(31 nodes) Mixed, incl. Eyes absent family, and Homeobox protein SIX1, N-terminal SD domain network (Heterocephalus glaber)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GW7_05701	Homeobox protein HMX3. (384 aa)
	Eya4	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (634 aa)
	Eya3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (561 aa)
	Six5	Homeobox protein SIX5. (606 aa)
	Crx	Cone-rod homeobox protein. (299 aa)
	Rax	Retinal homeobox protein Rx. (211 aa)
	Znf366	Zinc finger protein 366. (739 aa)
	Serpina3	Alpha-1-antichymotrypsin; Belongs to the serpin family. (426 aa)
	Hhex	Hematopoietically-expressed homeobox protein HHEX. (151 aa)
	Dach1	Dachshund-like protein 1. (214 aa)
	GW7_20968	Dachshund-like protein 1. (255 aa)
	Eya1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (532 aa)
	Argfx	Arginine-fifty homeobox. (208 aa)
	Cdh16	Cadherin-16. (829 aa)
	GW7_04263	Homeobox protein OTX2. (177 aa)
	GW7_12326	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (338 aa)
	Myf5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	Hinfp	Histone H4 transcription factor. (655 aa)
	ALX1	ALX homeobox protein 1. (327 aa)
	GW7_17565	Dachshund-like protein 2. (332 aa)
	GW7_06748	LIM homeobox transcription factor 1-beta. (395 aa)
	Slco2a1	Solute carrier organic anion transporter family member. (618 aa)
	Prrx1	Paired mesoderm homeobox protein 1. (167 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	GW7_21075	Homeobox protein SIX4. (759 aa)
	GW7_04834	Homeobox protein OTX2. (194 aa)
	GW7_14346	Wilms tumor protein. (517 aa)
	GW7_19370	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (288 aa)
	Six2	Homeobox protein SIX2. (295 aa)
	GW7_18590	Homeobox protein SIX3. (360 aa)
	GW7_15874	Paired box protein Pax-2. (702 aa)

Your Current Organism:

Heterocephalus glaber

NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Argfx	GW7_14346	G5BBK6	G5C8K4	Arginine-fifty homeobox.	Wilms tumor protein.	0.544
Argfx	GW7_18590	G5BBK6	G5C9U1	Arginine-fifty homeobox.	Homeobox protein SIX3.	0.564
Argfx	Myf5	G5BBK6	G5BH15	Arginine-fifty homeobox.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.451
Argfx	Serpina3	G5BBK6	G5B491	Arginine-fifty homeobox.	Alpha-1-antichymotrypsin; Belongs to the serpin family.	0.436
Argfx	Slco2a1	G5BBK6	G5BQA6	Arginine-fifty homeobox.	Solute carrier organic anion transporter family member.	0.511
Cdh16	Eya3	G5BDH5	G5AUV0	Cadherin-16.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.545
Cdh16	GW7_19370	G5BDH5	G5C9Q0	Cadherin-16.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.545
Crx	GW7_14346	G5AV21	G5C8K4	Cone-rod homeobox protein.	Wilms tumor protein.	0.544
Crx	GW7_18590	G5AV21	G5C9U1	Cone-rod homeobox protein.	Homeobox protein SIX3.	0.564
Crx	Myf5	G5AV21	G5BH15	Cone-rod homeobox protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.752
Crx	Slco2a1	G5AV21	G5BQA6	Cone-rod homeobox protein.	Solute carrier organic anion transporter family member.	0.427
Dach1	Eya1	G5B869	G5B8F9	Dachshund-like protein 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.544
Dach1	Eya3	G5B869	G5AUV0	Dachshund-like protein 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.419
Dach1	Eya4	G5B869	G5APK2	Dachshund-like protein 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.419
Dach1	GW7_12326	G5B869	G5BGU5	Dachshund-like protein 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.420
Dach1	GW7_17565	G5B869	G5BKN9	Dachshund-like protein 1.	Dachshund-like protein 2.	0.944
Dach1	GW7_19370	G5B869	G5C9Q0	Dachshund-like protein 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.419
Dach1	GW7_20968	G5B869	G5B870	Dachshund-like protein 1.	Dachshund-like protein 1.	0.898
Dach1	SIX1	G5B869	G5C5H8	Dachshund-like protein 1.	Homeobox protein SIX1.	0.464
Eya1	Dach1	G5B8F9	G5B869	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Dachshund-like protein 1.	0.544