STRINGSTRING
Txn Txn MAPK12 MAPK12 MAPK13 MAPK13 RHOC RHOC MAP2K4 MAP2K4 CALML3 CALML3 RAC3 RAC3 CCL2 CCL2 PIK3CD PIK3CD GSTO2 GSTO2 NQO1 NQO1 SELE SELE PECAM1 PECAM1 H0VKV0_CAVPO H0VKV0_CAVPO H0VJY6_CAVPO H0VJY6_CAVPO Itgb3 Itgb3 IFNG IFNG IKBKB IKBKB KDR KDR PRKAA2 PRKAA2 CTSV CTSV NCF2 NCF2 SDC1 SDC1 NCF1 NCF1 GPC1 GPC1 PIK3CB PIK3CB PTK2 PTK2 GSTO1 GSTO1 CALM2 CALM2 IL1B IL1B Hsp90aa1 Hsp90aa1 TNF TNF PIAS4 PIAS4 CALM1 CALM1 HSP90AB1 HSP90AB1 NOS3 NOS3 PDGFB PDGFB PRKAA1 PRKAA1 ACTL7A ACTL7A PIK3CA PIK3CA VCAM1 VCAM1 ITGA2B ITGA2B BMP4 BMP4 MMP9 MMP9 NFKB1 NFKB1 GSTM1 GSTM1 PIK3R1 PIK3R1 ACVR2A ACVR2A ACVR1 ACVR1 MAPK10 MAPK10 KEAP1 KEAP1 CTNNB1 CTNNB1 TXN2 TXN2 IL1R2 IL1R2 PDGFA PDGFA ENSCPOP00000032444 ENSCPOP00000032444 SDC2 SDC2 ENSCPOP00000032059 ENSCPOP00000032059 CHUK CHUK MGST1 MGST1 SUMO4 SUMO4 MEF2A MEF2A AKT2 AKT2 RHOA RHOA CDH5 CDH5 GSTA4 GSTA4 CAV3 CAV3 ACTG1 ACTG1 IL1R1 IL1R1 LOC100734206 LOC100734206 TP53 TP53 Gstm2 Gstm2 BMPR2 BMPR2 TNFRSF1A TNFRSF1A EDN1 EDN1 MAP2K5 MAP2K5 MAP3K5 MAP3K5 NFE2L2 NFE2L2 HSP90B1 HSP90B1 SUMO1 SUMO1 CALM3 CALM3 CAV1 CAV1 TRPV4 TRPV4 LOC100717598 LOC100717598 SDC4 SDC4 Cav2 Cav2 LOC106027640 LOC106027640 ACVR2B ACVR2B DUSP1 DUSP1 Vegfa Vegfa LOC100717552 LOC100717552 LOC100715394 LOC100715394 Sumo2 Sumo2 AKT1 AKT1 MAP3K7 MAP3K7 MAPK9 MAPK9 ENSCPOP00000024881 ENSCPOP00000024881 LOC100717315 LOC100717315 MAPK8 MAPK8 MAPK11 MAPK11 NOX1 NOX1 GSTM3 GSTM3 CALML4 CALML4 SQSTM1 SQSTM1 BMPR1B BMPR1B LOC100725824 LOC100725824 ARHGEF2 ARHGEF2 MAPK14 MAPK14 RAC1 RAC1 MAP2K6 MAP2K6 MEF2C MEF2C ACTB ACTB LOC100717041 LOC100717041 FOS FOS GSTA1_CAVPO GSTA1_CAVPO JUN JUN MGST2 MGST2 ASS1 ASS1 GSTT4 GSTT4 H0WCB2_CAVPO H0WCB2_CAVPO MMP2 MMP2 IKBKG IKBKG HMOX1 HMOX1 MAPK7 MAPK7 GSTP1 GSTP1 THBD THBD ACTL8 ACTL8 ACTL9 ACTL9 BMPR1A BMPR1A LOC100731872 LOC100731872 NPPC NPPC ACTRT1 ACTRT1 ACTL7B ACTL7B BCL2 BCL2 IL1A IL1A H0W1R6_CAVPO H0W1R6_CAVPO PLAT PLAT H0W027_CAVPO H0W027_CAVPO RELA RELA MAP2K7 MAP2K7 CYBA CYBA SUMO3 SUMO3 ACTRT2 ACTRT2 RAC2 RAC2 AKT3 AKT3 ITGAV ITGAV MGST3 MGST3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TxnThioredoxin; Belongs to the thioredoxin family. (105 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RHOCRas homolog family member C. (193 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
RAC3Rac family small GTPase 3. (192 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (120 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis; Belongs to the NAD(P)H dehydrogenase (quinone) family. (275 aa)
SELESelectin E. (586 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (743 aa)
H0VKV0_CAVPOUncharacterized protein; Belongs to the calmodulin family. (139 aa)
H0VJY6_CAVPOThioredoxin domain-containing protein. (135 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
NCF2Neutrophil cytosolic factor 2. (513 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (327 aa)
NCF1Neutrophil cytosolic factor 1. (401 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (239 aa)
CALM2Calmodulin isoform 3; Belongs to the calmodulin family. (149 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
PIAS4Protein inhibitor of activated STAT 4. (514 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (194 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1007 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
GSTM1Glutathione S-transferase B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (222 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
KEAP1Kelch like ECH associated protein 1. (411 aa)
CTNNB1Catenin beta 1. (781 aa)
TXN2Thioredoxin 2. (160 aa)
