STRINGSTRING
Sirt2 Sirt2 Appl1 Appl1 GW7_00983 GW7_00983 Gclm Gclm VIL1 VIL1 GW7_02697 GW7_02697 GW7_03627 GW7_03627 LGMN LGMN Bcar1 Bcar1 Rela Rela IL6 IL6 Gclc Gclc GW7_20104 GW7_20104 GW7_06114 GW7_06114 IL10 IL10 Med1 Med1 Creb1 Creb1 GW7_19199 GW7_19199 Nrp1 Nrp1 GW7_14531 GW7_14531
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sirt2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
Appl1DCC-interacting protein 13-alpha. (699 aa)
GW7_00983Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (466 aa)
GclmGlutamate--cysteine ligase regulatory subunit. (233 aa)
VIL1Villin-1. (827 aa)
GW7_02697Hepatocyte growth factor; Belongs to the peptidase S1 family. (819 aa)
GW7_03627CREB-binding protein. (2098 aa)
LGMNLegumain preproprotein. (436 aa)
Bcar1Breast cancer anti-estrogen resistance protein 1. (932 aa)
RelaTranscription factor p65. (581 aa)
IL6Interleukin-6. (218 aa)
GclcGlutamate--cysteine ligase catalytic subunit. (466 aa)
GW7_20104Cyclic AMP-responsive element-binding protein 1. (129 aa)
GW7_06114Glutamate--cysteine ligase catalytic subunit. (146 aa)
IL10Interleukin-10. (178 aa)
Med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1564 aa)
Creb1Cyclic AMP-responsive element-binding protein 1. (341 aa)
GW7_19199DCC-interacting protein 13-beta. (741 aa)
Nrp1Neuropilin-1. (902 aa)
GW7_14531CREB-binding protein. (483 aa)
Your Current Organism:
Heterocephalus glaber
NCBI taxonomy Id: 10181
Other names: H. glaber, naked mole rat, naked mole-rat
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