STRINGSTRING
FGFR1 FGFR1 HCLS1 HCLS1 ACTL7A ACTL7A ERBB2 ERBB2 PPP1CC PPP1CC CTTN CTTN IGF1R IGF1R FGF2 FGF2 HIF1A HIF1A TFAP4 TFAP4 PPP1R12A PPP1R12A Rps6 Rps6 PDPK1 PDPK1 PRKCB PRKCB COL1A1 COL1A1 VTN VTN MAP2K1 MAP2K1 FRS2 FRS2 SOS1 SOS1 PTCH1 PTCH1 TNF TNF PLCG2 PLCG2 HPSE HPSE GPC3 GPC3 TGFB1 TGFB1 RAF1 RAF1 PTK2 PTK2 PLAU PLAU PIK3CB PIK3CB VAV3 VAV3 GPC1 GPC1 HGF HGF WNT8A WNT8A PXN PXN WNT2B WNT2B PAK1 PAK1 EGFR EGFR PIK3CA PIK3CA CAMK2A CAMK2A HPSE2 HPSE2 DDX5 DDX5 MMP9 MMP9 TGFB2 TGFB2 ITGA5 ITGA5 CD44 CD44 PIK3R1 PIK3R1 CCDC170 CCDC170 ESR1 ESR1 SDC1 SDC1 H0VDD3_CAVPO H0VDD3_CAVPO CD63 CD63 ELK1 ELK1 WNT11 WNT11 CTSV CTSV WNT3 WNT3 WNT9B WNT9B ITGB5 ITGB5 PLCE1 PLCE1 FZD3 FZD3 KDR KDR HBEGF HBEGF ROCK1 ROCK1 ARHGEF12 ARHGEF12 FLNB FLNB COL1A2 COL1A2 NRAS NRAS KRAS KRAS PLAUR PLAUR ERBB4 ERBB4 Itgb3 Itgb3 HOXD10 HOXD10 MTOR MTOR LPXN LPXN GAB1 GAB1 FZD6 FZD6 ITPR2 ITPR2 Casp3 Casp3 ROCK2 ROCK2 FN1 FN1 PIK3CD PIK3CD MAPK1 MAPK1 ARAF ARAF SMO SMO SMAD2 SMAD2 MET MET PTPN11 PTPN11 TIAM1 TIAM1 IQGAP1 IQGAP1 FZD4 FZD4 RHOC RHOC MAPK13 MAPK13 WNT7B WNT7B RPS6KB1 RPS6KB1 THBS1 THBS1 ERBB3 ERBB3 MAPK12 MAPK12 PRKCA PRKCA DROSHA DROSHA TLR4 TLR4 ITGAV ITGAV AKT3 AKT3 ITGA2 ITGA2 MAP2K2 MAP2K2 ACTRT2 ACTRT2 WNT1 WNT1 PLCG1 PLCG1 FZD7 FZD7 H0W027_CAVPO H0W027_CAVPO CAMK2B CAMK2B ACTL7B ACTL7B ACTRT1 ACTRT1 Ankrd60 Ankrd60 FZD1 FZD1 LOC100731872 LOC100731872 HSPG2 HSPG2 ARSI ARSI H0W774_CAVPO H0W774_CAVPO IQANK1 IQANK1 H0W7V4_CAVPO H0W7V4_CAVPO WNT8B WNT8B ACTL9 ACTL9 ACTL8 ACTL8 ITPR3 ITPR3 TLR2 TLR2 PPP1R12C PPP1R12C TWIST2 TWIST2 MMP2 MMP2 H0WDS6_CAVPO H0WDS6_CAVPO MDM2 MDM2 RRAS2 RRAS2 SOS2 SOS2 ACTB ACTB ENSCPOP00000022264 ENSCPOP00000022264 RDX RDX RAC1 RAC1 MAPK14 MAPK14 CAMK2G CAMK2G C11orf1 C11orf1 ZSCAN2 ZSCAN2 PPP1CA PPP1CA WNT5A WNT5A VAV2 VAV2 PPP1CB PPP1CB RPS6KB2 RPS6KB2 TIMP3 TIMP3 WNT2 WNT2 MAPK11 MAPK11 MAPK3 MAPK3 PRKCG PRKCG WNT3A WNT3A MYC MYC STAT3 STAT3 CDKN1A CDKN1A PDCD4 PDCD4 WNT10A WNT10A MRAS MRAS AKT1 AKT1 WNT9A WNT9A ANK2 ANK2 FZD9 FZD9 PRKACB PRKACB Vegfa Vegfa CCND1 CCND1 Cav2 Cav2 SDC4 SDC4 PTPN6 PTPN6 FLNA FLNA CAV1 CAV1 WNT6 WNT6 IGF2 IGF2 SLC9A1 SLC9A1 WNT16 WNT16 ENSCPOP00000028322 ENSCPOP00000028322 RRAS RRAS WNT10B WNT10B FLNC FLNC Hspb2 Hspb2 CBL CBL LUM LUM ANK1 ANK1 TP53 TP53 FZD2 FZD2 Ank3 Ank3 FZD5 FZD5 FZD10 FZD10 LOC100734206 LOC100734206 Eif4b Eif4b ITPR1 ITPR1 Camk2d Camk2d ACTG1 ACTG1 CAV3 CAV3 IHH IHH PPP1R12B PPP1R12B FAS FAS SHH SHH RHOA RHOA MSN MSN Arhgef1 Arhgef1 Faslg Faslg AKT2 AKT2 CDC42 CDC42 GRB2 GRB2 BRAF BRAF WNT5B WNT5B ITGB1 ITGB1 NUDT16L1 NUDT16L1 CSDE1 CSDE1 IGF1 IGF1 SDC2 SDC2 DCN DCN WNT4 WNT4 CTNNB1 CTNNB1 HRAS HRAS Prkaca Prkaca EZR EZR WNT7A WNT7A ENSCPOP00000033096 ENSCPOP00000033096
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGFR1Fibroblast growth factor receptor. (822 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (472 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CTTNCortactin. (550 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
TFAP4Transcription factor AP-4. (339 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1069 aa)
Rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
COL1A1Collagen type I alpha 1 chain. (1454 aa)
VTNSMB domain-containing protein. (482 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PTCH1Patched 1. (1379 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
HPSEHeparanase. (526 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (529 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
PLAUPlasminogen activator, urokinase. (434 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
VAV3Vav guanine nucleotide exchange factor 3. (779 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
HPSE2Heparanase 2 (inactive). (543 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1102 aa)
CD44CD44 molecule (Indian blood group). (660 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CCDC170Coiled-coil domain containing 170. (688 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (327 aa)
H0VDD3_CAVPOHomeobox domain-containing protein. (286 aa)
CD63Tetraspanin. (238 aa)
ELK1ETS transcription factor ELK1. (422 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1496 aa)
