70 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	CAMK2G	Calcium/calmodulin dependent protein kinase II gamma. (545 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	LOC100732158	Uncharacterized protein. (246 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
	PDYN	Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (245 aa)
	ARC	Activity regulated cytoskeleton associated protein. (395 aa)
	ARSI	Arylsulfatase family member I. (572 aa)
	CAMK2B	Calcium/calmodulin dependent protein kinase II beta. (659 aa)
	ATF4	Activating transcription factor 4. (354 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
	FOSB	FosB proto-oncogene, AP-1 transcription factor subunit. (340 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	CREB3	cAMP responsive element binding protein 3. (384 aa)
	SIRT1	Sirtuin 1. (717 aa)
	MAOB	Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (520 aa)
	MAOA	Amine oxidase. (461 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (481 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
	CALM2	Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
	SLC18A1	Solute carrier family 18 member A1. (525 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (194 aa)
	STX1A	Syntaxin 1A; Belongs to the syntaxin family. (288 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
	SLC18A2	Solute carrier family 18 member A2. (516 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
	DDC	Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (480 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV. (418 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (531 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (520 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (184 aa)
	H0VE70_CAVPO	Uncharacterized protein. (796 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (518 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (522 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (419 aa)
	GRIN3B	Glutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (845 aa)
	H0VKV0_CAVPO	Uncharacterized protein; Belongs to the calmodulin family. (139 aa)
	TH	Tyrosine hydroxylase. (498 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
	Prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
	ENSCPOP00000032059	Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
	PPP3R1	Uncharacterized protein. (169 aa)
	LOC100732436	Uncharacterized protein. (327 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	Camk2d	Protein kinase domain-containing protein. (532 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (388 aa)
	CALM3	Calmodulin 3. (149 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
	ATF6B	Activating transcription factor 6 beta. (694 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	GRIN1	Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	CALML4	Calmodulin like 4. (153 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CALM1	ENSCPOP00000012551	ENSCPOP00000002216	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.627
ADCY5	CALM2	ENSCPOP00000012551	ENSCPOP00000001454	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin isoform 3; Belongs to the calmodulin family.	0.627
ADCY5	CALM3	ENSCPOP00000012551	ENSCPOP00000027832	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3.	0.627
ADCY5	CALML3	ENSCPOP00000012551	ENSCPOP00000012869	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.751
ADCY5	CALML4	ENSCPOP00000012551	ENSCPOP00000023763	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.816
ADCY5	CAMK2A	ENSCPOP00000012551	ENSCPOP00000005978	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.916
ADCY5	CAMK2B	ENSCPOP00000012551	ENSCPOP00000016795	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II beta.	0.797
ADCY5	CAMK2G	ENSCPOP00000012551	ENSCPOP00000022960	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II gamma.	0.704
ADCY5	CAMK4	ENSCPOP00000012551	ENSCPOP00000006398	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase IV.	0.909
ADCY5	Camk2d	ENSCPOP00000012551	ENSCPOP00000030575	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.797
ADCY5	DDC	ENSCPOP00000012551	ENSCPOP00000004824	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family.	0.462
ADCY5	ENSCPOP00000032059	ENSCPOP00000012551	ENSCPOP00000032059	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.627
ADCY5	H0VE70_CAVPO	ENSCPOP00000012551	ENSCPOP00000008303	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.906
ADCY5	H0VKV0_CAVPO	ENSCPOP00000012551	ENSCPOP00000010954	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.627
ADCY5	LOC100732158	ENSCPOP00000012551	ENSCPOP00000021644	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.796
ADCY5	LOC100732436	ENSCPOP00000012551	ENSCPOP00000031430	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.973
ADCY5	PRKACB	ENSCPOP00000012551	ENSCPOP00000026584	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.961
ADCY5	PRKCA	ENSCPOP00000012551	ENSCPOP00000013427	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.748
ADCY5	PRKCB	ENSCPOP00000012551	ENSCPOP00000003120	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.924
ADCY5	PRKCG	ENSCPOP00000012551	ENSCPOP00000024351	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.919