STRINGSTRING
GRIK4 GRIK4 Prkaca Prkaca GRK2 GRK2 CACNA1D CACNA1D PPP3R1 PPP3R1 HOMER1 HOMER1 ENSCPOP00000031524 ENSCPOP00000031524 LOC100732436 LOC100732436 GNGT2 GNGT2 ENSCPOP00000030659 ENSCPOP00000030659 ITPR1 ITPR1 ENSCPOP00000030509 ENSCPOP00000030509 GNAI1 GNAI1 PLCB2 PLCB2 GNG4 GNG4 PLCB4 PLCB4 ENSCPOP00000028569 ENSCPOP00000028569 ADCY7 ADCY7 ADCY6 ADCY6 GNG8 GNG8 GRIN2D GRIN2D GNAQ GNAQ PRKACB PRKACB Gng5 Gng5 GRIN1 GRIN1 GNG12 GNG12 ADCY9 ADCY9 GNAI2 GNAI2 GNB4 GNB4 DLGAP1 DLGAP1 GNG11 GNG11 GNAO1 GNAO1 GNG2 GNG2 SLC38A2 SLC38A2 GLUL GLUL PRKCG PRKCG MAPK3 MAPK3 PLCB1 PLCB1 CACNA1C CACNA1C GNG7 GNG7 PLA2G4A PLA2G4A GNG3 GNG3 LOC100732158 LOC100732158 PLCB3 PLCB3 DLG4 DLG4 H0WBW4_CAVPO H0WBW4_CAVPO H0WA79_CAVPO H0WA79_CAVPO CACNA1A CACNA1A ITPR3 ITPR3 GRIK5 GRIK5 SHANK1 SHANK1 GNB3 GNB3 GRM7 GRM7 GRIK3 GRIK3 GNB2 GNB2 SHANK3 SHANK3 LOC106024982 LOC106024982 PRKCA PRKCA HOMER2 HOMER2 ADCY4 ADCY4 ADCY5 ADCY5 GRM3 GRM3 GRIN2A GRIN2A GNB5 GNB5 PLA2G4E PLA2G4E SLC17A6 SLC17A6 MAPK1 MAPK1 SLC1A1 SLC1A1 GLS GLS ITPR2 ITPR2 GRIN3B GRIN3B GNAI3 GNAI3 SLC38A3 SLC38A3 ADCY2 ADCY2 PLD1 PLD1 SLC1A7 SLC1A7 GNG13 GNG13 PPP3CA PPP3CA GRK3 GRK3 SHANK2 SHANK2 H0VE70_CAVPO H0VE70_CAVPO SLC17A8 SLC17A8 GRM5 GRM5 LGSN LGSN GNGT1 GNGT1 PPP3CB PPP3CB SLC1A2 SLC1A2 SLC1A3 SLC1A3 ADCY8 ADCY8 SLC17A7 SLC17A7 GRIN3A GRIN3A PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLD2 PLD2 GRIN2B GRIN2B GRM2 GRM2 ADCY3 ADCY3 PTRHD1 PTRHD1 GNB1 GNB1 SLC38A1 SLC38A1 H0V4J9_CAVPO H0V4J9_CAVPO GRIA1 GRIA1 GRM1 GRM1 GRIA3 GRIA3 PRKCB PRKCB TRPC1 TRPC1 ADCY1 ADCY1 GLS2 GLS2 SLC1A6 SLC1A6 GRIK2 GRIK2 GRIN2C GRIN2C GRM6 GRM6 PPP3CC PPP3CC GRIA4 GRIA4 GRIA2 GRIA2 GRM4 GRM4 GRIK1 GRIK1 Kcnj3 Kcnj3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
PPP3R1Uncharacterized protein. (169 aa)
HOMER1Homer scaffold protein 1. (329 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
LOC100732436Uncharacterized protein. (327 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSCPOP00000030659G_PROTEIN_RECEP_F3_4 domain-containing protein. (497 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAI1Uncharacterized protein. (330 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENSCPOP00000028569ANF_receptor domain-containing protein. (260 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
GNAQG protein subunit alpha q. (313 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
GNB4G protein subunit beta 4. (340 aa)
DLGAP1DLG associated protein 1. (989 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
SLC38A2Solute carrier family 38 member 2. (509 aa)
GLULGlutamine synthetase. (373 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PLA2G4APhospholipase A2. (749 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC100732158Uncharacterized protein. (246 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
H0WA79_CAVPOANF_receptor domain-containing protein. (187 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
GNB3G protein subunit beta 3. (340 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (884 aa)
GNB2G protein subunit beta 2. (378 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
LOC106024982Phospholipase A2. (795 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
HOMER2Homer scaffold protein 2. (357 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
GRM3Glutamate metabotropic receptor 3. (877 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
GNB5G protein subunit beta 5. (406 aa)
PLA2G4EPhospholipase A2. (805 aa)
SLC17A6Solute carrier family 17 member 6. (566 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
SLC1A1Amino acid transporter. (525 aa)
GLSGlutaminase. (649 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (845 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
SLC38A3Solute carrier family 38 member 3. (503 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
PLD1Phospholipase. (1064 aa)
SLC1A7Amino acid transporter. (574 aa)
GNG13G protein subunit gamma 13. (67 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (673 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
SLC17A8Solute carrier family 17 member 8. (476 aa)
GRM5Glutamate metabotropic receptor 5. (873 aa)
LGSNGln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (561 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
SLC1A2Amino acid transporter. (573 aa)
SLC1A3Amino acid transporter. (542 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
PLA2G4FPhospholipase A2. (842 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLD2Phospholipase. (936 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
GRM2Glutamate metabotropic receptor 2. (871 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
GNB1Beta-transducin. (340 aa)
SLC38A1Solute carrier family 38 member 1. (485 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (810 aa)
ADCY1Adenylate cyclase 1. (944 aa)
GLS2Glutaminase 2. (558 aa)
SLC1A6Amino acid transporter. (560 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
GRM6Glutamate metabotropic receptor 6. (794 aa)
PPP3CCSerine/threonine-protein phosphatase. (481 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GRM4Glutamate metabotropic receptor 4. (893 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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