IL1R2Interleukin 1 receptor type 2. (440 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
ENSCPOP00000032444annotation not available (74 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
ENSCPOP00000032059Uncharacterized protein; Belongs to the calmodulin family. (73 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
MGST1Microsomal glutathione S-transferase 1. (156 aa)
SUMO4Small ubiquitin-related modifier. (81 aa)
MEF2AMyocyte enhancer factor 2A. (517 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RHOARas homolog family member A. (193 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (747 aa)
GSTA4Glutathione S-transferase alpha 4. (252 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ACTG1Actin gamma 1. (375 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
LOC100734206Uncharacterized protein. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
Gstm2Glutathione S-transferase. (218 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1344 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (591 aa)
HSP90B1Heat shock protein 90 beta family member 1. (807 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
CALM3Calmodulin 3. (149 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
LOC100717598Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (125 aa)
LOC106027640C-C motif chemokine. (97 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (368 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
LOC100717552C-C motif chemokine. (120 aa)
LOC100715394Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
Sumo2Small ubiquitin-related modifier. (95 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSCPOP00000024881Rad60-SLD domain-containing protein. (74 aa)
LOC100717315Uncharacterized protein. (240 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
NOX1NADPH oxidase 1. (564 aa)
GSTM3Glutathione S-transferase mu 3; Belongs to the GST superfamily. (225 aa)
CALML4Calmodulin like 4. (153 aa)
SQSTM1Sequestosome 1. (415 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
LOC100717041Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GSTA1_CAVPOGlutathione S-transferase A; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
ASS1Argininosuccinate synthase 1. (415 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
H0WCB2_CAVPOUncharacterized protein. (418 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
HMOX1Heme oxygenase 1. (297 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
THBDThrombomodulin. (534 aa)
ACTL8Actin like 8; Belongs to the actin family. (371 aa)
ACTL9Actin like 9; Belongs to the actin family. (388 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
LOC100731872Uncharacterized protein; Belongs to the actin family. (1226 aa)
NPPCNatriuretic peptide C. (126 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
ACTL7BActin like 7B; Belongs to the actin family. (412 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (272 aa)
H0W1R6_CAVPOThioredoxin; Belongs to the thioredoxin family. (106 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (559 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (459 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (189 aa)
SUMO3Small ubiquitin-related modifier. (109 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (376 aa)
RAC2Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). (192 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
MGST3Microsomal glutathione S-transferase 3. (156 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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