STRINGSTRING
GNG8 GNG8 Kcnj3 Kcnj3 Prkaca Prkaca CACNA1D CACNA1D ENSCPOP00000032059 ENSCPOP00000032059 ENSCPOP00000031664 ENSCPOP00000031664 ENSCPOP00000031524 ENSCPOP00000031524 LOC100732436 LOC100732436 GNGT2 GNGT2 Camk2d Camk2d ITPR1 ITPR1 ENSCPOP00000030509 ENSCPOP00000030509 GNAI1 GNAI1 PLCB2 PLCB2 GNG4 GNG4 C1orf226 C1orf226 PLCB4 PLCB4 RYR3 RYR3 CALM3 CALM3 ADCY7 ADCY7 RYR2 RYR2 ADCY6 ADCY6 GUCY1A2 GUCY1A2 GRIA2 GRIA2 GRIA4 GRIA4 GRIN2C GRIN2C CALM2 CALM2 CALM1 CALM1 ADCY1 ADCY1 PRKCB PRKCB GRIA3 GRIA3 H0V1A0_CAVPO H0V1A0_CAVPO GRIA1 GRIA1 ADCY10 ADCY10 H0V4J9_CAVPO H0V4J9_CAVPO GNB1 GNB1 PTRHD1 PTRHD1 ADCY3 ADCY3 ADCYAP1R1 ADCYAP1R1 GRIN2B GRIN2B CAMK2A CAMK2A ADCY8 ADCY8 GNGT1 GNGT1 NOS1AP NOS1AP H0VE70_CAVPO H0VE70_CAVPO MTNR1A MTNR1A GNG13 GNG13 KCNJ6 KCNJ6 MTNR1B MTNR1B ADCY2 ADCY2 GUCY1A1 GUCY1A1 GNAI3 GNAI3 CACNA1I CACNA1I H0VKV0_CAVPO H0VKV0_CAVPO CACNA1H CACNA1H MAPK1 MAPK1 PER1 PER1 GNB5 GNB5 GRIN2A GRIN2A ADCY5 ADCY5 CALML3 CALML3 ADCY4 ADCY4 PRKCA PRKCA GUCY1B1 GUCY1B1 PRKG2 PRKG2 RPS6KA5 RPS6KA5 ADCYAP1 ADCYAP1 RYR1 RYR1 GNB2 GNB2 H0VZ93_CAVPO H0VZ93_CAVPO CAMK2B CAMK2B GNB3 GNB3 ARSI ARSI ITPR3 ITPR3 LOC100718831 LOC100718831 H0WBW4_CAVPO H0WBW4_CAVPO CACNA1G CACNA1G KCNJ9 KCNJ9 CREB1 CREB1 PLCB3 PLCB3 LOC100732158 LOC100732158 FOS FOS GNG3 GNG3 CAMK2G CAMK2G GNG7 GNG7 CACNA1C CACNA1C RASD1 RASD1 PLCB1 PLCB1 CALML4 CALML4 PER2 PER2 MAPK3 MAPK3 PRKCG PRKCG GNG2 GNG2 GNAO1 GNAO1 GNG11 GNG11 GNB4 GNB4 GNAI2 GNAI2 PRKG1 PRKG1 ADCY9 ADCY9 GNG12 GNG12 GRIN1 GRIN1 Gng5 Gng5 PRKACB PRKACB GNAQ GNAQ KCNJ5 KCNJ5 GRIN2D GRIN2D
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
ENSCPOP00000031664Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (702 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
LOC100732436Uncharacterized protein. (327 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAI1Uncharacterized protein. (330 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
C1orf226Chromosome 1 open reading frame 226. (270 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
RYR3Ryanodine receptor 3. (4843 aa)
CALM3Calmodulin 3. (149 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
RYR2Ryanodine receptor 2. (4910 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (635 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
ADCY1Adenylate cyclase 1. (944 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
H0V1A0_CAVPOYccV-like domain-containing protein. (541 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
ADCY10Adenylate cyclase 10. (1581 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
GNB1Beta-transducin. (340 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (448 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GNG13G protein subunit gamma 13. (67 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (429 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PER1Period circadian regulator 1. (1286 aa)
GNB5G protein subunit beta 5. (406 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
PRKG2cGMP-dependent protein kinase. (758 aa)
RPS6KA5Ribosomal protein S6 kinase. (835 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (180 aa)
RYR1Ryanodine receptor 1. (4554 aa)
GNB2G protein subunit beta 2. (378 aa)
H0VZ93_CAVPOPAS domain-containing protein. (1009 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
GNB3G protein subunit beta 3. (340 aa)
ARSIArylsulfatase family member I. (572 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
LOC100718831YccV-like domain-containing protein. (514 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
LOC100732158Uncharacterized protein. (246 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
RASD1Ras related dexamethasone induced 1. (280 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CALML4Calmodulin like 4. (153 aa)
PER2Period circadian regulator 2. (1237 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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