STRINGSTRING
ACTN4 ACTN4 Il12a Il12a COL4A4 COL4A4 PIK3CB PIK3CB PTK2 PTK2 TGFB1 TGFB1 IL12B IL12B IL1B IL1B SERPINB13 SERPINB13 CD1B1 CD1B1 TNF TNF ADCY1 ADCY1 ARG2 ARG2 C8G C8G GNAL GNAL COL1A1 COL1A1 PRKCB PRKCB LAMB3 LAMB3 LAMC3 LAMC3 Gna15 Gna15 RAB5A RAB5A GNA14 GNA14 H0V789_CAVPO H0V789_CAVPO LAMA4 LAMA4 PIK3CA PIK3CA COL3A1 COL3A1 LAMA3 LAMA3 CD1C1 CD1C1 TGFB2 TGFB2 NFKB1 NFKB1 PIK3R1 PIK3R1 CD1E CD1E LAMC1 LAMC1 LAMC2 LAMC2 SERPINB6 SERPINB6 H0VE70_CAVPO H0VE70_CAVPO LAMA5 LAMA5 LAMB2 LAMB2 COL4A2 COL4A2 COL1A2 COL1A2 LOC100735393 LOC100735393 IFNG IFNG Rab5c Rab5c LOC100733338 LOC100733338 Casp3 Casp3 FN1 FN1 PIK3CD PIK3CD LAMA1 LAMA1 TRANK1 TRANK1 H0VPL6_CAVPO H0VPL6_CAVPO CD1D CD1D LAMA2 LAMA2 H0VR18_CAVPO H0VR18_CAVPO PRKCA PRKCA COL4A6 COL4A6 RAB17 RAB17 TLR4 TLR4 COL4A1 COL4A1 ITGB2 ITGB2 SMTNL2 SMTNL2 CSF2 CSF2 H0VZI8_CAVPO H0VZI8_CAVPO RELA RELA H0W027_CAVPO H0W027_CAVPO CD1B4 CD1B4 NOS2 NOS2 LOC101788748 LOC101788748 PRDX2 PRDX2 LOC100722742 LOC100722742 H0W557_CAVPO H0W557_CAVPO H0W6K2_CAVPO H0W6K2_CAVPO LOC100719765 LOC100719765 CD14 CD14 TLR2 TLR2 H0WAH0_CAVPO H0WAH0_CAVPO H0WAR2_CAVPO H0WAR2_CAVPO LOC100720328 LOC100720328 CD1B3 CD1B3 CD1B2 CD1B2 LOC100717646 LOC100717646 LOC100720047 LOC100720047 H0WDE0_CAVPO H0WDE0_CAVPO ARG1 ARG1 LOC100721094 LOC100721094 PLCB3 PLCB3 GNA11 GNA11 LOC100732158 LOC100732158 RAB5B RAB5B LAMB1 LAMB1 CXCL8 CXCL8 ENSCPOP00000022167 ENSCPOP00000022167 ENSCPOP00000022622 ENSCPOP00000022622 ENSCPOP00000022635 ENSCPOP00000022635 LOC100731921 LOC100731921 C8B C8B LOC100734890 LOC100734890 ENSCPOP00000023408 ENSCPOP00000023408 PLCB1 PLCB1 ENSCPOP00000023578 ENSCPOP00000023578 LOC100733491 LOC100733491 ENSCPOP00000023636 ENSCPOP00000023636 ENSCPOP00000023778 ENSCPOP00000023778 ENSCPOP00000023913 ENSCPOP00000023913 H0VVB6_CAVPO H0VVB6_CAVPO PRKCG PRKCG Specc1l Specc1l LOC100721702 LOC100721702 ENSCPOP00000025410 ENSCPOP00000025410 SMTN SMTN ENSCPOP00000025793 ENSCPOP00000025793 RAB7B RAB7B ITGAM ITGAM ENSCPOP00000026228 ENSCPOP00000026228 CD1C3 CD1C3 SERPINB8 SERPINB8 PRKACB PRKACB GNAQ GNAQ LOC100733619 LOC100733619 DCLK2 DCLK2 TGFB3 TGFB3 ENSCPOP00000027199 ENSCPOP00000027199 PRDX1 PRDX1 ACTN1 ACTN1 ENSCPOP00000028856 ENSCPOP00000028856 ENSCPOP00000028990 ENSCPOP00000028990 PLCB4 PLCB4 ENSCPOP00000029145 ENSCPOP00000029145 PLCB2 PLCB2 ENSCPOP00000029468 ENSCPOP00000029468 ENSCPOP00000029769 ENSCPOP00000029769 CXCL1 CXCL1 LOC100734206 LOC100734206 VCL VCL CD1C2 CD1C2 C6 C6 IL1R1 IL1R1 ENSCPOP00000030754 ENSCPOP00000030754 ENSCPOP00000030758 ENSCPOP00000030758 ENSCPOP00000031130 ENSCPOP00000031130 SMTNL1 SMTNL1 ENSCPOP00000031332 ENSCPOP00000031332 SPECC1 SPECC1 LOC100732436 LOC100732436 MFF MFF ENSCPOP00000031748 ENSCPOP00000031748 LOC100720650 LOC100720650 ENSCPOP00000032517 ENSCPOP00000032517 HSPB1 HSPB1 IL1R2 IL1R2 C8A C8A RAB7A RAB7A Prkaca Prkaca IL10 IL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN4Actinin alpha 4. (911 aa)
Il12aInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa)
COL4A4Collagen type IV alpha 4 chain. (1686 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
SERPINB13Serpin family B member 13; Belongs to the serpin family. (390 aa)
CD1B1T-cell surface glycoprotein CD1b1; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (333 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ADCY1Adenylate cyclase 1. (944 aa)
ARG2Arginase. (354 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
GNALG protein subunit alpha L. (372 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
