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| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (399 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa) |
| | TLR2 | Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa) |
| | CD3G | CD3g molecule. (181 aa) |
| | LOC100714182 | Angiotensin-converting enzyme. (701 aa) |
| | H0W5Z7_CAVPO | Angiotensin-converting enzyme. (622 aa) |
| | LOC100735910 | Angiotensin-converting enzyme. (706 aa) |
| | H0W538_CAVPO | Uncharacterized protein. (315 aa) |
| | C3 | Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. (912 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1149 aa) |
| | H0W160_CAVPO | Uncharacterized protein. (589 aa) |
| | H0W0D3_CAVPO | Ig-like domain-containing protein. (126 aa) |
| | H0W027_CAVPO | Uncharacterized protein. (722 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (549 aa) |
| | LOC100734449 | Uncharacterized protein. (183 aa) |
| | H0VX22_CAVPO | C-C motif chemokine. (93 aa) |
| | H0VWU3_CAVPO | Angiotensin-converting enzyme. (685 aa) |
| | LOC100712658 | Angiotensin-converting enzyme. (718 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (474 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa) |
| | AKT3 | AKT serine/threonine kinase 3. (470 aa) |
| | TLR4 | Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa) |
| | LOC100721360 | Uncharacterized protein. (401 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (120 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | CD3D | CD3d molecule. (171 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (325 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (465 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa) |
| | KNG1 | Kininogen 1. (625 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa) |
| | H0VH94_CAVPO | Ig-like domain-containing protein. (123 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (739 aa) |
| | Ifnb1 | Uncharacterized protein. (189 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (350 aa) |
| | H0VE70_CAVPO | Uncharacterized protein. (796 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | LOC100734047 | Uncharacterized protein. (567 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa) |
| | C1QB | Complement C1q B chain. (251 aa) |
| | LOC100732158 | Uncharacterized protein. (246 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (967 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa) |
| | PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | GNA14 | G protein subunit alpha 14. (356 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (308 aa) |
| | TLR6 | Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa) |
| | Gna15 | Uncharacterized protein. (205 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa) |
| | AADAC | Arylacetamide deacetylase. (353 aa) |
| | GNA11 | G protein subunit alpha 11. (345 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa) |
| | SERPINE1 | Serpin family E member 1; Belongs to the serpin family. (476 aa) |
| | ENSCPOP00000024109 | DUF1968 domain-containing protein. (138 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (385 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (696 aa) |
| | GNAO1 | G protein subunit alpha o1. (318 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa) |
| | LOC100724130 | TIR domain-containing protein. (1029 aa) |
| | TRBV24-1 | T cell receptor beta variable 24-1. (133 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | TRBV19 | T cell receptor beta variable 19. (129 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa) |
| | LOC100717552 | C-C motif chemokine. (120 aa) |
| | GNAQ | G protein subunit alpha q. (313 aa) |
| | LOC106027640 | C-C motif chemokine. (97 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | ENSCPOP00000028279 | Ig-like domain-containing protein. (134 aa) |
| | ENSCPOP00000028400 | Ig-like domain-containing protein. (116 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (469 aa) |
| | ENSCPOP00000029012 | Uncharacterized protein. (138 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa) |
| | ENSCPOP00000029477 | Ig-like domain-containing protein. (137 aa) |
| | CD247 | CD247 molecule. (164 aa) |
| | GNAI1 | Uncharacterized protein. (330 aa) |
| | LOC100734206 | Uncharacterized protein. (461 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (481 aa) |
| | LOC100735187 | C-C motif chemokine. (93 aa) |
| | AADACL2 | Arylacetamide deacetylase like 2. (401 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (461 aa) |
| | FAS | Fas cell surface death receptor. (334 aa) |
| | LOC100732436 | Uncharacterized protein. (327 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa) |
| | GNAL | G protein subunit alpha L. (372 aa) |
| | ADCY1 | Adenylate cyclase 1. (944 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (462 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa) |
| | ACE | Angiotensin-converting enzyme. (1302 aa) |
| | CD3E | CD3e molecule. (194 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa) |
| | CALR | Calreticulin. (417 aa) |
| | CFLAR | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa) |
| | Il12a | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa) |
| | Faslg | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | C1QA | Complement C1q A chain. (244 aa) |
| | C1QC | Complement C1q C chain. (246 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (749 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (707 aa) |
| | ENSCPOP00000032616 | Ig-like domain-containing protein. (125 aa) |
| | MAPK10 | Mitogen-activated protein kinase 10. (434 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
