STRINGSTRING
SMURF1 SMURF1 DHH DHH PTCH1 PTCH1 KIF27 KIF27 LMBR1L LMBR1L LMBR1 LMBR1 GLI1 GLI1 CDON CDON BTRC BTRC LOC100727500 LOC100727500 CUL3 CUL3 SPOPL SPOPL ATRN ATRN CSNK1G3 CSNK1G3 EVC2 EVC2 EVC EVC GRK3 GRK3 CSNK1D CSNK1D KIF3A KIF3A PTCH2 PTCH2 MEGF8 MEGF8 SMO SMO GSK3B GSK3B LOC106028822 LOC106028822 KIF7 KIF7 MGRN1 MGRN1 H0VV76_CAVPO H0VV76_CAVPO BOC BOC CUL1 CUL1 BCL2 BCL2 Ccnd2 Ccnd2 H0W3X9_CAVPO H0W3X9_CAVPO CSNK1G2 CSNK1G2 CSNK1A1 CSNK1A1 MOSMO MOSMO ENSCPOP00000024297 ENSCPOP00000024297 GLI2 GLI2 SMURF2 SMURF2 ARRB1 ARRB1 GLI3 GLI3 PRKACB PRKACB CCND1 CCND1 CSNK1G1 CSNK1G1 GKAP1 GKAP1 SUFU SUFU SPOP SPOP GPR161 GPR161 LRP4 LRP4 ENSCPOP00000030527 ENSCPOP00000030527 IHH IHH SHH SHH FBXW11 FBXW11 HHIP HHIP GRK2 GRK2 ARRB2 ARRB2 Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (757 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
PTCH1Patched 1. (1379 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1363 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (488 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
GLI1GLI family zinc finger 1. (1104 aa)
CDONCell adhesion associated, oncogene regulated. (1265 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
LOC100727500Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
CUL3Cullin 3; Belongs to the cullin family. (765 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
ATRNAttractin. (1425 aa)
CSNK1G3Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (448 aa)
EVC2EvC ciliary complex subunit 2. (1198 aa)
EVCEvC ciliary complex subunit 1. (985 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
PTCH2Patched 2. (1207 aa)
MEGF8Multiple EGF like domains 8. (2787 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
LOC106028822Uncharacterized protein. (399 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1336 aa)
MGRN1Mahogunin ring finger 1. (578 aa)
H0VV76_CAVPOProtein kinase domain-containing protein. (196 aa)
BOCBOC cell adhesion associated, oncogene regulated. (1106 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (436 aa)
CSNK1A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
MOSMOModulator of smoothened. (167 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
GLI2GLI family zinc finger 2. (1570 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
ARRB1Arrestin beta 1. (430 aa)
GLI3GLI family zinc finger 3. (1580 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (459 aa)
GKAP1G kinase anchoring protein 1. (364 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (548 aa)
LRP4LDL receptor related protein 4. (1951 aa)
ENSCPOP00000030527Uncharacterized protein. (111 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
FBXW11F-box and WD repeat domain containing 11. (530 aa)
HHIPHedgehog interacting protein. (699 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
ARRB2Arrestin beta 2. (417 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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