LAMB3Laminin subunit beta 3. (1174 aa)
LAMC3Laminin subunit gamma 3. (1491 aa)
Gna15Uncharacterized protein. (205 aa)
RAB5ARAB5A, member RAS oncogene family. (214 aa)
GNA14G protein subunit alpha 14. (356 aa)
H0V789_CAVPOIg-like domain-containing protein. (126 aa)
LAMA4Laminin subunit alpha 4. (1810 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
LAMA3Laminin subunit alpha 3. (3262 aa)
CD1C1T-cell surface glycoprotein CD1c1; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (332 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CD1ET-cell surface glycoprotein CD1e, membrane-associated; T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active (By similarity). (391 aa)
LAMC1Laminin subunit gamma 1. (1557 aa)
LAMC2Laminin subunit gamma 2. (1189 aa)
SERPINB6Serpin B6; Belongs to the serpin family. (378 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
LAMA5Laminin subunit alpha 5. (3609 aa)
LAMB2Laminin subunit beta 2. (1800 aa)
COL4A2Collagen type IV alpha 2 chain. (1479 aa)
COL1A2Collagen type I alpha 2 chain. (1287 aa)
LOC100735393SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
Rab5cUncharacterized protein. (216 aa)
LOC100733338Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
FN1Fibronectin 1. (2478 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
LAMA1Laminin subunit alpha 1. (3018 aa)
TRANK1Tetratricopeptide repeat and ankyrin repeat containing 1. (2905 aa)
H0VPL6_CAVPOSERPIN domain-containing protein; Belongs to the serpin family. (383 aa)
CD1DIg-like domain-containing protein. (335 aa)
LAMA2Laminin subunit alpha 2. (3113 aa)
H0VR18_CAVPOIg-like domain-containing protein. (136 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
COL4A6Collagen type IV alpha 6 chain. (1687 aa)
RAB17RAB17, member RAS oncogene family. (208 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
COL4A1Collagen type IV alpha 1 chain. (1658 aa)
ITGB2Integrin beta. (767 aa)
SMTNL2Smoothelin like 2. (438 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (145 aa)
H0VZI8_CAVPOIg-like domain-containing protein. (123 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CD1B4T-cell surface glycoprotein CD1b4; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (330 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1149 aa)
LOC101788748Uncharacterized protein. (478 aa)
PRDX2Peroxiredoxin 2. (198 aa)
LOC100722742SERPIN domain-containing protein; Belongs to the serpin family. (320 aa)
H0W557_CAVPOSERPIN domain-containing protein; Belongs to the serpin family. (380 aa)
H0W6K2_CAVPOIg-like domain-containing protein. (135 aa)
LOC100719765Ig-like domain-containing protein. (330 aa)
CD14CD14 molecule. (395 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
H0WAH0_CAVPOIg-like domain-containing protein. (121 aa)
H0WAR2_CAVPOIg-like domain-containing protein. (139 aa)
LOC100720328Ig-like domain-containing protein. (333 aa)
CD1B3T-cell surface glycoprotein CD1b3; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (332 aa)
CD1B2T-cell surface glycoprotein CD1b2; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (326 aa)
LOC100717646SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
LOC100720047Ig-like domain-containing protein. (332 aa)
H0WDE0_CAVPOIg-like domain-containing protein. (118 aa)
ARG1Arginase. (322 aa)
LOC100721094SERPIN domain-containing protein; Belongs to the serpin family. (376 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
LOC100732158Uncharacterized protein. (246 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
