STRINGSTRING
BCL2L1 BCL2L1 MAPK10 MAPK10 HRAS HRAS ENSCPOP00000032616 ENSCPOP00000032616 IRAK1 IRAK1 ENSCPOP00000032059 ENSCPOP00000032059 CHUK CHUK PPP3R1 PPP3R1 LOC100715212 LOC100715212 CSDE1 CSDE1 BAX BAX LOC100731649 LOC100731649 AKT2 AKT2 ENSCPOP00000031524 ENSCPOP00000031524 Faslg Faslg LOC100716672 LOC100716672 GNGT2 GNGT2 AP1M2 AP1M2 FBXW11 FBXW11 Ccnb1 Ccnb1 FAS FAS ENSCPOP00000030888 ENSCPOP00000030888 ELOC ELOC ITPR1 ITPR1 ENSCPOP00000030509 ENSCPOP00000030509 PTK2B PTK2B STING1 STING1 CASP8 CASP8 LOC100724988 LOC100724988 LOC100734206 LOC100734206 GNAI1 GNAI1 CFL2 CFL2 CD247 CD247 ENSCPOP00000029477 ENSCPOP00000029477 GNG4 GNG4 ENSCPOP00000029251 ENSCPOP00000029251 ENSCPOP00000029129 ENSCPOP00000029129 AP1B1 AP1B1 ENSCPOP00000029012 ENSCPOP00000029012 TNFRSF1A TNFRSF1A LOC100724240 LOC100724240 AP1S3 AP1S3 ENSCPOP00000028400 ENSCPOP00000028400 ENSCPOP00000028279 ENSCPOP00000028279 ENSCPOP00000027951 ENSCPOP00000027951 CRKL CRKL CALM3 CALM3 GNG8 GNG8 ENSCPOP00000027611 ENSCPOP00000027611 DDB1 DDB1 LOC100733898 LOC100733898 CXCR4 CXCR4 CUL5 CUL5 TRIM6 TRIM6 GNAQ GNAQ Gng5 Gng5 TRBV19 TRBV19 TRAF2 TRAF2 GNG12 GNG12 AKT1 AKT1 TRBV24-1 TRBV24-1 AP1G1 AP1G1 ENSCPOP00000025873 ENSCPOP00000025873 ENSCPOP00000025638 ENSCPOP00000025638 CUL4B CUL4B ENSCPOP00000025455 ENSCPOP00000025455 RBX1 RBX1 MAP3K7 MAP3K7 GNAI2 GNAI2 GNB4 GNB4 GNG11 GNG11 MAPK9 MAPK9 GNAO1 GNAO1 GNG2 GNG2 CCDC194 CCDC194 MAPK8 MAPK8 PRKCG PRKCG RNF7 RNF7 MAPK3 MAPK3 MAPK11 MAPK11 ENSCPOP00000024144 ENSCPOP00000024144 ENSCPOP00000024109 ENSCPOP00000024109 ENSCPOP00000023919 ENSCPOP00000023919 PAK3 PAK3 RPS6KB2 RPS6KB2 CALML4 CALML4 B2M B2M NFATC3 NFATC3 GNG7 GNG7 Ccnb3 Ccnb3 PAK2 PAK2 MAPK14 MAPK14 GNG3 GNG3 RAC1 RAC1 MAP2K6 MAP2K6 RIPK1 RIPK1 Tap2 Tap2 TRAF5 TRAF5 FOS FOS GNA11 GNA11 JUN JUN H0WBW4_CAVPO H0WBW4_CAVPO TAB1 TAB1 TAPBP TAPBP IKBKG IKBKG TLR2 TLR2 H0W9P9_CAVPO H0W9P9_CAVPO ITPR3 ITPR3 Elob Elob PAK4 PAK4 MYD88 MYD88 AP1S2 AP1S2 CD3G CD3G TNFRSF1B TNFRSF1B H0W5F0_CAVPO H0W5F0_CAVPO H0W538_CAVPO H0W538_CAVPO PAK6 PAK6 GNB3 GNB3 BCL2 BCL2 CCNB2 CCNB2 CUL1 CUL1 H0W0D3_CAVPO H0W0D3_CAVPO H0W027_CAVPO H0W027_CAVPO RELA RELA MAP2K7 MAP2K7 GNB2 GNB2 TAP1 TAP1 LOC100734449 LOC100734449 IRF3 IRF3 PLCG1 PLCG1 CCDC125 CCDC125 LOC100720222 LOC100720222 RAC2 RAC2 Chek1 Chek1 CASP10 CASP10 Wee2 Wee2 MAP2K2 MAP2K2 AKT3 AKT3 TLR4 TLR4 TAB2 TAB2 PRKCA PRKCA MAPK12 MAPK12 RPS6KB1 RPS6KB1 MAPK13 MAPK13 NFATC4 NFATC4 CALML3 CALML3 RAC3 RAC3 C7orf31 C7orf31 AP1S1 AP1S1 GNB5 GNB5 CD3D CD3D MAPK1 MAPK1 PIK3CD PIK3CD NFATC2 NFATC2 Casp3 Casp3 ITPR2 ITPR2 Cd4 Cd4 H0VKV0_CAVPO H0VKV0_CAVPO CASP9 CASP9 LPXN LPXN MTOR MTOR GNAI3 GNAI3 FADD FADD ATM ATM TBK1 TBK1 TRADD TRADD KRAS KRAS NRAS NRAS H0VH94_CAVPO H0VH94_CAVPO Cgas Cgas IKBKB IKBKB GNG13 GNG13 PPP3CA PPP3CA Ifnb1 Ifnb1 LOC101787475 LOC101787475 GNGT1 GNGT1 PDIA3 PDIA3 PPP3CB PPP3CB SAMHD1 SAMHD1 PIK3R1 PIK3R1 NFKB1 NFKB1 LOC100723960 LOC100723960 CUL4A CUL4A ATR ATR Plvap Plvap CRK CRK PIK3CA PIK3CA DCAF1 DCAF1 Bad Bad GNB1 GNB1 BTRC BTRC NFKBIA NFKBIA Cdk1 Cdk1 SKP1 SKP1 TRAF6 TRAF6 NFATC1 NFATC1 AP1M1 AP1M1 PRKCB PRKCB WEE1 WEE1 MAP2K1 MAP2K1 PPP1R14B PPP1R14B LIMK2 LIMK2 CALM1 CALM1 TNF TNF LOC100713317 LOC100713317 PLCG2 PLCG2 IRAK4 IRAK4 CALM2 CALM2 CD3E CD3E LOC100713873 LOC100713873 BAK1 BAK1 MAP2K3 MAP2K3 PAK1 PAK1 PXN PXN AP1G2 AP1G2 LIMK1 LIMK1 CALR CALR PIK3CB PIK3CB PTK2 PTK2 PPP3CC PPP3CC RAF1 RAF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BCL2L1BCL2 like 1. (233 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSCPOP00000032616Ig-like domain-containing protein. (125 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
