STRINGSTRING
Chrm3 Chrm3 KCNQ5 KCNQ5 CREB3 CREB3 PIK3CB PIK3CB ADCY1 ADCY1 PIK3R6 PIK3R6 MAP2K1 MAP2K1 CHRM5 CHRM5 PRKCB PRKCB CACNA1B CACNA1B KCNQ4 KCNQ4 H0V4J9_CAVPO H0V4J9_CAVPO CHAT CHAT GNB1 GNB1 PTRHD1 PTRHD1 ADCY3 ADCY3 PIK3CA PIK3CA CAMK2A CAMK2A PTK6 PTK6 SRMS SRMS CAMK4 CAMK4 ADCY8 ADCY8 PIK3R1 PIK3R1 GNGT1 GNGT1 CREB3L2 CREB3L2 KCNQ3 KCNQ3 CHRNA6 CHRNA6 PIK3R5 PIK3R5 CREB3L1 CREB3L1 GNG13 GNG13 CREB3L3 CREB3L3 KCNJ6 KCNJ6 CHRNA4 CHRNA4 NRAS NRAS KRAS KRAS ADCY2 ADCY2 GNAI3 GNAI3 ITPR2 ITPR2 CHRNA3 CHRNA3 PIK3CD PIK3CD MAPK1 MAPK1 LOC100730761 LOC100730761 GNB5 GNB5 CREB5 CREB5 ADCY5 ADCY5 ADCY4 ADCY4 JAK2 JAK2 CHRM2 CHRM2 PRKCA PRKCA AKT3 AKT3 ATF4 ATF4 KCNQ1 KCNQ1 Kcnj12 Kcnj12 KCNJ14 KCNJ14 GNB2 GNB2 KCNJ4 KCNJ4 H0W027_CAVPO H0W027_CAVPO CAMK2B CAMK2B SLC18A3 SLC18A3 BCL2 BCL2 GNB3 GNB3 CACNA1F CACNA1F SLC5A7 SLC5A7 ARSI ARSI CHRM1 CHRM1 CHRM4 CHRM4 ITPR3 ITPR3 CACNA1A CACNA1A H0WBW4_CAVPO H0WBW4_CAVPO CHRNB4 CHRNB4 CACNA1S CACNA1S CREB1 CREB1 PLCB3 PLCB3 GNA11 GNA11 FOS FOS GNG3 GNG3 CAMK2G CAMK2G GNG7 GNG7 CACNA1C CACNA1C PLCB1 PLCB1 MAPK3 MAPK3 PRKCG PRKCG GNG2 GNG2 GNAO1 GNAO1 GNG11 GNG11 GNB4 GNB4 GNAI2 GNAI2 FYN FYN KCNQ2 KCNQ2 ADCY9 ADCY9 AKT1 AKT1 GNG12 GNG12 ACHE ACHE Gng5 Gng5 PRKACB PRKACB GNAQ GNAQ PIK3CG PIK3CG GNG8 GNG8 ADCY6 ADCY6 ADCY7 ADCY7 PLCB4 PLCB4 Chrna7 Chrna7 GNG4 GNG4 PLCB2 PLCB2 GNAI1 GNAI1 LOC100734206 LOC100734206 ENSCPOP00000030509 ENSCPOP00000030509 CREB3L4 CREB3L4 ITPR1 ITPR1 Camk2d Camk2d Chrnb2 Chrnb2 Kcnj2 Kcnj2 GNGT2 GNGT2 ENSCPOP00000031524 ENSCPOP00000031524 AKT2 AKT2 CSDE1 CSDE1 CACNA1D CACNA1D HRAS HRAS Prkaca Prkaca Kcnj3 Kcnj3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (908 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
ADCY1Adenylate cyclase 1. (944 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (763 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (530 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (699 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (621 aa)
GNB1Beta-transducin. (340 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
PTK6Tyrosine-protein kinase. (451 aa)
SRMSTyrosine-protein kinase. (508 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (860 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (886 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
GNG13G protein subunit gamma 13. (67 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (429 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (506 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
GNB5G protein subunit beta 5. (406 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
ATF4Activating transcription factor 4. (354 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
Kcnj12Uncharacterized protein. (535 aa)
KCNJ14Inwardly-rectifying potassium channel Kir2.4. (439 aa)
GNB2G protein subunit beta 2. (378 aa)
KCNJ4Uncharacterized protein. (443 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
SLC18A3Solute carrier family 18 member A3. (533 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
ARSIArylsulfatase family member I. (572 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
FYNTyrosine-protein kinase. (537 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (871 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (613 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1092 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
Chrna7Uncharacterized protein. (483 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNAI1Uncharacterized protein. (330 aa)
LOC100734206Uncharacterized protein. (461 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
Chrnb2Uncharacterized protein. (499 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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