STRINGSTRING
ITPR1 ITPR1 GPX8 GPX8 LOC100732436 LOC100732436 TSHR TSHR ENSCPOP00000032160 ENSCPOP00000032160 Prkaca Prkaca PAX8 PAX8 PLCB2 PLCB2 GPX7 GPX7 ATP1A2 ATP1A2 PLCB4 PLCB4 HSP90B1 HSP90B1 ATP1B1 ATP1B1 ADCY7 ADCY7 ASGR2 ASGR2 ADCY6 ADCY6 ATF6B ATF6B GNAQ GNAQ PRKACB PRKACB ENSCPOP00000026517 ENSCPOP00000026517 ATP1A1 ATP1A1 GPX2 GPX2 ADCY9 ADCY9 ATP1B4 ATP1B4 TSHB TSHB ENSCPOP00000024732 ENSCPOP00000024732 ATP1B2 ATP1B2 PRKCG PRKCG ENSCPOP00000024297 ENSCPOP00000024297 ATP1A4 ATP1A4 PLCB1 PLCB1 LOC100732158 LOC100732158 PLCB3 PLCB3 CREB1 CREB1 H0WB32_CAVPO H0WB32_CAVPO Fxyd2 Fxyd2 Ttf1 Ttf1 ITPR3 ITPR3 Iyd Iyd H0W3X9_CAVPO H0W3X9_CAVPO ATF4 ATF4 PRKCA PRKCA ADCY4 ADCY4 H0VQJ6_CAVPO H0VQJ6_CAVPO ADCY5 ADCY5 CREB5 CREB5 TTR TTR SYCP1 SYCP1 Hspa5 Hspa5 ITPR2 ITPR2 ADCY2 ADCY2 Atp1a3 Atp1a3 CREB3L3 CREB3L3 CREB3L1 CREB3L1 ASGR1 ASGR1 TG TG LOC100714742 LOC100714742 CGA CGA H0VE70_CAVPO H0VE70_CAVPO SERPINA7 SERPINA7 CREB3L2 CREB3L2 DUOX1 DUOX1 DUOX2 DUOX2 ADCY8 ADCY8 GPX3 GPX3 ADCY3 ADCY3 PTRHD1 PTRHD1 SERPINA9 SERPINA9 GSR GSR DUOXA2 DUOXA2 PDIA4 PDIA4 ATP1B3 ATP1B3 PRKCB PRKCB CANX CANX Alb Alb Gpx5 Gpx5 ADCY1 ADCY1 SLC26A4 SLC26A4 SLC5A5 SLC5A5 Ttf2 Ttf2 CREB3 CREB3 CREB3L4 CREB3L4 ATF2 ATF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
LOC100732436Uncharacterized protein. (327 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (763 aa)
ENSCPOP00000032160Uncharacterized protein; Belongs to the heat shock protein 70 family. (609 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PAX8Paired box 8. (457 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
HSP90B1Heat shock protein 90 beta family member 1. (807 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ASGR2Asialoglycoprotein receptor 2. (302 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ATF6BActivating transcription factor 6 beta. (694 aa)
GNAQG protein subunit alpha q. (313 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSCPOP00000026517Uncharacterized protein. (74 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
GPX2Glutathione peroxidase 2. (162 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
TSHBThyroid stimulating hormone beta subunit. (138 aa)
ENSCPOP00000024732Uncharacterized protein. (121 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
LOC100732158Uncharacterized protein. (246 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
H0WB32_CAVPOSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (177 aa)
Fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
Ttf1Myb-like domain-containing protein. (335 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
IydNitroreductase domain-containing protein. (285 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
ATF4Activating transcription factor 4. (354 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
H0VQJ6_CAVPONitroreductase domain-containing protein. (193 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
TTRTransthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. (131 aa)
SYCP1Synaptonemal complex protein 1. (931 aa)
Hspa5Uncharacterized protein; Belongs to the heat shock protein 70 family. (655 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
ASGR1Asialoglycoprotein receptor 1. (291 aa)
TGThyroglobulin. (2742 aa)
LOC100714742C-type lectin domain-containing protein. (305 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
SERPINA7Serpin family A member 7; Belongs to the serpin family. (406 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
DUOX1Dual oxidase 1. (1551 aa)
DUOX2Dual oxidase 2. (1517 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
SERPINA9Serpin family A member 9; Belongs to the serpin family. (417 aa)
GSRGlutathione-disulfide reductase. (418 aa)
DUOXA2Dual oxidase maturation factor 2. (320 aa)
PDIA4Protein disulfide-isomerase A4. (644 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
CANXCalnexin. (593 aa)
AlbPreproalbumin. (608 aa)
Gpx5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (224 aa)
ADCY1Adenylate cyclase 1. (944 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (739 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (617 aa)
Ttf2Uncharacterized protein. (1148 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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