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| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (214 aa) |
| | Notch4 | Uncharacterized protein. (1988 aa) |
| | SIRT1 | Sirtuin 1. (717 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa) |
| | PLAU | Plasminogen activator, urokinase. (434 aa) |
| | VIM | IF rod domain-containing protein; Belongs to the intermediate filament family. (445 aa) |
| | ADAM15 | ADAM metallopeptidase domain 15. (862 aa) |
| | EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (230 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | APC | APC regulator of WNT signaling pathway. (2842 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa) |
| | GLS2 | Glutaminase 2. (558 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa) |
| | MMP16 | Matrix metallopeptidase 16. (565 aa) |
| | RASSF1 | Ras association domain family member 1. (340 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1253 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa) |
| | TRIM71 | Tripartite motif containing 71. (866 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1531 aa) |
| | H0V4H8_CAVPO | KH domain-containing protein. (145 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa) |
| | IRS1 | Insulin receptor substrate 1. (1243 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (629 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1256 aa) |
| | ABL1 | Tyrosine-protein kinase. (1145 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa) |
| | CEP152 | Centrosomal protein 152. (1666 aa) |
| | Shc4 | Uncharacterized protein. (372 aa) |
| | PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa) |
| | CDCA5 | Cell division cycle associated 5. (248 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (281 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (967 aa) |
| | FSCN2 | Fascin. (492 aa) |
| | CDC25B | Cell division cycle 25B. (579 aa) |
| | MMP9 | Matrix metallopeptidase 9. (715 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1126 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1102 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (967 aa) |
| | CD44 | CD44 molecule (Indian blood group). (660 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | FSCN1 | Fascin. (493 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (485 aa) |
| | E2F2 | E2F transcription factor 2. (431 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (501 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (739 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | Itgb3 | Integrin beta; Belongs to the integrin beta chain family. (735 aa) |
| | HOXD10 | Homeobox D10. (340 aa) |
| | ST14 | Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (830 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | TNN | Tenascin N. (1473 aa) |
| | Casp3 | CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (165 aa) |
| | GLS | Glutaminase. (649 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa) |
| | NOTCH1 | Notch receptor 1. (2472 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (325 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa) |
| | H0VN16_CAVPO | Uncharacterized protein. (71 aa) |
| | Ccne2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | MET | MET proto-oncogene, receptor tyrosine kinase. (1380 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | Serpinb5 | SERPIN domain-containing protein; Belongs to the serpin family. (375 aa) |
| | ZFPM2 | Zinc finger protein, FOG family member 2. (1079 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | RHOC | Ras homolog family member C. (193 aa) |
| | THBS1 | Thrombospondin 1. (1163 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1336 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (835 aa) |
| | NOTCH2 | Notch receptor 2. (2455 aa) |
| | MAP2K2 | Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (547 aa) |
| | PIM1 | Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa) |
| | TNC | Tenascin C. (2203 aa) |
| | NOTCH3 | Notch receptor 3. (2141 aa) |
| | H0W027_CAVPO | Uncharacterized protein. (722 aa) |
| | CDKN2A | Cyclin dependent kinase inhibitor 2A. (134 aa) |
| | BCL2 | BCL2 apoptosis regulator. (183 aa) |
| | Ccnd2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa) |
| | LOC100721187 | Uncharacterized protein. (489 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (521 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (903 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (190 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (481 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa) |
| | H0W664_CAVPO | Uncharacterized protein. (1232 aa) |
| | SHC1 | SHC adaptor protein 1. (583 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (592 aa) |
| | Sox4 | HMG box domain-containing protein. (227 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1600 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (217 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2086 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa) |
| | HMOX1 | Heme oxygenase 1. (297 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa) |
| | SOX12 | Transcription factor SOX. (310 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | ENSCPOP00000021738 | RING-type domain-containing protein. (326 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1327 aa) |
| | LOC100732684 | Uncharacterized protein. (1219 aa) |
| | ENSCPOP00000022082 | SERPIN domain-containing protein; Belongs to the serpin family. (327 aa) |
| | RDX | Radixin. (604 aa) |
| | Foxp1 | Fork-head domain-containing protein. (687 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (169 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (801 aa) |
| | CDC25A | Cell division cycle 25A. (519 aa) |
| | E2F1 | E2F transcription factor 1. (389 aa) |
| | Vegfa | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | E2F3 | E2F transcription factor 3. (457 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (228 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | LOC100726317 | Uncharacterized protein. (421 aa) |
| | BCL2L2 | BCL2 like 2. (193 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (540 aa) |
| | EFNA1 | Ephrin A1; Belongs to the ephrin family. (166 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) |
| | LOC100734206 | Uncharacterized protein. (461 aa) |
| | BMF | Bcl2 modifying factor. (236 aa) |
| | Tnxb | Uncharacterized protein. (3465 aa) |
| | BCL2L11 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa) |
| | ENSCPOP00000030705 | CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | EFNA4 | Ephrin A4; Belongs to the ephrin family. (204 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (316 aa) |
| | MCL1 | MCL1 apoptosis regulator, BCL2 family member. (233 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | CREBBP | CREB binding protein. (2441 aa) |
| | CSDE1 | Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | EZR | Ezrin. (586 aa) |
