STRINGSTRING
Golga2 Golga2 LIMK2 LIMK2 FCGR2 FCGR2 MAP2K1 MAP2K1 PRKCB PRKCB ARPC3 ARPC3 WASF1 WASF1 PIP5K1B PIP5K1B SCIN SCIN H0V789_CAVPO H0V789_CAVPO PLD2 PLD2 PLA2G4D PLA2G4D PLA2G4F PLA2G4F AMPH AMPH PIK3CA PIK3CA CRK CRK PIK3R1 PIK3R1 ARF6 ARF6 GSN GSN Plpp1 Plpp1 WASF3 WASF3 VASP VASP BOLA1 BOLA1 SYK SYK PLD1 PLD1 ASAP1 ASAP1 LYN LYN SPHK1 SPHK1 GAB2 GAB2 PIK3CD PIK3CD MAPK1 MAPK1 PLA2G4E PLA2G4E H0VR18_CAVPO H0VR18_CAVPO RPS6KB1 RPS6KB1 PRKCA PRKCA LOC106024982 LOC106024982 DOCK1 DOCK1 AKT3 AKT3 PRKCE PRKCE RAC2 RAC2 CCDC125 CCDC125 PLCG1 PLCG1 ASAP3 ASAP3 H0VZI8_CAVPO H0VZI8_CAVPO H0W027_CAVPO H0W027_CAVPO WAS WAS PLPP2 PLPP2 LAT LAT H0W6K2_CAVPO H0W6K2_CAVPO BIN1 BIN1 H0WAH0_CAVPO H0WAH0_CAVPO H0WAR2_CAVPO H0WAR2_CAVPO Plpp3 Plpp3 ARPC4 ARPC4 ARPC1B ARPC1B H0WDE0_CAVPO H0WDE0_CAVPO PLA2G6 PLA2G6 ASAP2 ASAP2 ENSCPOP00000022167 ENSCPOP00000022167 RAC1 RAC1 ENSCPOP00000022622 ENSCPOP00000022622 ENSCPOP00000022635 ENSCPOP00000022635 PLA2G4A PLA2G4A ENSCPOP00000023578 ENSCPOP00000023578 ENSCPOP00000023636 ENSCPOP00000023636 WASF2 WASF2 VAV2 VAV2 ENSCPOP00000023778 ENSCPOP00000023778 RPS6KB2 RPS6KB2 ENSCPOP00000023913 ENSCPOP00000023913 MAPK3 MAPK3 H0VVB6_CAVPO H0VVB6_CAVPO PRKCG PRKCG ARPC5 ARPC5 ARPC5L ARPC5L ENSCPOP00000025410 ENSCPOP00000025410 SPHK2 SPHK2 ENSCPOP00000025793 ENSCPOP00000025793 ENSCPOP00000025800 ENSCPOP00000025800 INPPL1 INPPL1 PRKCD PRKCD AKT1 AKT1 ENSCPOP00000026228 ENSCPOP00000026228 DNM2 DNM2 ENSCPOP00000027199 ENSCPOP00000027199 MYO10 MYO10 CRKL CRKL MARCKSL1 MARCKSL1 PTPRC PTPRC ENSCPOP00000028990 ENSCPOP00000028990 ENSCPOP00000029145 ENSCPOP00000029145 ENSCPOP00000029468 ENSCPOP00000029468 INPP5D INPP5D CFL2 CFL2 ENSCPOP00000029769 ENSCPOP00000029769 ARPC2 ARPC2 LOC100734206 LOC100734206 ENSCPOP00000030754 ENSCPOP00000030754 ENSCPOP00000030758 ENSCPOP00000030758 ENSCPOP00000031130 ENSCPOP00000031130 ENSCPOP00000031332 ENSCPOP00000031332 AKT2 AKT2 CDC42 CDC42 ENSCPOP00000031748 ENSCPOP00000031748 Fcgr4 Fcgr4 ENSCPOP00000032517 ENSCPOP00000032517 RAF1 RAF1 ARPC1A ARPC1A PIP5K1C PIP5K1C PIP5K1A PIP5K1A PAK1 PAK1 NCF1 NCF1 VAV3 VAV3 LIMK1 LIMK1 PIK3CB PIK3CB PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Golga2Uncharacterized protein. (1026 aa)
LIMK2LIM domain kinase 2. (637 aa)
FCGR2Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
WASF1WASP family member 1. (559 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (488 aa)
SCINScinderin. (715 aa)
H0V789_CAVPOIg-like domain-containing protein. (126 aa)
PLD2Phospholipase. (936 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLA2G4FPhospholipase A2. (842 aa)
AMPHAmphiphysin. (680 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
GSNGelsolin. (775 aa)
Plpp1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these b [...] (284 aa)
WASF3WASP family member 3. (502 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (376 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (134 aa)
SYKTyrosine-protein kinase. (579 aa)
PLD1Phospholipase. (1064 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1147 aa)
LYNTyrosine-protein kinase. (512 aa)
SPHK1Sphingosine kinase 1. (386 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PLA2G4EPhospholipase A2. (805 aa)
H0VR18_CAVPOIg-like domain-containing protein. (136 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
LOC106024982Phospholipase A2. (795 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1865 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
CCDC125Coiled-coil domain containing 125. (543 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (901 aa)
H0VZI8_CAVPOIg-like domain-containing protein. (123 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
WASWASP actin nucleation promoting factor. (505 aa)