LAMB1Laminin subunit beta 1. (1792 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
ENSCPOP00000022167Ig-like domain-containing protein. (174 aa)
ENSCPOP00000022622Ig-like domain-containing protein. (129 aa)
ENSCPOP00000022635Uncharacterized protein. (311 aa)
LOC100731921Ig-like domain-containing protein. (332 aa)
C8BComplement C8 beta chain. (583 aa)
LOC100734890Ig-like domain-containing protein. (326 aa)
ENSCPOP00000023408SERPIN domain-containing protein; Belongs to the serpin family. (207 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
ENSCPOP00000023578Ig-like domain-containing protein. (129 aa)
LOC100733491Ig-like domain-containing protein. (332 aa)
ENSCPOP00000023636Ig-like domain-containing protein. (129 aa)
ENSCPOP00000023778Ig-like domain-containing protein. (179 aa)
ENSCPOP00000023913Ig-like domain-containing protein. (122 aa)
H0VVB6_CAVPOIg-like domain-containing protein. (137 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
Specc1lCalponin-homology (CH) domain-containing protein. (1129 aa)
LOC100721702SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
ENSCPOP00000025410Ig-like domain-containing protein. (118 aa)
SMTNSmoothelin. (919 aa)
ENSCPOP00000025793Ig-like domain-containing protein. (146 aa)
RAB7BRAB7B, member RAS oncogene family. (196 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
ENSCPOP00000026228Ig-like domain-containing protein. (134 aa)
CD1C3T-cell surface glycoprotein CD1c3; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (332 aa)
SERPINB8Serpin family B member 8; Belongs to the serpin family. (374 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
LOC100733619Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (258 aa)
DCLK2Doublecortin like kinase 2. (756 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSCPOP00000027199Ig-like domain-containing protein. (128 aa)
PRDX1Peroxiredoxin 1. (199 aa)
ACTN1Actinin alpha 1. (914 aa)
ENSCPOP00000028856IGc1 domain-containing protein. (326 aa)
ENSCPOP00000028990Ig-like domain-containing protein. (138 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENSCPOP00000029145Ig-like domain-containing protein. (136 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
ENSCPOP00000029468Ig-like domain-containing protein. (122 aa)
ENSCPOP00000029769Ig-like domain-containing protein. (139 aa)
CXCL1Growth-regulated alpha protein; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (118 aa)
LOC100734206Uncharacterized protein. (461 aa)
VCLVinculin. (1134 aa)
CD1C2T-cell surface glycoprotein CD1c2; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (332 aa)
C6Complement C6. (919 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
ENSCPOP00000030754Ig-like domain-containing protein. (139 aa)
ENSCPOP00000030758Ig-like domain-containing protein. (122 aa)
ENSCPOP00000031130Ig-like domain-containing protein. (136 aa)
SMTNL1Smoothelin like 1. (503 aa)
ENSCPOP00000031332Ig-like domain-containing protein. (138 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1058 aa)
LOC100732436Uncharacterized protein. (327 aa)
MFFMitochondrial fission factor. (354 aa)
ENSCPOP00000031748Ig-like domain-containing protein. (136 aa)
LOC100720650SERPIN domain-containing protein; Belongs to the serpin family. (375 aa)
ENSCPOP00000032517Ig-like domain-containing protein. (129 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
IL1R2Interleukin 1 receptor type 2. (440 aa)
C8AComplement C8 alpha chain. (588 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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