FLNBFilamin B. (2602 aa)
COL1A2Collagen type I alpha 2 chain. (1287 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLAURPlasminogen activator, urokinase receptor. (309 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
HOXD10Homeobox D10. (340 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
LPXNLeupaxin. (381 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
Casp3CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
FN1Fibronectin 1. (2478 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (608 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1590 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1603 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
RHOCRas homolog family member C. (193 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
THBS1Thrombospondin 1. (1163 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
DROSHADrosha ribonuclease III. (1295 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (376 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
ACTL7BActin like 7B; Belongs to the actin family. (412 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
Ankrd60ANK_REP_REGION domain-containing protein. (195 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
LOC100731872Uncharacterized protein; Belongs to the actin family. (1226 aa)
HSPG2Heparan sulfate proteoglycan 2. (4264 aa)
ARSIArylsulfatase family member I. (572 aa)
H0W774_CAVPO40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (227 aa)
IQANK1IQ motif and ankyrin repeat containing 1. (568 aa)
H0W7V4_CAVPO40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
ACTL9Actin like 9; Belongs to the actin family. (388 aa)
ACTL8Actin like 8; Belongs to the actin family. (371 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (758 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
H0WDS6_CAVPOUncharacterized protein. (533 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RRAS2RAS related 2. (168 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ENSCPOP00000022264Uncharacterized protein. (566 aa)
RDXRadixin. (604 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
C11orf1Chromosome 11 open reading frame 1. (120 aa)
ZSCAN2Zinc finger and SCAN domain containing 2. (601 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
VAV2Vav guanine nucleotide exchange factor 2. (807 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (169 aa)
PDCD4Programmed cell death 4. (469 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
ANK2Ankyrin 2. (3876 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (125 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FLNAFilamin A. (2645 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ENSCPOP00000028322RRM domain-containing protein. (576 aa)
RRASRAS related. (218 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
FLNCFilamin C. (2726 aa)
Hspb2SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (183 aa)
CBLCbl proto-oncogene. (894 aa)
LUMLumican. (340 aa)
ANK1Ankyrin 1. (1911 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
Ank3Uncharacterized protein. (1948 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (505 aa)
LOC100734206Uncharacterized protein. (461 aa)
Eif4bRRM domain-containing protein. (611 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ACTG1Actin gamma 1. (375 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (1053 aa)
FASFas cell surface death receptor. (334 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
RHOARas homolog family member A. (193 aa)
MSNMoesin. (577 aa)
Arhgef1RGS-like domain-containing protein. (102 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CDC42Cell division cycle 42. (191 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
NUDT16L1Nudix hydrolase 16 like 1. (211 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
CTNNB1Catenin beta 1. (781 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
EZREzrin. (586 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSCPOP00000033096DH domain-containing protein. (302 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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