STRINGSTRING
PARP8 PARP8 EGFR EGFR SLC2A1 SLC2A1 PIK3CB PIK3CB RAF1 RAF1 PFKP PFKP PARP6 PARP6 GLS2 GLS2 MAP2K1 MAP2K1 NTRK1 NTRK1 SLC1A5 SLC1A5 HIF1A HIF1A ERBB2 ERBB2 PDGFRB PDGFRB HK1 HK1 FGFR1 FGFR1 PIK3CA PIK3CA SLC7A5 SLC7A5 PGAM2 PGAM2 PDHB PDHB LOC100728682 LOC100728682 FLT3 FLT3 PIK3R1 PIK3R1 PFKM PFKM IDH2 IDH2 PKM PKM HK2 HK2 Pdha1 Pdha1 TIGAR TIGAR HK3 HK3 NRAS NRAS KRAS KRAS KIT KIT MTOR MTOR PDGFRA PDGFRA LDHC LDHC SLC2A2 SLC2A2 RET RET AKT3 AKT3 MAP2K2 MAP2K2 SLC16A3 SLC16A3 SCO2 SCO2 H0VZA0_CAVPO H0VZA0_CAVPO H0W027_CAVPO H0W027_CAVPO LOC100721187 LOC100721187 H0W5C1_CAVPO H0W5C1_CAVPO PTEN PTEN G6PD G6PD SIRT3 SIRT3 PFKL PFKL H0WDE6_CAVPO H0WDE6_CAVPO PDK1 PDK1 MAPK3 MAPK3 NTRK3 NTRK3 LDHA LDHA MYC MYC AKT1 AKT1 IDH1 IDH1 FGFR3 FGFR3 HKDC1 HKDC1 FGFR2 FGFR2 Ldhb Ldhb PGAM1 PGAM1 GCK GCK TP53 TP53 LOC100734206 LOC100734206 AKT2 AKT2 CSDE1 CSDE1 HRAS HRAS MET MET MAPK1 MAPK1 PIK3CD PIK3CD GLS GLS TNIK TNIK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARP8Poly [ADP-ribose] polymerase. (879 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (792 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
GLS2Glutaminase 2. (558 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
SLC1A5Amino acid transporter. (471 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
HK1Hexokinase 1. (919 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
SLC7A5Solute carrier family 7 member 5. (477 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
LOC100728682Uncharacterized protein. (301 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
HK2Hexokinase 2. (917 aa)
Pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
HK3Hexokinase 3. (864 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1114 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SLC16A3Solute carrier family 16 member 3. (465 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (252 aa)
H0VZA0_CAVPOUncharacterized protein. (229 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
LOC100721187Uncharacterized protein. (489 aa)
H0W5C1_CAVPOPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (751 aa)
H0WDE6_CAVPOUncharacterized protein. (251 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
FGFR3Fibroblast growth factor receptor. (801 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
LdhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
GCKPhosphotransferase. (414 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
LOC100734206Uncharacterized protein. (461 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
GLSGlutaminase. (649 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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