STRINGSTRING
FOS FOS PLCB3 PLCB3 JUN JUN BDKRB2 BDKRB2 IKBKG IKBKG TLR2 TLR2 MYD88 MYD88 CD3G CD3G LOC100714182 LOC100714182 H0W5Z7_CAVPO H0W5Z7_CAVPO LOC100735910 LOC100735910 H0W538_CAVPO H0W538_CAVPO C3 C3 NOS2 NOS2 H0W160_CAVPO H0W160_CAVPO H0W0D3_CAVPO H0W0D3_CAVPO H0W027_CAVPO H0W027_CAVPO RELA RELA LOC100734449 LOC100734449 H0VX22_CAVPO H0VX22_CAVPO H0VWU3_CAVPO H0VWU3_CAVPO LOC100712658 LOC100712658 CASP10 CASP10 PPP2R2A PPP2R2A AKT3 AKT3 TLR4 TLR4 TGFBR1 TGFBR1 MAPK12 MAPK12 MAPK13 MAPK13 MAP2K4 MAP2K4 LOC100721360 LOC100721360 CCL2 CCL2 SMAD2 SMAD2 CD3D CD3D MAPK1 MAPK1 IFNGR1 IFNGR1 PIK3CD PIK3CD KNG1 KNG1 GNAI3 GNAI3 FADD FADD IFNG IFNG H0VH94_CAVPO H0VH94_CAVPO IKBKB IKBKB Ifnb1 Ifnb1 IFNGR2 IFNGR2 H0VE70_CAVPO H0VE70_CAVPO CCL5 CCL5 LOC100734047 LOC100734047 IL2 IL2 C1QB C1QB LOC100732158 LOC100732158 PIK3R1 PIK3R1 NFKB1 NFKB1 TGFB2 TGFB2 PIK3CA PIK3CA NFKBIA NFKBIA GNA14 GNA14 PPP2CB PPP2CB TLR6 TLR6 Gna15 Gna15 TRAF6 TRAF6 AADAC AADAC GNA11 GNA11 CXCL8 CXCL8 PPP2R2D PPP2R2D MAPK14 MAPK14 PLCB1 PLCB1 SERPINE1 SERPINE1 ENSCPOP00000024109 ENSCPOP00000024109 MAPK11 MAPK11 MAPK3 MAPK3 PPP2CA PPP2CA MAPK8 MAPK8 PPP2R1B PPP2R1B GNAO1 GNAO1 MAPK9 MAPK9 GNAI2 GNAI2 LOC100724130 LOC100724130 TRBV24-1 TRBV24-1 AKT1 AKT1 TRBV19 TRBV19 TGFBR2 TGFBR2 LOC100717552 LOC100717552 GNAQ GNAQ LOC106027640 LOC106027640 TGFB3 TGFB3 ENSCPOP00000028279 ENSCPOP00000028279 ENSCPOP00000028400 ENSCPOP00000028400 TNFRSF1A TNFRSF1A ENSCPOP00000029012 ENSCPOP00000029012 PLCB4 PLCB4 PLCB2 PLCB2 ENSCPOP00000029477 ENSCPOP00000029477 CD247 CD247 GNAI1 GNAI1 LOC100734206 LOC100734206 CASP8 CASP8 LOC100735187 LOC100735187 AADACL2 AADACL2 PPP2R2C PPP2R2C FAS FAS LOC100732436 LOC100732436 PPP2R2B PPP2R2B GNAL GNAL ADCY1 ADCY1 TNF TNF IL1B IL1B IRAK4 IRAK4 IL12B IL12B ACE ACE CD3E CD3E TGFB1 TGFB1 PIK3CB PIK3CB CALR CALR CFLAR CFLAR Il12a Il12a Faslg Faslg AKT2 AKT2 C1QA C1QA C1QC C1QC CHUK CHUK IRAK1 IRAK1 ENSCPOP00000032616 ENSCPOP00000032616 MAPK10 MAPK10 IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
BDKRB2B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (399 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
CD3GCD3g molecule. (181 aa)
LOC100714182Angiotensin-converting enzyme. (701 aa)
H0W5Z7_CAVPOAngiotensin-converting enzyme. (622 aa)
LOC100735910Angiotensin-converting enzyme. (706 aa)
H0W538_CAVPOUncharacterized protein. (315 aa)
C3Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (912 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1149 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
H0W0D3_CAVPOIg-like domain-containing protein. (126 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
LOC100734449Uncharacterized protein. (183 aa)
H0VX22_CAVPOC-C motif chemokine. (93 aa)
H0VWU3_CAVPOAngiotensin-converting enzyme. (685 aa)
LOC100712658Angiotensin-converting enzyme. (718 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
LOC100721360Uncharacterized protein. (401 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (120 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CD3DCD3d molecule. (171 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
IFNGR1Interferon gamma receptor 1. (465 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
KNG1Kininogen 1. (625 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
H0VH94_CAVPOIg-like domain-containing protein. (123 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
Ifnb1Uncharacterized protein. (189 aa)
IFNGR2Interferon gamma receptor 2. (350 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
LOC100734047Uncharacterized protein. (567 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
C1QBComplement C1q B chain. (251 aa)
LOC100732158Uncharacterized protein. (246 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
GNA14G protein subunit alpha 14. (356 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
Gna15Uncharacterized protein. (205 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
AADACArylacetamide deacetylase. (353 aa)
GNA11G protein subunit alpha 11. (345 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (476 aa)
ENSCPOP00000024109DUF1968 domain-containing protein. (138 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
GNAO1G protein subunit alpha o1. (318 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
LOC100724130TIR domain-containing protein. (1029 aa)
TRBV24-1T cell receptor beta variable 24-1. (133 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC100717552C-C motif chemokine. (120 aa)
GNAQG protein subunit alpha q. (313 aa)
LOC106027640C-C motif chemokine. (97 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSCPOP00000028279Ig-like domain-containing protein. (134 aa)
ENSCPOP00000028400Ig-like domain-containing protein. (116 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
ENSCPOP00000029012Uncharacterized protein. (138 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSCPOP00000029477Ig-like domain-containing protein. (137 aa)
CD247CD247 molecule. (164 aa)
GNAI1Uncharacterized protein. (330 aa)
LOC100734206Uncharacterized protein. (461 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
LOC100735187C-C motif chemokine. (93 aa)
AADACL2Arylacetamide deacetylase like 2. (401 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (461 aa)
FASFas cell surface death receptor. (334 aa)
LOC100732436Uncharacterized protein. (327 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
GNALG protein subunit alpha L. (372 aa)
ADCY1Adenylate cyclase 1. (944 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (462 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa)
ACEAngiotensin-converting enzyme. (1302 aa)
CD3ECD3e molecule. (194 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
CALRCalreticulin. (417 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
C1QAComplement C1q A chain. (244 aa)
C1QCComplement C1q C chain. (246 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
ENSCPOP00000032616Ig-like domain-containing protein. (125 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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