STRINGSTRING
IL1B IL1B CALCA CALCA Selp Selp Sell Sell GW7_09533 GW7_09533 Cd47 Cd47 Podxl2 Podxl2 GW7_16114 GW7_16114 GW7_08094 GW7_08094 Cx3cr1 Cx3cr1 ITGB1 ITGB1 GW7_15578 GW7_15578 CHST4 CHST4 GW7_01443 GW7_01443 Lrg1 Lrg1 SEMA4D SEMA4D Itgal Itgal GW7_12270 GW7_12270 F11R F11R Pecam1 Pecam1 GW7_04498 GW7_04498 Golph3 Golph3 S100A9 S100A9 GW7_14169 GW7_14169 Ccr2 Ccr2 GW7_02449 GW7_02449 Ext1 Ext1 Bmp7 Bmp7 Msn Msn Selplg Selplg GW7_19302 GW7_19302 Vcam1 Vcam1 GW7_13188 GW7_13188 GW7_15413 GW7_15413 GW7_15414 GW7_15414 GW7_15415 GW7_15415 GW7_08248 GW7_08248 GW7_06323 GW7_06323 Ptprc Ptprc ADD2 ADD2 Fermt3 Fermt3 NT5E NT5E Rac2 Rac2 Stk10 Stk10 Tnip1 Tnip1 Ezr Ezr Olr1 Olr1 LEP LEP Itga5 Itga5 GW7_04438 GW7_04438 Itgb7 Itgb7 GW7_14235 GW7_14235 Gcnt1 Gcnt1 Thbs1 Thbs1 GW7_13901 GW7_13901 Cd24 Cd24 Apoa4 Apoa4 Jam2 Jam2 L1cam L1cam GW7_00892 GW7_00892
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (301 aa)
CALCACalcitonin gene-related peptide 1 alpha-CGRP preproprotein. (140 aa)
SelpP-selectin. (790 aa)
SellL-selectin. (360 aa)
GW7_09533E-selectin. (528 aa)
Cd47Leukocyte surface antigen CD47. (286 aa)
Podxl2Podocalyxin-like protein 2. (705 aa)
GW7_16114CUB and sushi domain-containing protein 3. (3000 aa)
GW7_08094Mucosal addressin cell adhesion molecule 1. (313 aa)
Cx3cr1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
GW7_15578Uromodulin. (671 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (383 aa)
GW7_01443Signal transducer CD24. (76 aa)
Lrg1Leucine-rich alpha-2-glycoprotein. (337 aa)
SEMA4DSemaphorin-4D isoform 2; Belongs to the semaphorin family. (862 aa)
ItgalIntegrin alpha-L; Belongs to the integrin alpha chain family. (1114 aa)
GW7_12270Junctional adhesion molecule A. (269 aa)
F11RJunctional adhesion molecule A. (299 aa)
Pecam1Platelet endothelial cell adhesion molecule. (740 aa)
GW7_04498Signal transducer CD24. (78 aa)
Golph3Golgi phosphoprotein 3. (206 aa)
S100A9Protein S100-A9; Belongs to the S-100 family. (118 aa)
GW7_14169Protein S100-A8. (90 aa)
Ccr2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
GW7_02449Leukocyte surface antigen CD47. (172 aa)
Ext1Exostosin-1; Belongs to the glycosyltransferase 47 family. (426 aa)
Bmp7Bone morphogenetic protein 7. (370 aa)
MsnMoesin. (615 aa)
SelplgP-selectin glycoprotein ligand 1. (405 aa)
GW7_19302Ezrin. (175 aa)
Vcam1Vascular cell adhesion protein 1. (742 aa)
GW7_13188Platelet endothelial cell adhesion molecule. (371 aa)
GW7_15413CD177 antigen. (135 aa)
GW7_15414CD177 antigen. (210 aa)
GW7_15415CD177 antigen. (195 aa)
GW7_08248Intercellular adhesion molecule 1. (523 aa)
GW7_06323Signal transducer CD24. (78 aa)
PtprcLeukocyte common antigen. (1313 aa)
ADD2Beta-adducin isoform a. (724 aa)
Fermt3Fermitin family-like protein 3. (673 aa)
NT5E5'-nucleotidase isoform 1 preproprotein; Belongs to the 5'-nucleotidase family. (574 aa)
Rac2Ras-related C3 botulinum toxin substrate 2. (192 aa)
Stk10Serine/threonine-protein kinase 10. (965 aa)
Tnip1TNFAIP3-interacting protein 1. (624 aa)
EzrEzrin. (606 aa)
Olr1Oxidized low-density lipoprotein receptor 1. (270 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
Itga5Integrin alpha-5; Belongs to the integrin alpha chain family. (1024 aa)
GW7_04438Protein S100-A8; Belongs to the S-100 family. (89 aa)
Itgb7Integrin beta; Belongs to the integrin beta chain family. (792 aa)
GW7_14235Integrin alpha-4; Belongs to the integrin alpha chain family. (908 aa)
Gcnt1Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (352 aa)
Thbs1Thrombospondin-1. (1914 aa)
GW7_13901Integrin beta. (1059 aa)
Cd24Signal transducer CD24. (78 aa)
Apoa4Apolipoprotein A-IV. (402 aa)
Jam2Junctional adhesion molecule B. (275 aa)
L1camNeural cell adhesion molecule L1. (1214 aa)
GW7_00892Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1353 aa)
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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