STRINGSTRING
H0V006_CAVPO H0V006_CAVPO CHUK CHUK ACSL3 ACSL3 CAMKK2 CAMKK2 AKT2 AKT2 LOC100734633 LOC100734633 ENSCPOP00000030085 ENSCPOP00000030085 G6PC2 G6PC2 PRKAB2 PRKAB2 LEP LEP TNFRSF1A TNFRSF1A RXRG RXRG ADIPOQ ADIPOQ PRKCQ PRKCQ CPT1A CPT1A TRAF2 TRAF2 AKT1 AKT1 STK11 STK11 CD36 CD36 STAT3 STAT3 MAPK9 MAPK9 MAPK8 MAPK8 SLC2A4 SLC2A4 PPARGC1A PPARGC1A ACSBG1 ACSBG1 IKBKG IKBKG POMC POMC NFKBIE NFKBIE TNFRSF1B TNFRSF1B NPY NPY SOCS3 SOCS3 PRKAG3 PRKAG3 LOC100722851 LOC100722851 RELA RELA PRKAG2 PRKAG2 Prkab1 Prkab1 AKT3 AKT3 CPT1C CPT1C LOC100732110 LOC100732110 LEPR LEPR JAK2 JAK2 LOC100723127 LOC100723127 RXRB RXRB PTPN11 PTPN11 G6PC G6PC NFKBIB NFKBIB H0VM53_CAVPO H0VM53_CAVPO MTOR MTOR PCK2 PCK2 AGRP AGRP TRADD TRADD IKBKB IKBKB PRKAA2 PRKAA2 NFKB1 NFKB1 IRS4 IRS4 CPT1B CPT1B PCK1 PCK1 ACSL5 ACSL5 NOSTRIN NOSTRIN NFKBIA NFKBIA PRKAA1 PRKAA1 IRS1 IRS1 ADIPOR2 ADIPOR2 ACACB ACACB MAPK10 MAPK10 PRKAG1 PRKAG1 Acsl1 Acsl1 G6PC3 G6PC3 TNF TNF ACSL4 ACSL4 PPARA PPARA SLC2A1 SLC2A1 ADIPOR1 ADIPOR1 RXRA RXRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0V006_CAVPOMFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (489 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (565 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC100734633MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (496 aa)
ENSCPOP00000030085AMPKBI domain-containing protein. (256 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
RXRGRetinoid X receptor gamma. (499 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (739 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
NFKBIENFKB inhibitor epsilon. (341 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
SOCS3Suppressor of cytokine signaling 3. (228 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (465 aa)
LOC100722851AMP-binding domain-containing protein. (764 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
Prkab1AMPKBI domain-containing protein. (270 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (807 aa)
LOC100732110MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (482 aa)
LEPRLeptin receptor. (1174 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
LOC100723127AMP-binding domain-containing protein. (473 aa)
RXRBRetinoid X receptor beta. (414 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
NFKBIBNFKB inhibitor beta. (355 aa)
H0VM53_CAVPOAMP-binding domain-containing protein. (696 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (652 aa)
AGRPAgouti related neuropeptide. (132 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
IRS4Insulin receptor substrate 4. (1217 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ACSL5AMP-binding domain-containing protein. (682 aa)
NOSTRINNitric oxide synthase trafficking. (471 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
Acsl1Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family. (698 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (707 aa)
PPARAPeroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (467 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
RXRARetinoid X receptor alpha. (459 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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