STRINGSTRING
CALM1 CALM1 ADCY1 ADCY1 LOC100727788 LOC100727788 NR4A1 NR4A1 PRKD2 PRKD2 STAR STAR PRKCB PRKCB ATP1B3 ATP1B3 CAMK1G CAMK1G PRKD1 PRKD1 PTRHD1 PTRHD1 CREB3 CREB3 LOC100716515 LOC100716515 ADCY3 ADCY3 CAMK2A CAMK2A CAMK4 CAMK4 ADCY8 ADCY8 AGTR1 AGTR1 NR4A2 NR4A2 LOC100725801 LOC100725801 DAGLB DAGLB CAMK1 CAMK1 CREB3L2 CREB3L2 H0VE70_CAVPO H0VE70_CAVPO CREB3L1 CREB3L1 CREB3L3 CREB3L3 Atp1a3 Atp1a3 ADCY2 ADCY2 CACNA1I CACNA1I H0VKV0_CAVPO H0VKV0_CAVPO PRKD3 PRKD3 CACNA1H CACNA1H ITPR2 ITPR2 DAGLA DAGLA CREB5 CREB5 ADCY5 ADCY5 CALML3 CALML3 ADCY4 ADCY4 PRKCA PRKCA ATF4 ATF4 PRKCE PRKCE KCNK3 KCNK3 NPPA NPPA CAMK2B CAMK2B KCNK9 KCNK9 MC2R MC2R NPR1 NPR1 ATP2B2 ATP2B2 SCARB1 SCARB1 CACNA1F CACNA1F ORAI1 ORAI1 ARSI ARSI ITPR3 ITPR3 POMC POMC H0WB32_CAVPO H0WB32_CAVPO CACNA1G CACNA1G AGT AGT LDLR LDLR CACNA1S CACNA1S CREB1 CREB1 PLCB3 PLCB3 GNA11 GNA11 LOC100732158 LOC100732158 LIPE LIPE ATP2B1 ATP2B1 CAMK2G CAMK2G CACNA1C CACNA1C PLCB1 PLCB1 ATP2B4 ATP2B4 CALML4 CALML4 ATP1A4 ATP1A4 PRKCG PRKCG CAMK1D CAMK1D ATP1B2 ATP1B2 ATP1B4 ATP1B4 ADCY9 ADCY9 ATP1A1 ATP1A1 PRKACB PRKACB GNAQ GNAQ PDE2A PDE2A KCNJ5 KCNJ5 ATF6B ATF6B ADCY6 ADCY6 ADCY7 ADCY7 CALM3 CALM3 ATP1B1 ATP1B1 LOC100725531 LOC100725531 PLCB4 PLCB4 ATP1A2 ATP1A2 PLCB2 PLCB2 CREB3L4 CREB3L4 ITPR1 ITPR1 Camk2d Camk2d ATF1 ATF1 ATP2B3 ATP2B3 ATF2 ATF2 LOC100732436 LOC100732436 ENSCPOP00000032059 ENSCPOP00000032059 CACNA1D CACNA1D Prkaca Prkaca Hsd3b1 Hsd3b1 CALM2 CALM2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
ADCY1Adenylate cyclase 1. (944 aa)
LOC100727788Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (865 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (478 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
LOC100716515Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (522 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (359 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
LOC1007258013Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
DAGLADiacylglycerol lipase alpha. (1037 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
ATF4Activating transcription factor 4. (354 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
KCNK3Potassium two pore domain channel subfamily K member 3. (270 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
KCNK9Potassium channel subfamily K member 9; pH-dependent, voltage-insensitive, background potassium channel protein; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (365 aa)
MC2RAdrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). (297 aa)
NPR1Guanylate cyclase. (881 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
ARSIArylsulfatase family member I. (572 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
H0WB32_CAVPOSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (177 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
LDLRLow density lipoprotein receptor. (807 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
LOC100732158Uncharacterized protein. (246 aa)
LIPELipase E, hormone sensitive type. (802 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CALML4Calmodulin like 4. (153 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (381 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
PDE2APhosphodiesterase. (950 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ATF6BActivating transcription factor 6 beta. (694 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
CALM3Calmodulin 3. (149 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
LOC1007255313Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (353 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ATF1Activating transcription factor 1. (269 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1226 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC100732436Uncharacterized protein. (327 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Hsd3b13beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase; Belongs to the 3-beta-HSD family. (373 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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