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ADRB1 ADRB1 NPY NPY ADRB2 ADRB2 PMP2 PMP2 PLAAT3 PLAAT3 LOC100732158 LOC100732158 LIPE LIPE PLIN1 PLIN1 GNAI2 GNAI2 TSHB TSHB PRKG1 PRKG1 ADCY9 ADCY9 AKT1 AKT1 MGLL MGLL PTGER3 PTGER3 PRKACB PRKACB INS INS ADCY6 ADCY6 ADCY7 ADCY7 ABHD5 ABHD5 ADORA1 ADORA1 GNAI1 GNAI1 LOC100734206 LOC100734206 LOC100732436 LOC100732436 AKT2 AKT2 TSHR TSHR FABP4 FABP4 Prkaca Prkaca PIK3CB PIK3CB PTGS2 PTGS2 PLAAT2 PLAAT2 ADCY1 ADCY1 IRS1 IRS1 PTRHD1 PTRHD1 ADCY3 ADCY3 PNPLA2 PNPLA2 PIK3CA PIK3CA ADCY8 ADCY8 PTGS1 PTGS1 IRS4 IRS4 PIK3R1 PIK3R1 H0VE70_CAVPO H0VE70_CAVPO CGA CGA ADCY2 ADCY2 GNAI3 GNAI3 FABP12 FABP12 Aqp7 Aqp7 SYCP1 SYCP1 PIK3CD PIK3CD INSR INSR ADCY5 ADCY5 ADCY4 ADCY4 PDE3B PDE3B PRKG2 PRKG2 AKT3 AKT3 NPPA NPPA H0W027_CAVPO H0W027_CAVPO NPR1 NPR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
PMP2Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
PLAAT3Phospholipase A and acyltransferase 3. (162 aa)
LOC100732158Uncharacterized protein. (246 aa)
LIPELipase E, hormone sensitive type. (802 aa)
PLIN1Perilipin; Belongs to the perilipin family. (515 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
TSHBThyroid stimulating hormone beta subunit. (138 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MGLLMonoglyceride lipase. (314 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
ABHD5Abhydrolase domain containing 5. (380 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (326 aa)
GNAI1Uncharacterized protein. (330 aa)
LOC100734206Uncharacterized protein. (461 aa)
LOC100732436Uncharacterized protein. (327 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (763 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
PLAAT2Phospholipase A and acyltransferase 2. (167 aa)
ADCY1Adenylate cyclase 1. (944 aa)
IRS1Insulin receptor substrate 1. (1243 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PNPLA2Patatin like phospholipase domain containing 2. (486 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (553 aa)
IRS4Insulin receptor substrate 4. (1217 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
FABP12Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (107 aa)
Aqp7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (326 aa)
SYCP1Synaptonemal complex protein 1. (931 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PDE3BPhosphodiesterase. (931 aa)
PRKG2cGMP-dependent protein kinase. (758 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
NPR1Guanylate cyclase. (881 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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