STRINGSTRING
MAPK1 MAPK1 GNA13 GNA13 ARAF ARAF PLA2G4E PLA2G4E PRKCA PRKCA GUCY1B1 GUCY1B1 PRKG2 PRKG2 LOC106024982 LOC106024982 RYR1 RYR1 MAP2K2 MAP2K2 H0W160_CAVPO H0W160_CAVPO ITPR3 ITPR3 CACNA1A CACNA1A LOC100718831 LOC100718831 PLCB3 PLCB3 GNA11 GNA11 LOC100732158 LOC100732158 GNAZ GNAZ PLA2G4A PLA2G4A PLCB1 PLCB1 MAPK3 MAPK3 PPP2CA PPP2CA PRKCG PRKCG PPP2R1B PPP2R1B GNAO1 GNAO1 GNAI2 GNAI2 PRKG1 PRKG1 GNAQ GNAQ PLCB4 PLCB4 PLCB2 PLCB2 GNAI1 GNAI1 CRH CRH ITPR1 ITPR1 LOC100732436 LOC100732436 BRAF BRAF ENSCPOP00000031664 ENSCPOP00000031664 CSDE1 CSDE1 IGF1 IGF1 HRAS HRAS GUCY1A2 GUCY1A2 GRIA2 GRIA2 RAF1 RAF1 GNA12 GNA12 MAP2K1 MAP2K1 PRKCB PRKCB GRIA3 GRIA3 H0V1A0_CAVPO H0V1A0_CAVPO GRM1 GRM1 GRIA1 GRIA1 PPP2CB PPP2CB IGF1R IGF1R H0V5P5_CAVPO H0V5P5_CAVPO PLA2G4D PLA2G4D PLA2G4F PLA2G4F LOC100734047 LOC100734047 H0VE70_CAVPO H0VE70_CAVPO PPP1R17 PPP1R17 NRAS NRAS KRAS KRAS GUCY1A1 GUCY1A1 GNAI3 GNAI3 GRID2 GRID2 LYN LYN ITPR2 ITPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (325 aa)
GNA13G protein subunit alpha 13. (377 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (608 aa)
PLA2G4EPhospholipase A2. (805 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
PRKG2cGMP-dependent protein kinase. (758 aa)
LOC106024982Phospholipase A2. (795 aa)
RYR1Ryanodine receptor 1. (4554 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
LOC100718831YccV-like domain-containing protein. (514 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
LOC100732158Uncharacterized protein. (246 aa)
GNAZG protein subunit alpha z. (355 aa)
PLA2G4APhospholipase A2. (749 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
GNAQG protein subunit alpha q. (313 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNAI1Uncharacterized protein. (330 aa)
CRHCorticotropin releasing hormone. (193 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
LOC100732436Uncharacterized protein. (327 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
ENSCPOP00000031664Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (702 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (635 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
GNA12G protein subunit alpha 12. (315 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
H0V1A0_CAVPOYccV-like domain-containing protein. (541 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
H0V5P5_CAVPOUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLA2G4FPhospholipase A2. (842 aa)
LOC100734047Uncharacterized protein. (567 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PPP1R17Protein phosphatase 1 regulatory subunit 17. (155 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
LYNTyrosine-protein kinase. (512 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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