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| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (659 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | KCNK2 | Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | Prkaca | Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa) |
| | ENSCPOP00000032922 | Uncharacterized protein. (109 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | CTNNB1 | Catenin beta 1. (781 aa) |
| | Rap1b | Uncharacterized protein. (184 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (738 aa) |
| | LOC100732436 | Uncharacterized protein. (327 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | ENSCPOP00000030705 | CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa) |
| | Camk2d | Protein kinase domain-containing protein. (532 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (388 aa) |
| | CRH | Corticotropin releasing hormone. (193 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (505 aa) |
| | GNAI1 | Uncharacterized protein. (330 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa) |
| | CRHR2 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (436 aa) |
| | PDE8A | Phosphodiesterase. (826 aa) |
| | Rbbp5 | WD_REPEATS_REGION domain-containing protein. (149 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | ENSCPOP00000028762 | Uncharacterized protein. (107 aa) |
| | NCEH1 | Neutral cholesterol ester hydrolase 1. (408 aa) |
| | KCNA2 | Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa) |
| | LOC100725531 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (353 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa) |
| | KCNA4 | Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (622 aa) |
| | WDR5 | WD repeat domain 5. (334 aa) |
| | E2F3 | E2F transcription factor 3. (457 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | AIPL1 | Aryl hydrocarbon receptor interacting protein like 1. (328 aa) |
| | ATF6B | Activating transcription factor 6 beta. (694 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | ASH2L | ASH2 like, histone lysine methyltransferase complex subunit. (629 aa) |
| | GNAQ | G protein subunit alpha q. (313 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | E2F1 | E2F transcription factor 1. (389 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (169 aa) |
| | ENSCPOP00000025354 | WD_REPEATS_REGION domain-containing protein. (312 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (396 aa) |
| | LOC100713271 | Uncharacterized protein. (165 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | RASD1 | Ras related dexamethasone induced 1. (280 aa) |
| | CACNA1C | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa) |
| | CAMK2G | Calcium/calmodulin dependent protein kinase II gamma. (545 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (717 aa) |
| | FH | Fumarate hydratase. (508 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (350 aa) |
| | LOC100732158 | Uncharacterized protein. (246 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa) |
| | GNA11 | G protein subunit alpha 11. (345 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | CACNA1S | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa) |
| | LDLR | Low density lipoprotein receptor. (807 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (477 aa) |
| | TCF7 | Transcription factor 7. (262 aa) |
| | CACNA1G | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa) |
| | Wdr5b | WD_REPEATS_REGION domain-containing protein. (324 aa) |
| | POMC | Corticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2086 aa) |
| | KCNA5 | Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (609 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | ARSI | Arylsulfatase family member I. (572 aa) |
| | Cyp11b2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (479 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (737 aa) |
| | ORAI1 | ORAI calcium release-activated calcium modulator 1. (302 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa) |
| | CACNA1F | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | MC2R | Adrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). (297 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (134 aa) |
| | AIP | Aryl hydrocarbon receptor interacting protein. (330 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa) |
| | H0VX85_CAVPO | Uncharacterized protein. (184 aa) |
| | KCNK3 | Potassium two pore domain channel subfamily K member 3. (270 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa) |
| | KCNA3 | Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (528 aa) |
| | ATF4 | Activating transcription factor 4. (354 aa) |
| | NR5A1 | Nuclear receptor subfamily 5 group A member 1. (457 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa) |
| | Arnt | Uncharacterized protein. (775 aa) |
| | CYP17A1 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (499 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (587 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa) |
| | CYP11B1 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (409 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa) |
| | Ccne2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (325 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa) |
| | CACNA1H | Calcium voltage-gated channel subunit alpha1 H. (2337 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa) |
| | CACNA1I | Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa) |
| | AXIN1 | Axin 1. (863 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa) |
| | ARMC5 | Armadillo repeat containing 5. (905 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (419 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (522 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | H0VE70_CAVPO | Uncharacterized protein. (796 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | E2F2 | E2F transcription factor 2. (431 aa) |
| | RB1 | RB transcriptional corepressor 1. (840 aa) |
| | LOC100725801 | 3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (698 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa) |
| | PBX1 | PBX homeobox 1. (430 aa) |
| | Kmt2a | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2938 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) |
| | PTRHD1 | Peptidyl-tRNA hydrolase domain containing 1. (140 aa) |
| | H0V5P5_CAVPO | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa) |
| | Ahr | Uncharacterized protein. (832 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | KCNA1 | Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa) |
| | AXIN2 | Axin 2. (802 aa) |
| | STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (598 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | KMT2D | Lysine methyltransferase 2D. (5430 aa) |
| | LOC100727788 | Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa) |
| | ADCY1 | Adenylate cyclase 1. (944 aa) |
| | USP8 | Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa) |
| | KCNA10 | Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa) |
| | APC | APC regulator of WNT signaling pathway. (2842 aa) |
| | MEN1 | Menin 1. (615 aa) |
| | Hsd3b1 | 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase; Belongs to the 3-beta-HSD family. (373 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (131 aa) |
| | Pde8b | Phosphodiesterase. (785 aa) |
| | Pde11a | Phosphodiesterase. (888 aa) |
| | LOC100716515 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (522 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (384 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
