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MAOA MAOA GRIA2 GRIA2 CREB3 CREB3 MAOB MAOB GRIN2C GRIN2C SLC18A1 SLC18A1 SLC18A2 SLC18A2 DDC DDC GRM2 GRM2 GRIN2B GRIN2B NFKB1 NFKB1 CREB3L2 CREB3L2 PPP1R1B PPP1R1B H0VE70_CAVPO H0VE70_CAVPO DRD2 DRD2 CREB3L1 CREB3L1 CREB3L3 CREB3L3 RGS11 RGS11 GNAI3 GNAI3 GRIN3B GRIN3B TH TH RGS9 RGS9 GRIN2A GRIN2A CREB5 CREB5 GRM3 GRM3 ADCY5 ADCY5 FOSB FOSB ATF4 ATF4 GPSM1 GPSM1 CDK5R1 CDK5R1 RELA RELA PDYN PDYN DLG4 DLG4 SLC6A3 SLC6A3 JUN JUN CREB1 CREB1 LOC100732158 LOC100732158 DRD1 DRD1 GNAI2 GNAI2 GRIN1 GRIN1 PRKACB PRKACB ATF6B ATF6B GRIN2D GRIN2D GNAI1 GNAI1 CREB3L4 CREB3L4 BDNF BDNF ATF2 ATF2 Cdk5r2 Cdk5r2 LOC100732436 LOC100732436 CDK5 CDK5 Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAOAAmine oxidase. (461 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
CREB3cAMP responsive element binding protein 3. (384 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (520 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
SLC18A2Solute carrier family 18 member A2. (516 aa)
DDCAromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (480 aa)
GRM2Glutamate metabotropic receptor 2. (871 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (184 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (522 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (419 aa)
RGS11Regulator of G protein signaling 11. (466 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (845 aa)
THTyrosine hydroxylase. (498 aa)
RGS9Regulator of G protein signaling 9. (680 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
GRM3Glutamate metabotropic receptor 3. (877 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (340 aa)
ATF4Activating transcription factor 4. (354 aa)
GPSM1G protein signaling modulator 1. (706 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (245 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LOC100732158Uncharacterized protein. (246 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ATF6BActivating transcription factor 6 beta. (694 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
GNAI1Uncharacterized protein. (330 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (388 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (289 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
Cdk5r2Uncharacterized protein. (97 aa)
LOC100732436Uncharacterized protein. (327 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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