PPP3R1Uncharacterized protein. (169 aa)
LOC100715212Uncharacterized protein. (482 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
LOC100731649Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
LOC100716672G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (449 aa)
FBXW11F-box and WD repeat domain containing 11. (530 aa)
Ccnb1annotation not available (423 aa)
FASFas cell surface death receptor. (334 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
STING1Transmembrane protein 173. (379 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
LOC100724988Uncharacterized protein. (182 aa)
LOC100734206Uncharacterized protein. (461 aa)
GNAI1Uncharacterized protein. (330 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
CD247CD247 molecule. (164 aa)
ENSCPOP00000029477Ig-like domain-containing protein. (137 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSCPOP00000029251Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
AP1B1AP complex subunit beta. (945 aa)
ENSCPOP00000029012Uncharacterized protein. (138 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
LOC100724240Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
ENSCPOP00000028400Ig-like domain-containing protein. (116 aa)
ENSCPOP00000028279Ig-like domain-containing protein. (134 aa)
ENSCPOP00000027951Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (92 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CALM3Calmodulin 3. (149 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ENSCPOP00000027611Uncharacterized protein. (421 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
LOC100733898Ig-like domain-containing protein; Belongs to the MHC class I family. (361 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
CUL5Cullin 5; Belongs to the cullin family. (820 aa)
TRIM6Tripartite motif containing 6. (488 aa)
GNAQG protein subunit alpha q. (313 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRBV24-1T cell receptor beta variable 24-1. (133 aa)
AP1G1AP-1 complex subunit gamma. (734 aa)
ENSCPOP00000025873Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (92 aa)
ENSCPOP00000025638Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CUL4BCullin 4B; Belongs to the cullin family. (936 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
RBX1Ring-box 1. (108 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
GNAO1G protein subunit alpha o1. (318 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CCDC194Coiled-coil domain containing 194. (185 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
RNF7Ring finger protein 7. (113 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
ENSCPOP00000024144Protein kinase domain-containing protein. (110 aa)
ENSCPOP00000024109DUF1968 domain-containing protein. (138 aa)
ENSCPOP00000023919Uncharacterized protein. (118 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
CALML4Calmodulin like 4. (153 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)
NFATC3Nuclear factor of activated T cells 3. (1060 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Ccnb3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1277 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (664 aa)
Tap2Uncharacterized protein. (703 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GNA11G protein subunit alpha 11. (345 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
