(54 nodes) Intrinsic Pathway for Apoptosis, and Inflammasome complex network (Heterocephalus glaber)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Pstpip1	Proline-serine-threonine phosphatase-interacting protein 1. (419 aa)
	GW7_08063	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (103 aa)
	GW7_15220	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (286 aa)
	GW7_15223	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (80 aa)
	Bcl2l2	Bcl-2-like protein 2. (193 aa)
	IRF1	Interferon regulatory factor. (326 aa)
	Bbc3	Bcl-2-binding component 3. (158 aa)
	CSTA	Cystatin-A; Belongs to the cystatin family. (99 aa)
	GW7_21492	Gasdermin-D. (483 aa)
	GW7_03122	Diablo-like protein, mitochondrial. (252 aa)
	Parp3	Poly [ADP-ribose] polymerase. (531 aa)
	GW7_11035	Caspase-3; Belongs to the peptidase C14A family. (206 aa)
	Mefv	Pyrin. (810 aa)
	Cideb	Cell death activator CIDE-B. (230 aa)
	Birc6	Baculoviral IAP repeat-containing protein 6. (4851 aa)
	GW7_02624	NLR family CARD domain-containing protein 4. (947 aa)
	GW7_01665	Tyrosine-protein phosphatase non-receptor type 12. (170 aa)
	Capn1	Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (728 aa)
	GW7_20676	Bcl2 antagonist of cell death. (105 aa)
	BAX	Apoptosis regulator BAX isoform alpha. (192 aa)
	Parp1	Poly [ADP-ribose] polymerase. (1132 aa)
	GW7_15779	Transmembrane protein 198. (350 aa)
	GW7_15022	Apoptotic protease-activating factor 1. (1074 aa)
	Dfna5	Non-syndromic hearing impairment protein 5. (498 aa)
	Bcl2a1	Bcl-2-related protein A1. (174 aa)
	CASP3	Caspase-3 preproprotein; Belongs to the peptidase C14A family. (277 aa)
	Aven	Cell death regulator Aven. (219 aa)
	Bcl2	Apoptosis regulator Bcl-2. (239 aa)
	BAK1	Putative Bcl-2-like protein antagonist/killer 2. (212 aa)
	Casp7	Caspase-7; Belongs to the peptidase C14A family. (303 aa)
	Bik	Bcl-2-interacting killer. (186 aa)
	BCL2L1	Bcl-2-like protein 1 isoform 2. (233 aa)
	Bcl2l11	Bcl-2-like protein 11. (200 aa)
	GW7_20578	Induced myeloid leukemia cell differentiation protein Mcl-1-like protein. (195 aa)
	Gzmb	Granzyme B; Belongs to the peptidase S1 family. (253 aa)
	Casp9	Caspase-9; Belongs to the peptidase C14A family. (415 aa)
	Birc2	Baculoviral IAP repeat-containing protein 2. (618 aa)
	Casp1	Caspase-1; Belongs to the peptidase C14A family. (397 aa)
	Casp4	Caspase-4; Belongs to the peptidase C14A family. (306 aa)
	GW7_16663	Caspase-12; Belongs to the peptidase C14A family. (282 aa)
	GW7_04593	NACHT, LRR and PYD domains-containing protein 1. (1328 aa)
	Bid	BH3-interacting domain death agonist. (310 aa)
	GW7_14915	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
	GW7_18783	Caspase-3; Belongs to the peptidase C14A family. (150 aa)
	GW7_02274	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (87 aa)
	Naip	Baculoviral IAP repeat-containing protein 1. (1385 aa)
	GW7_14761	Caspase-3; Belongs to the peptidase C14A family. (277 aa)
	Bok	Bcl-2-related ovarian killer protein. (162 aa)
	PANX-2	Pannexin; Structural component of the gap junctions and the hemichannels. (391 aa)
	Nlrp6	NACHT, LRR and PYD domains-containing protein 6. (510 aa)
	GW7_13743	Baculoviral IAP repeat-containing protein 4. (183 aa)
	Dffa	DNAation factor subunit alpha. (331 aa)
	Huwe1	E3 ubiquitin-protein ligase HUWE1. (4388 aa)
	GW7_14661	DNAation factor subunit beta. (383 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aven	BCL2L1	G5BGS4	G5BQH7	Cell death regulator Aven.	Bcl-2-like protein 1 isoform 2.	0.641
Aven	Bcl2l2	G5BGS4	G5ASL3	Cell death regulator Aven.	Bcl-2-like protein 2.	0.403
Aven	CSTA	G5BGS4	G5AV85	Cell death regulator Aven.	Cystatin-A; Belongs to the cystatin family.	0.549
Aven	Casp9	G5BGS4	G5BRS8	Cell death regulator Aven.	Caspase-9; Belongs to the peptidase C14A family.	0.549
Aven	GW7_15022	G5BGS4	G5BBH4	Cell death regulator Aven.	Apoptotic protease-activating factor 1.	0.976
BAK1	BAX	G5BK25	G5BAG6	Putative Bcl-2-like protein antagonist/killer 2.	Apoptosis regulator BAX isoform alpha.	0.973
BAK1	BCL2L1	G5BK25	G5BQH7	Putative Bcl-2-like protein antagonist/killer 2.	Bcl-2-like protein 1 isoform 2.	0.997
BAK1	Bbc3	G5BK25	G5AV07	Putative Bcl-2-like protein antagonist/killer 2.	Bcl-2-binding component 3.	0.712
BAK1	Bcl2	G5BK25	G5BGZ7	Putative Bcl-2-like protein antagonist/killer 2.	Apoptosis regulator Bcl-2.	0.985
BAK1	Bcl2a1	G5BK25	G5BEY0	Putative Bcl-2-like protein antagonist/killer 2.	Bcl-2-related protein A1.	0.894
BAK1	Bcl2l11	G5BK25	G5BQZ0	Putative Bcl-2-like protein antagonist/killer 2.	Bcl-2-like protein 11.	0.943
BAK1	Bcl2l2	G5BK25	G5ASL3	Putative Bcl-2-like protein antagonist/killer 2.	Bcl-2-like protein 2.	0.918
BAK1	Bid	G5BK25	G5BWN8	Putative Bcl-2-like protein antagonist/killer 2.	BH3-interacting domain death agonist.	0.997
BAK1	Capn1	G5BK25	G5B6L3	Putative Bcl-2-like protein antagonist/killer 2.	Calpain-1 catalytic subunit; Belongs to the peptidase C2 family.	0.913
BAK1	Casp9	G5BK25	G5BRS8	Putative Bcl-2-like protein antagonist/killer 2.	Caspase-9; Belongs to the peptidase C14A family.	0.815
BAK1	GW7_02274	G5BK25	G5BYF1	Putative Bcl-2-like protein antagonist/killer 2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.490
BAK1	GW7_03122	G5BK25	G5AWQ6	Putative Bcl-2-like protein antagonist/killer 2.	Diablo-like protein, mitochondrial.	0.710
BAK1	GW7_08063	G5BK25	G5ALW3	Putative Bcl-2-like protein antagonist/killer 2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.490
BAK1	GW7_14915	G5BK25	G5BX00	Putative Bcl-2-like protein antagonist/killer 2.	Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.946
BAK1	GW7_15022	G5BK25	G5BBH4	Putative Bcl-2-like protein antagonist/killer 2.	Apoptotic protease-activating factor 1.	0.639