STRINGSTRING
MAPK3 MAPK3 MAPK9 MAPK9 GNAI2 GNAI2 ADCY9 ADCY9 AKT1 AKT1 CDC25A CDC25A PRKACB PRKACB AURKB AURKB INS INS ADCY6 ADCY6 CDC26 CDC26 ADCY7 ADCY7 ANAPC13 ANAPC13 ANAPC1 ANAPC1 ENSCPOP00000029129 ENSCPOP00000029129 GNAI1 GNAI1 LOC100734206 LOC100734206 AP5S1 AP5S1 CPEB3 CPEB3 ENSCPOP00000030888 ENSCPOP00000030888 PLK1 PLK1 Ccnb1 Ccnb1 CDC27 CDC27 AKT2 AKT2 BRAF BRAF REM1 REM1 MAD2L1 MAD2L1 IGF1 IGF1 Prkaca Prkaca MAPK10 MAPK10 BUB1 BUB1 ANAPC4 ANAPC4 ARAF ARAF MAPK1 MAPK1 PIK3CD PIK3CD AURKC AURKC TMEM82 TMEM82 ANAPC5 ANAPC5 GNAI3 GNAI3 ADCY2 ADCY2 CDC23 CDC23 CCNA2 CCNA2 CDK2 CDK2 ANAPC2 ANAPC2 GEM GEM PKMYT1 PKMYT1 PIK3R1 PIK3R1 CDC25B CDC25B ADCY8 ADCY8 Aurka Aurka PIK3CA PIK3CA STK10 STK10 ADCY3 ADCY3 PTRHD1 PTRHD1 Cdk1 Cdk1 IGF1R IGF1R CDC16 CDC16 HSP90AB1 HSP90AB1 MAP2K1 MAP2K1 ADCY1 ADCY1 MAD1L1 MAD1L1 KIF22 KIF22 Hsp90aa1 Hsp90aa1 RAF1 RAF1 CPEB2 CPEB2 PIK3CB PIK3CB Anapc11 Anapc11 ADCY5 ADCY5 ADCY4 ADCY4 PDE3B PDE3B MAPK13 MAPK13 MAPK12 MAPK12 AKT3 AKT3 CPEB4 CPEB4 ANAPC7 ANAPC7 H0VW22_CAVPO H0VW22_CAVPO LOC100720222 LOC100720222 H0W027_CAVPO H0W027_CAVPO MOS MOS SPDYA SPDYA CCNB2 CCNB2 RRAD RRAD MAD2L2 MAD2L2 Cpeb1 Cpeb1 H0WBA3_CAVPO H0WBA3_CAVPO CCNA1 CCNA1 MAPK14 MAPK14 RPS6KA2 RPS6KA2 Ccnb3 Ccnb3 LOC100725824 LOC100725824 RPS6KA3 RPS6KA3 ANAPC10 ANAPC10 RPS6KA1 RPS6KA1 FZR1 FZR1 Pgr Pgr MAPK11 MAPK11 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDC25ACell division cycle 25A. (519 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (339 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CDC26Cell division cycle 26. (85 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ANAPC13Anaphase promoting complex subunit 13. (74 aa)
ANAPC1Anaphase promoting complex subunit 1. (1941 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
GNAI1Uncharacterized protein. (330 aa)
LOC100734206Uncharacterized protein. (461 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (588 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
Ccnb1annotation not available (423 aa)
CDC27Cell division cycle 27. (825 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1031 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (608 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (257 aa)
TMEM82Transmembrane protein 82. (356 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CDC23Cell division cycle 23. (597 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (429 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (827 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
PKMYT1Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (490 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CDC25BCell division cycle 25B. (579 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
AurkaProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (384 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
STK10Serine/threonine kinase 10. (959 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CDC16Cell division cycle 16. (620 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY1Adenylate cyclase 1. (944 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (717 aa)
KIF22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (681 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (564 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
Anapc11RING-type domain-containing protein. (84 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PDE3BPhosphodiesterase. (931 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (636 aa)
ANAPC7Anaphase promoting complex subunit 7. (555 aa)
H0VW22_CAVPOProtein kinase domain-containing protein. (399 aa)
LOC100720222Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (357 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (295 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
Cpeb1RRM domain-containing protein. (560 aa)
H0WBA3_CAVPOUncharacterized protein. (184 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (420 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
Ccnb3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1277 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
PgrUncharacterized protein. (428 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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