPOP00000023290	annotation not available (175 aa)
	PGPEP1	Pyroglutamyl-peptidase I. (209 aa)
	ENSCPOP00000023381	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (160 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
	Map1lc3b	Uncharacterized protein. (126 aa)
	LOC100721922	Uncharacterized protein; Belongs to the transferrin family. (700 aa)
	ENSCPOP00000024451	Uncharacterized protein. (153 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
	VDAC2	Voltage dependent anion channel 2. (294 aa)
	TFRC	Transferrin receptor protein 1. (765 aa)
	SLC11A2	Solute carrier family 11 member 2. (568 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (182 aa)
	SLC39A14	Solute carrier family 39 member 14. (489 aa)
	Gpx4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
	SAT1	Spermidine/spermine N1-acetyltransferase 1. (171 aa)
	PRNP	Major prion protein; Belongs to the prion family. (244 aa)
	SLC40A1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (486 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	STEAP3	STEAP3 metalloreductase. (522 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL3	ACSL4	ENSCPOP00000031616	ENSCPOP00000001398	Acyl-CoA synthetase long chain family member 3.	Acyl-CoA synthetase long chain family member 4.	0.836
ACSL3	ACSL5	ENSCPOP00000031616	ENSCPOP00000005545	Acyl-CoA synthetase long chain family member 3.	AMP-binding domain-containing protein.	0.862
ACSL3	Acsl1	ENSCPOP00000031616	ENSCPOP00000002484	Acyl-CoA synthetase long chain family member 3.	Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family.	0.898
ACSL3	H0VM53_CAVPO	ENSCPOP00000031616	ENSCPOP00000011471	Acyl-CoA synthetase long chain family member 3.	AMP-binding domain-containing protein.	0.834
ACSL3	TP53	ENSCPOP00000031616	ENSCPOP00000029751	Acyl-CoA synthetase long chain family member 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.697
ACSL4	ACSL3	ENSCPOP00000001398	ENSCPOP00000031616	Acyl-CoA synthetase long chain family member 4.	Acyl-CoA synthetase long chain family member 3.	0.836
ACSL4	ACSL5	ENSCPOP00000001398	ENSCPOP00000005545	Acyl-CoA synthetase long chain family member 4.	AMP-binding domain-containing protein.	0.939
ACSL4	Acsl1	ENSCPOP00000001398	ENSCPOP00000002484	Acyl-CoA synthetase long chain family member 4.	Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family.	0.949
ACSL4	Gpx4	ENSCPOP00000001398	ENSCPOP00000029229	Acyl-CoA synthetase long chain family member 4.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.436
ACSL4	H0VM53_CAVPO	ENSCPOP00000001398	ENSCPOP00000011471	Acyl-CoA synthetase long chain family member 4.	AMP-binding domain-containing protein.	0.837
ACSL4	LPCAT3	ENSCPOP00000001398	ENSCPOP00000025015	Acyl-CoA synthetase long chain family member 4.	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family.	0.553
ACSL4	TFRC	ENSCPOP00000001398	ENSCPOP00000026959	Acyl-CoA synthetase long chain family member 4.	Transferrin receptor protein 1.	0.447
ACSL4	TP53	ENSCPOP00000001398	ENSCPOP00000029751	Acyl-CoA synthetase long chain family member 4.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.706
ACSL5	ACSL3	ENSCPOP00000005545	ENSCPOP00000031616	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 3.	0.862
ACSL5	ACSL4	ENSCPOP00000005545	ENSCPOP00000001398	AMP-binding domain-containing protein.	Acyl-CoA synthetase long chain family member 4.	0.939
ACSL5	Acsl1	ENSCPOP00000005545	ENSCPOP00000002484	AMP-binding domain-containing protein.	Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family.	0.928
ACSL5	H0VM53_CAVPO	ENSCPOP00000005545	ENSCPOP00000011471	AMP-binding domain-containing protein.	AMP-binding domain-containing protein.	0.818
ACSL5	TP53	ENSCPOP00000005545	ENSCPOP00000029751	AMP-binding domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.828
ATG5	ATG7	ENSCPOP00000012668	ENSCPOP00000023655	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.993
ATG5	MAP1LC3A	ENSCPOP00000012668	ENSCPOP00000022836	Autophagy protein 5; Involved in autophagic vesicle formation.	Microtubule associated protein 1 light chain 3 alpha.	0.933