STRINGSTRING
FZD3 FZD3 WNT7B WNT7B WNT7A WNT7A WNT11 WNT11 CREB3L2 CREB3L2 ADCY8 ADCY8 DVL1 DVL1 CAMK2A CAMK2A ADCY3 ADCY3 PTRHD1 PTRHD1 EP300 EP300 ASIP ASIP PRKCB PRKCB MAP2K1 MAP2K1 ADCY1 ADCY1 CALM1 CALM1 DCT DCT CALM2 CALM2 RAF1 RAF1 WNT8A WNT8A CREB3 CREB3 WNT2B WNT2B EFCAB3 EFCAB3 TCF7 TCF7 CREB1 CREB1 PLCB3 PLCB3 LOC100732158 LOC100732158 TCF7L2 TCF7L2 DVL3 DVL3 CAMK2G CAMK2G WNT5A WNT5A PLCB1 PLCB1 LEF1 LEF1 CALML4 CALML4 WNT2 WNT2 MAPK3 MAPK3 PRKCG PRKCG WNT3A WNT3A GNAO1 GNAO1 GNAI2 GNAI2 ADCY9 ADCY9 WNT10A WNT10A WNT9A WNT9A FZD9 FZD9 PRKACB PRKACB GNAQ GNAQ KITLG KITLG ADCY6 ADCY6 ADCY7 ADCY7 WNT6 WNT6 CALM3 CALM3 WNT16 WNT16 MC1R MC1R WNT10B WNT10B EDN1 EDN1 PLCB4 PLCB4 PLCB2 PLCB2 FZD2 FZD2 FZD5 FZD5 GNAI1 GNAI1 FZD10 FZD10 CREB3L4 CREB3L4 Camk2d Camk2d LOC100732436 LOC100732436 REM1 REM1 WNT5B WNT5B CREBBP CREBBP CSDE1 CSDE1 ENSCPOP00000032059 ENSCPOP00000032059 WNT4 WNT4 CTNNB1 CTNNB1 HRAS HRAS Prkaca Prkaca PRKCA PRKCA MITF MITF EDNRB EDNRB MAP2K2 MAP2K2 WNT1 WNT1 FZD7 FZD7 CAMK2B CAMK2B RRAD RRAD FZD1 FZD1 DVL2 DVL2 ARSI ARSI WNT8B WNT8B POMC POMC TCF7L1 TCF7L1 ADCY4 ADCY4 FZD4 FZD4 GSK3B GSK3B CALML3 CALML3 TYRP1 TYRP1 ADCY5 ADCY5 MAPK1 MAPK1 FZD6 FZD6 H0VKV0_CAVPO H0VKV0_CAVPO GNAI3 GNAI3 KIT KIT ADCY2 ADCY2 KRAS KRAS NRAS NRAS TYR TYR CREB3L3 CREB3L3 CREB3L1 CREB3L1 GEM GEM WNT9B WNT9B WNT3 WNT3 H0VE70_CAVPO H0VE70_CAVPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
EP300E1A binding protein p300. (2425 aa)
ASIPAgouti signaling protein. (130 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY1Adenylate cyclase 1. (944 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
DCTDopachrome tautomerase. (517 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
EFCAB3EF-hand calcium binding domain 3. (436 aa)
TCF7Transcription factor 7. (262 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
LOC100732158Uncharacterized protein. (246 aa)
TCF7L2Transcription factor 7 like 2. (350 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
CALML4Calmodulin like 4. (153 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CALM3Calmodulin 3. (149 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
MC1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (316 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
GNAI1Uncharacterized protein. (330 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (505 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
LOC100732436Uncharacterized protein. (327 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
CREBBPCREB binding protein. (2441 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
CTNNB1Catenin beta 1. (781 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
ARSIArylsulfatase family member I. (572 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
TYRP1Tyrosinase related protein 1. (469 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
TYRTyrosinase. (530 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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