STRINGSTRING
SLC2A1 SLC2A1 KCNN2 KCNN2 KCNN4 KCNN4 ABCC8 ABCC8 RAB3C RAB3C ADCY1 ADCY1 SNAP25 SNAP25 STX1A STX1A PRKCB PRKCB ATP1B3 ATP1B3 PTRHD1 PTRHD1 ADCY3 ADCY3 ADCYAP1R1 ADCYAP1R1 CAMK2A CAMK2A CCKAR CCKAR ADCY8 ADCY8 RIMS2 RIMS2 RAB3B RAB3B CREB3L2 CREB3L2 H0VE70_CAVPO H0VE70_CAVPO PCLO PCLO CREB3L1 CREB3L1 CREB3L3 CREB3L3 Atp1a3 Atp1a3 RAPGEF4 RAPGEF4 ADCY2 ADCY2 FAP FAP SLC2A2 SLC2A2 TNIK TNIK CREB5 CREB5 ADCY5 ADCY5 Kcnmb2 Kcnmb2 ADCY4 ADCY4 PRKCA PRKCA LOC100721783 LOC100721783 ADCYAP1 ADCYAP1 GLP1R GLP1R KCNN3 KCNN3 ATF4 ATF4 GCG GCG Ffar1 Ffar1 GPR119 GPR119 CAMK2B CAMK2B Chrm3 Chrm3 CACNA1F CACNA1F GIP GIP ARSI ARSI KCNN1 KCNN1 ITPR3 ITPR3 KCNU1 KCNU1 KCNJ11 KCNJ11 Fxyd2 Fxyd2 PDX1 PDX1 H0WB32_CAVPO H0WB32_CAVPO TRPM4 TRPM4 CACNA1S CACNA1S CREB1 CREB1 PLCB3 PLCB3 GNA11 GNA11 LOC100732158 LOC100732158 CCK CCK KCNMB1 KCNMB1 CAMK2G CAMK2G CACNA1C CACNA1C PLCB1 PLCB1 ATP1A4 ATP1A4 PRKCG PRKCG ATP1B2 ATP1B2 ATP1B4 ATP1B4 ADCY9 ADCY9 ATP1A1 ATP1A1 PRKACB PRKACB GNAQ GNAQ ATF6B ATF6B INS INS KCNMA1 KCNMA1 ADCY6 ADCY6 RYR2 RYR2 ADCY7 ADCY7 ATP1B1 ATP1B1 PLCB4 PLCB4 RAB3A RAB3A ATP1A2 ATP1A2 PLCB2 PLCB2 GCK GCK CREB3L4 CREB3L4 Camk2d Camk2d Vamp2 Vamp2 ATF2 ATF2 LOC100732436 LOC100732436 CACNA1D CACNA1D Prkaca Prkaca CREB3 CREB3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
KCNN4Intermediate-conductance calcium-activated potassium channel. (427 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
RAB3CRAB3C, member RAS oncogene family. (227 aa)
ADCY1Adenylate cyclase 1. (944 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CCKARCholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (430 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1410 aa)
RAB3BRAB3B, member RAS oncogene family. (219 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PCLOPiccolo presynaptic cytomatrix protein. (3548 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (725 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
Kcnmb2KcnmB2_inactiv domain-containing protein. (235 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
LOC100721783G_PROTEIN_RECEP_F1_2 domain-containing protein. (300 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (180 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (720 aa)
ATF4Activating transcription factor 4. (354 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
Ffar1annotation not available (300 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
GIPGastric inhibitory polypeptide. (145 aa)
ARSIArylsulfatase family member I. (572 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (558 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (981 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
Fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
PDX1Pancreatic and duodenal homeobox 1. (223 aa)
H0WB32_CAVPOSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (177 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
LOC100732158Uncharacterized protein. (246 aa)
CCKCholecystokinin. (115 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
ATF6BActivating transcription factor 6 beta. (694 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
RYR2Ryanodine receptor 2. (4910 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GCKPhosphotransferase. (414 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC100732436Uncharacterized protein. (327 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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