(35 nodes) RNA Polymerase II Transcription Elongation network (Heterocephalus glaber)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Polr2d	DNA-directed RNA polymerase II subunit RPB4. (142 aa)
	Sidt1	SID1 transmembrane family member 1. (832 aa)
	GW7_00758	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (55 aa)
	Ctdp1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (963 aa)
	Cdc73	Parafibromin. (533 aa)
	POLR2C	DNA-directed RNA polymerase II subunit RPB3. (275 aa)
	Upk3bl	Uroplakin-3-like protein. (172 aa)
	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
	POLR2F	DNA-directed RNA polymerases I, II, and III subunit RPABC2. (127 aa)
	Rpap2	RNA polymerase II-associated protein 2. (572 aa)
	GW7_02037	Transcription elongation factor A protein 3. (343 aa)
	POLR2A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1970 aa)
	Tcea1	Transcription elongation factor A protein 1. (285 aa)
	Iws1	IWS1-like protein. (844 aa)
	CTR9	RNA polymerase-associated protein CTR9-like protein. (1179 aa)
	SUPT16H	FACT complex subunit SPT16. (1047 aa)
	GW7_07499	Transcription elongation factor A protein 3. (543 aa)
	Supt5h	Transcription elongation factor SPT5. (1094 aa)
	PAF1	RNA polymerase II-associated factor 1 homolog isoform 2. (535 aa)
	SUPT4H1	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
	POLR2I	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
	Ssrp1	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
	Rtf1	RNA polymerase-associated protein RTF1-like protein. (704 aa)
	GW7_13057	S-antigen protein. (302 aa)
	GW7_13466	Parafibromin. (451 aa)
	Supt6h	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1738 aa)
	GW7_13998	Uncharacterized protein. (505 aa)
	GW7_01683	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (677 aa)
	GW7_04760	Uncharacterized protein. (285 aa)
	GW7_06258	DNA-directed RNA polymerase II subunit RPB2. (221 aa)
	GW7_15276	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (513 aa)
	GW7_16238	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (278 aa)
	GW7_09708	Transcription elongation factor A protein 2. (335 aa)
	Polr2l	DNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
	Leo1	RNA polymerase-associated protein LEO1. (665 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTR9	Cdc73	G5BFG7	G5ASG2	RNA polymerase-associated protein CTR9-like protein.	Parafibromin.	0.980
CTR9	GW7_00758	G5BFG7	G5ANZ3	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC4.	0.871
CTR9	GW7_01683	G5BFG7	G5C2X8	RNA polymerase-associated protein CTR9-like protein.	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.938
CTR9	GW7_02037	G5BFG7	G5B2P1	RNA polymerase-associated protein CTR9-like protein.	Transcription elongation factor A protein 3.	0.594
CTR9	GW7_04760	G5BFG7	G5C3D0	RNA polymerase-associated protein CTR9-like protein.	Uncharacterized protein.	0.913
CTR9	GW7_06258	G5BFG7	G5C3M7	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerase II subunit RPB2.	0.935
CTR9	GW7_07499	G5BFG7	G5BHY9	RNA polymerase-associated protein CTR9-like protein.	Transcription elongation factor A protein 3.	0.594
CTR9	GW7_09708	G5BFG7	G5C8A8	RNA polymerase-associated protein CTR9-like protein.	Transcription elongation factor A protein 2.	0.594
CTR9	GW7_13057	G5BFG7	G5BN66	RNA polymerase-associated protein CTR9-like protein.	S-antigen protein.	0.632
CTR9	GW7_13466	G5BFG7	G5BSH5	RNA polymerase-associated protein CTR9-like protein.	Parafibromin.	0.980
CTR9	GW7_13998	G5BFG7	G5BZG5	RNA polymerase-associated protein CTR9-like protein.	Uncharacterized protein.	0.632
CTR9	GW7_16238	G5BFG7	G5C5N8	RNA polymerase-associated protein CTR9-like protein.	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]	0.938
CTR9	Iws1	G5BFG7	G5B9V4	RNA polymerase-associated protein CTR9-like protein.	IWS1-like protein.	0.909
CTR9	Leo1	G5BFG7	G5C9D5	RNA polymerase-associated protein CTR9-like protein.	RNA polymerase-associated protein LEO1.	0.999
CTR9	PAF1	G5BFG7	G5BJE1	RNA polymerase-associated protein CTR9-like protein.	RNA polymerase II-associated factor 1 homolog isoform 2.	0.999
CTR9	POLR2A	G5BFG7	G5B5C5	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.979
CTR9	POLR2C	G5BFG7	G5AUE7	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerase II subunit RPB3.	0.944
CTR9	POLR2F	G5BFG7	G5AYS1	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC2.	0.879
CTR9	POLR2I	G5BFG7	G5BK10	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.852
CTR9	POLR2J	G5BFG7	G5AXA4	RNA polymerase-associated protein CTR9-like protein.	DNA-directed RNA polymerase II subunit RPB11-a.	0.885