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| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa) |
| | KCNK1 | Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (481 aa) |
| | PRICKLE2 | Prickle planar cell polarity protein 2. (901 aa) |
| | GPC4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (547 aa) |
| | APC | APC regulator of WNT signaling pathway. (2842 aa) |
| | WIF1 | WNT inhibitory factor 1. (381 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | EFEMP1 | EGF containing fibulin extracellular matrix protein 1. (454 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1666 aa) |
| | Rnf43 | RING-type domain-containing protein. (636 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa) |
| | ELP3 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (561 aa) |
| | AXIN2 | Axin 2. (802 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (928 aa) |
| | CCN6 | Cellular communication network factor 6. (349 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | TBL1XR1 | Transducin beta like 1 X-linked receptor 1. (504 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa) |
| | C17orf64 | Chromosome 17 open reading frame 64. (220 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (832 aa) |
| | LOC100727500 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa) |
| | Csnk2a1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | RYK | Receptor like tyrosine kinase. (532 aa) |
| | CHD2 | Uncharacterized protein. (1689 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (698 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (531 aa) |
| | Tbl1x | Uncharacterized protein. (526 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1600 aa) |
| | SENP1 | SUMO specific peptidase 1. (638 aa) |
| | INVS | Inversin. (1058 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (349 aa) |
| | TES | Testin LIM domain protein. (417 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | RSPO4 | R-spondin 4. (233 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (518 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (758 aa) |
| | WDR92 | WD repeat domain 92. (357 aa) |
| | VANGL2 | Vang-like protein. (548 aa) |
| | SFRP4 | Secreted frizzled related protein 4. (347 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (244 aa) |
| | AXIN1 | Axin 1. (863 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (440 aa) |
| | CER1 | Cerberus 1, DAN family BMP antagonist. (270 aa) |
| | PKP4 | Plakophilin 4. (1195 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (500 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (916 aa) |
| | CHD7 | Chromodomain helicase DNA binding protein 7. (2996 aa) |
| | ZNRF3 | Zinc and ring finger 3. (919 aa) |
| | LRRC45 | Leucine rich repeat containing 45. (669 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (901 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (587 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa) |
| | FRZB | Frizzled related protein. (325 aa) |
| | LRRC24 | Leucine rich repeat containing 24. (508 aa) |
| | CHD6 | Chromodomain helicase DNA binding protein 6. (2716 aa) |
| | H0VV76_CAVPO | Protein kinase domain-containing protein. (196 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (211 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | DKK1 | Dickkopf WNT signaling pathway inhibitor 1. (229 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa) |
| | AMIGO3 | Adhesion molecule with Ig like domain 3. (502 aa) |
| | Prickle4 | Uncharacterized protein. (316 aa) |
| | CTNND2 | Catenin delta 2. (1098 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (659 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (218 aa) |
| | Ccnd2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa) |
| | GPC2 | Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (572 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (737 aa) |
| | ARSI | Arylsulfatase family member I. (572 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (769 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2086 aa) |
| | SFRP5 | Secreted frizzled related protein 5. (296 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (188 aa) |
| | TCF7 | Transcription factor 7. (262 aa) |
| | SENP2 | SUMO specific peptidase 2. (589 aa) |
| | PRICKLE3 | Prickle planar cell polarity protein 3. (514 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa) |
| | DAAM1 | Dishevelled associated activator of morphogenesis 1. (1077 aa) |
| | CSNK1A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (211 aa) |
| | LGR6 | Leucine rich repeat containing G protein-coupled receptor 6. (966 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (350 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (717 aa) |
| | ENSCPOP00000022942 | Uncharacterized protein. (168 aa) |
| | CAMK2G | Calcium/calmodulin dependent protein kinase II gamma. (545 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (275 aa) |
| | CBY1 | Chibby family member 1, beta catenin antagonist. (127 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1060 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (396 aa) |
| | CCN4 | Cellular communication network factor 4. (367 aa) |
| | EFEMP2 | EGF containing fibulin extracellular matrix protein 2. (443 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (327 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | CTNNBIP1 | Catenin beta interacting protein 1. (81 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa) |
| | SERPINF1 | SERPIN domain-containing protein; Belongs to the serpin family. (418 aa) |
| | CXXC5 | CXXC finger protein 5. (317 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | GPC6 | Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (565 aa) |
| | SOX7 | SRY-box transcription factor 7. (384 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | ROR1 | Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (931 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (798 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | ENSCPOP00000026288 | Uncharacterized protein. (201 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa) |
| | RSPO2 | R-spondin 2. (243 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | Cacybp | Uncharacterized protein. (230 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (307 aa) |
| | LGR5 | Leucine rich repeat containing G protein-coupled receptor 5. (882 aa) |
| | NKD2 | NKD inhibitor of WNT signaling pathway 2. (440 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (189 aa) |
| | Ly6g5b | Uncharacterized protein. (195 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | SOX18 | SRY-box transcription factor 18. (375 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa) |
| | FHDC1 | FH2 domain containing 1. (1055 aa) |
| | PORCN | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | ENSCPOP00000029251 | Uncharacterized protein; Belongs to the SKP1 family. (147 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) |
| | SNAPIN | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa) |
| | VANGL1 | Vang-like protein. (522 aa) |
| | CHD9 | Chromodomain helicase DNA binding protein 9. (2804 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (505 aa) |
| | SOST | Sclerostin. (202 aa) |
| | Camk2d | Protein kinase domain-containing protein. (532 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (663 aa) |
| | AMIGO1 | Adhesion molecule with Ig like domain 1. (492 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (467 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (530 aa) |
| | RSPO1 | R-spondin 1. (266 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | RSPO3 | R-spondin 3. (239 aa) |
| | ROR2 | Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | CREBBP | CREB binding protein. (2441 aa) |
| | PPP3R1 | Uncharacterized protein. (169 aa) |
| | DAAM2 | Dishevelled associated activator of morphogenesis 2. (1083 aa) |
| | CTBP2 | C-terminal binding protein 2. (978 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa) |
| | BAMBI | BMP and activin membrane bound inhibitor. (234 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | Prkaca | Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | MAPK10 | Mitogen-activated protein kinase 10. (434 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | SOX17 | SRY-box transcription factor 17. (400 aa) |
