STRINGSTRING
LOC100734206 LOC100734206 HTR2C HTR2C ITPR1 ITPR1 Camk2d Camk2d IL1R1 IL1R1 AADACL2 AADACL2 LOC100732436 LOC100732436 IGF1 IGF1 ENSCPOP00000032059 ENSCPOP00000032059 HTR2A HTR2A Prkaca Prkaca MAPK10 MAPK10 BDKRB2 BDKRB2 NGF NGF ASIC2 ASIC2 PLCB3 PLCB3 LOC100732158 LOC100732158 PLA2G6 PLA2G6 MAP2K6 MAP2K6 MAPK14 MAPK14 PLA2G4A PLA2G4A CAMK2G CAMK2G PPP1CA PPP1CA ASIC4 ASIC4 ASIC3 ASIC3 PTGER2 PTGER2 PLCB1 PLCB1 PPP1CB PPP1CB CALML4 CALML4 MAPK11 MAPK11 PRKCG PRKCG MAPK8 MAPK8 F2RL1 F2RL1 MAP2K3 MAP2K3 H0UTG5_CAVPO H0UTG5_CAVPO ASIC1 ASIC1 HTR2B HTR2B PTGER4 PTGER4 PIK3CB PIK3CB CALM2 CALM2 IL1B IL1B PLCG2 PLCG2 CALM1 CALM1 ADCY1 ADCY1 NTRK1 NTRK1 PRKCB PRKCB ALOX12 ALOX12 AADAC AADAC Trpm8 Trpm8 PTRHD1 PTRHD1 ADCY3 ADCY3 PPP1CC PPP1CC CYP2W1 CYP2W1 PLA2G4D PLA2G4D PLA2G4F PLA2G4F PIK3CA PIK3CA CAMK2A CAMK2A ADCY8 ADCY8 PIK3R1 PIK3R1 ASIC5 ASIC5 H0VE70_CAVPO H0VE70_CAVPO Prkch Prkch LOC100716044 LOC100716044 TRPV1 TRPV1 LOC100719356 LOC100719356 ADCY2 ADCY2 H0VIC7_CAVPO H0VIC7_CAVPO LOC100723678 LOC100723678 Trpa1 Trpa1 H0VKV0_CAVPO H0VKV0_CAVPO ITPR2 ITPR2 TRPV2 TRPV2 KNG1 KNG1 PIK3CD PIK3CD PLA2G4E PLA2G4E ADCY5 ADCY5 CALML3 CALML3 LOC100721360 LOC100721360 ADCY4 ADCY4 MAPK13 MAPK13 MAPK12 MAPK12 PRKCA PRKCA TRPV3 TRPV3 LOC106024982 LOC106024982 PRKCE PRKCE PLCG1 PLCG1 IL1RAP IL1RAP H0W027_CAVPO H0W027_CAVPO CAMK2B CAMK2B HRH1 HRH1 LOC100719677 LOC100719677 H0W5X3_CAVPO H0W5X3_CAVPO H0W627_CAVPO H0W627_CAVPO LOC100729591 LOC100729591 ARSI ARSI LOC100713503 LOC100713503 ITPR3 ITPR3 LOC100719102 LOC100719102 MAPK9 MAPK9 ADCY9 ADCY9 PRKCD PRKCD PRKACB PRKACB GNAQ GNAQ PRKCQ PRKCQ P2RY2 P2RY2 TRPV4 TRPV4 ADCY6 ADCY6 ADCY7 ADCY7 CALM3 CALM3 PLCB4 PLCB4 PLCB2 PLCB2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC100734206Uncharacterized protein. (461 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
AADACL2Arylacetamide deacetylase like 2. (401 aa)
LOC100732436Uncharacterized protein. (327 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
BDKRB2B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (399 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. (308 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
LOC100732158Uncharacterized protein. (246 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLA2G4APhospholipase A2. (749 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (539 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
CALML4Calmodulin like 4. (153 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
F2RL1F2R like trypsin receptor 1. (399 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
H0UTG5_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (509 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
PTGER4Prostaglandin E2 receptor 4; Belongs to the G-protein coupled receptor 1 family. (487 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
ADCY1Adenylate cyclase 1. (944 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (656 aa)
AADACArylacetamide deacetylase. (353 aa)
Trpm8Transient potential cation channel subfamily M member 8. (1104 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (496 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLA2G4FPhospholipase A2. (842 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PrkchUncharacterized protein. (543 aa)
LOC100716044Cytochrome P450 2C-like protein; Belongs to the cytochrome P450 family. (490 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
LOC100719356Uncharacterized protein; Belongs to the cytochrome P450 family. (511 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
H0VIC7_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (460 aa)
LOC100723678Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (720 aa)
KNG1Kininogen 1. (625 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PLA2G4EPhospholipase A2. (805 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
LOC100721360Uncharacterized protein. (401 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
LOC106024982Phospholipase A2. (795 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
IL1RAPInterleukin 1 receptor accessory protein. (685 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa)
LOC100719677Uncharacterized protein. (662 aa)
H0W5X3_CAVPOUncharacterized protein; Belongs to the cytochrome P450 family. (284 aa)
H0W627_CAVPOUncharacterized protein. (270 aa)
LOC100729591Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
ARSIArylsulfatase family member I. (572 aa)
LOC100713503Uncharacterized protein; Belongs to the cytochrome P450 family. (510 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
LOC100719102Uncharacterized protein. (449 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
CALM3Calmodulin 3. (149 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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