TAPBPTAP binding protein. (436 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
H0W9P9_CAVPOWee1-like protein kinase. (551 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
ElobUbiquitin-like domain-containing protein. (118 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (294 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
CD3GCD3g molecule. (181 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
H0W5F0_CAVPOBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
H0W538_CAVPOUncharacterized protein. (315 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
GNB3G protein subunit beta 3. (340 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (398 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
H0W0D3_CAVPOIg-like domain-containing protein. (126 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (459 aa)
GNB2G protein subunit beta 2. (378 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (725 aa)
LOC100734449Uncharacterized protein. (183 aa)
IRF3Interferon regulatory factor 3. (389 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
CCDC125Coiled-coil domain containing 125. (543 aa)
LOC100720222Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
Wee2Wee1-like protein kinase. (557 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RAC3Rac family small GTPase 3. (192 aa)
C7orf31Chromosome 7 open reading frame 31. (591 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (182 aa)
GNB5G protein subunit beta 5. (406 aa)
CD3DCD3d molecule. (171 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
Cd4Uncharacterized protein. (523 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (447 aa)
LPXNLeupaxin. (381 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (206 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
TBK1TANK binding kinase 1. (729 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
H0VH94_CAVPOIg-like domain-containing protein. (123 aa)
CgasMab-21 domain-containing protein. (387 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
GNG13G protein subunit gamma 13. (67 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
Ifnb1Uncharacterized protein. (189 aa)
LOC101787475Uncharacterized protein. (410 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
LOC100723960Ig-like domain-containing protein; Belongs to the MHC class I family. (453 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
PlvapUncharacterized protein. (421 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1451 aa)
BadUncharacterized protein. (166 aa)
GNB1Beta-transducin. (340 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (438 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
WEE1Wee1-like protein kinase. (612 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (108 aa)
LIMK2LIM domain kinase 2. (637 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC100713317Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (462 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
CD3ECD3e molecule. (194 aa)
LOC100713873Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
AP1G2AP-1 complex subunit gamma. (786 aa)
LIMK1LIM domain kinase 1. (646 aa)
CALRCalreticulin. (417 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
PPP3CCSerine/threonine-protein phosphatase. (481 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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