PLPP2Phospholipid phosphatase 2. (260 aa)
LATLinker for activation of T cells. (236 aa)
H0W6K2_CAVPOIg-like domain-containing protein. (135 aa)
BIN1Bridging integrator 1. (577 aa)
H0WAH0_CAVPOIg-like domain-containing protein. (121 aa)
H0WAR2_CAVPOIg-like domain-containing protein. (139 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (176 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
H0WDE0_CAVPOIg-like domain-containing protein. (118 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (988 aa)
ENSCPOP00000022167Ig-like domain-containing protein. (174 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
ENSCPOP00000022622Ig-like domain-containing protein. (129 aa)
ENSCPOP00000022635Uncharacterized protein. (311 aa)
PLA2G4APhospholipase A2. (749 aa)
ENSCPOP00000023578Ig-like domain-containing protein. (129 aa)
ENSCPOP00000023636Ig-like domain-containing protein. (129 aa)
WASF2WASP family member 2. (497 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
ENSCPOP00000023778Ig-like domain-containing protein. (179 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
ENSCPOP00000023913Ig-like domain-containing protein. (122 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
H0VVB6_CAVPOIg-like domain-containing protein. (137 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ENSCPOP00000025410Ig-like domain-containing protein. (118 aa)
SPHK2Sphingosine kinase 2. (655 aa)
ENSCPOP00000025793Ig-like domain-containing protein. (146 aa)
ENSCPOP00000025800Uncharacterized protein. (348 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1267 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSCPOP00000026228Ig-like domain-containing protein. (134 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (878 aa)
ENSCPOP00000027199Ig-like domain-containing protein. (128 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2051 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MARCKSL1MARCKS like 1. (238 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1307 aa)
ENSCPOP00000028990Ig-like domain-containing protein. (138 aa)
ENSCPOP00000029145Ig-like domain-containing protein. (136 aa)
ENSCPOP00000029468Ig-like domain-containing protein. (122 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1220 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSCPOP00000029769Ig-like domain-containing protein. (139 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
LOC100734206Uncharacterized protein. (461 aa)
ENSCPOP00000030754Ig-like domain-containing protein. (139 aa)
ENSCPOP00000030758Ig-like domain-containing protein. (122 aa)
ENSCPOP00000031130Ig-like domain-containing protein. (136 aa)
ENSCPOP00000031332Ig-like domain-containing protein. (138 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
ENSCPOP00000031748Ig-like domain-containing protein. (136 aa)
Fcgr4Low affinity immunoglobulin gamma Fc region receptor IV; Receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon (By similarity). Binds with intermediate affinity to both IgG2a and IgG2b (By similarity). Can bind to IgG2a and IgG2b monomers (By similarity). Does not display binding to IgG1 or IgG3 (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (By similarity). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (By similarity) [...] (250 aa)
ENSCPOP00000032517Ig-like domain-containing protein. (129 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (689 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (536 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NCF1Neutrophil cytosolic factor 1. (401 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
LIMK1LIM domain kinase 1. (646 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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