STRINGSTRING
ADCY6 ADCY6 CALM3 CALM3 EDN3 EDN3 EDN1 EDN1 GUCY1A2 GUCY1A2 PTGER4 PTGER4 LOC100727546 LOC100727546 PPP3CC PPP3CC CALM2 CALM2 ACE ACE CALM1 CALM1 EDNRA EDNRA ADCYAP1R1 ADCYAP1R1 AGTR1 AGTR1 PPP3CB PPP3CB CTSB CTSB H0VE70_CAVPO H0VE70_CAVPO PPP3CA PPP3CA GUCY1A1 GUCY1A1 EDN2 EDN2 PDE3A PDE3A Aqp1 Aqp1 GNAI3 GNAI3 H0VKV0_CAVPO H0VKV0_CAVPO ITPR2 ITPR2 ADCY5 ADCY5 CALML3 CALML3 PDE3B PDE3B GUCY1B1 GUCY1B1 PRKG2 PRKG2 CLCA2 CLCA2 CLCA1 CLCA1 LOC100727821 LOC100727821 PDE1B PDE1B ADCYAP1 ADCYAP1 LOC100726159 LOC100726159 LOC100712658 LOC100712658 H0VWU3_CAVPO H0VWU3_CAVPO PLCB4 PLCB4 NPPA NPPA REN REN NPR1 NPR1 ADRB1 ADRB1 CACNA1F CACNA1F ADRB2 ADRB2 LOC100735910 LOC100735910 H0W5Z7_CAVPO H0W5Z7_CAVPO LOC100714182 LOC100714182 ORAI1 ORAI1 ITPR3 ITPR3 AGT AGT CACNA1S CACNA1S CREB1 CREB1 PLCB3 PLCB3 LOC100732158 LOC100732158 CACNA1C CACNA1C Prkaca Prkaca CACNA1D CACNA1D ENSCPOP00000032059 ENSCPOP00000032059 PPP3R1 PPP3R1 ENSCPOP00000031664 ENSCPOP00000031664 LOC100732436 LOC100732436 Kcnj2 Kcnj2 MINDY4 MINDY4 PDE1A PDE1A ITPR1 ITPR1 GNAI1 GNAI1 PLCB2 PLCB2 ADORA1 ADORA1 PDE1C PDE1C PTGER2 PTGER2 PLCB1 PLCB1 CALML4 CALML4 GNAI2 GNAI2 ENSCPOP00000025593 ENSCPOP00000025593 PRKACB PRKACB GNAQ GNAQ KCNMA1 KCNMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
CALM3Calmodulin 3. (149 aa)
EDN3Endothelin 3. (200 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (635 aa)
PTGER4Prostaglandin E2 receptor 4; Belongs to the G-protein coupled receptor 1 family. (487 aa)
LOC100727546VWFA domain-containing protein. (923 aa)
PPP3CCSerine/threonine-protein phosphatase. (481 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
ACEAngiotensin-converting enzyme. (1302 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (340 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
EDN2Endothelin 2. (179 aa)
PDE3APhosphodiesterase. (1132 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PDE3BPhosphodiesterase. (931 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
PRKG2cGMP-dependent protein kinase. (758 aa)
CLCA2Chloride channel accessory 2. (861 aa)
CLCA1Chloride channel accessory 1. (913 aa)
LOC100727821VWFA domain-containing protein. (923 aa)
PDE1BPhosphodiesterase. (535 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (180 aa)
LOC100726159VWFA domain-containing protein. (911 aa)
LOC100712658Angiotensin-converting enzyme. (718 aa)
H0VWU3_CAVPOAngiotensin-converting enzyme. (685 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
RENRenin; Belongs to the peptidase A1 family. (403 aa)
NPR1Guanylate cyclase. (881 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
LOC100735910Angiotensin-converting enzyme. (706 aa)
H0W5Z7_CAVPOAngiotensin-converting enzyme. (622 aa)
LOC100714182Angiotensin-converting enzyme. (701 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
LOC100732158Uncharacterized protein. (246 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
PPP3R1Uncharacterized protein. (169 aa)
ENSCPOP00000031664Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (702 aa)
LOC100732436Uncharacterized protein. (327 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
MINDY4MINDY lysine 48 deubiquitinase 4. (779 aa)
PDE1APhosphodiesterase. (531 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
GNAI1Uncharacterized protein. (330 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (326 aa)
PDE1CPhosphodiesterase. (685 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CALML4Calmodulin like 4. (153 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
ENSCPOP00000025593Uncharacterized protein. (180 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.